Application of an improved wide-narrow-band hybrid ANC algorithm in a large commercial vehicle cabine.

In recent years, active noise reduction technology has become a research hotspot. However, most active noise reduction technologies are developed based on passenger vehicles and are not implemented in large commercial vehicles. The large commercial vehicle sound field space is large, the traditional active noise reduction method is difficult to implement. In order to explore this problem, this paper proposes an improved active noise control method for commercial vehicles: (1) based on the traditional notch filter, a notch FxLMS algorithm based on speed smoothing is proposed; (2) on the basis of the traditional wire-narrowband hybrid ANC algorithm, the reference signal weighting technology is introduced into the wide-band subsystem, and the notch FxLMS algorithm based on speed smoothing is used as the narrowband subsystem, so as to propose an improved wire-narrowband hybrid ANC algorithm. With the help of MATLAB, the simulation model of the designed algorithm is established, and the collected commercial vehicle test noise data is used as the reference signal to simulate and verify the proposed algorithm. The results show that the proposed method has certain practicability.

Research on modeling joining and joining modification method of hybrid FE-SEA model.

Since the connection method at the boundary of the hybrid FE-SEA (finite element-statistical energy analysis, FE-SEA) model affects the overall calculation accuracy of the model, the missing or inaccurate connection relation will lead to a large error in the model calculation. In order to effectively solve the calculation error caused by the connection problem of hybrid FE-SEA model, this paper starts from the modeling methods and connection relations of "hybrid-point" connection, "hybrid-line" connection and "hybrid-surface" connection. In order to solve the modeling method and correction problems of the "hybrid-point" connection in the hybrid FE-SEA model, the "out-of-plane" wave motion equation at the "hybrid-point" connection was established by using the superposition principle of plane waveforms in polar coordinate system. The "hybrid-point" connection and wave-number relation in Cartesian coordinate system are studied. The radiation radius correction method of "hybrid-point" connection is proposed. An example is given to verify the effectiveness of the method. In order to solve the modeling and correction problem of "hybrid-line" in hybrid model, a "hybrid-line" connected triangular waveform function model was established by using the method of linear difference. The direct field dynamic stiffness matrix of "hybrid-line" connection in node coordinate system is studied. According to the shape function of the "hybrid-line" connection wavenumber space, a method to correct the shape function of the "hybrid-line" connection is proposed, and the validity of the method is verified.

Microbial and human transcriptional profiling of coronavirus disease 2019 patients: Potential predictors of disease severity.

The high morbidity of patients with coronavirus disease 2019 (COVID-19) brings on a panic around the world. COVID-19 is associated with sex bias, immune system, and preexisting chronic diseases. We analyzed the gene expression in patients with COVID-19 and in their microbiota in order to identify potential biomarkers to aid in disease management. A total of 129 RNA samples from nasopharyngeal, oropharyngeal, and anal swabs were collected and sequenced in a high-throughput manner. Several microbial strains differed in abundance between patients with mild or severe COVID-19. Microbial genera were more abundant in oropharyngeal swabs than in nasopharyngeal or anal swabs. Oropharyngeal swabs allowed more sensitive detection of the causative SARS-CoV-2. Microbial and human transcriptomes in swabs from patients with mild disease showed enrichment of genes involved in amino acid metabolism, or protein modification via small protein removal, and antibacterial defense responses, respectively, whereas swabs from patients with severe disease showed enrichment of genes involved in drug metabolism, or negative regulation of apoptosis execution, spermatogenesis, and immune system, respectively. Microbial abundance and diversity did not differ significantly between males and females. The expression of several host genes on the X chromosome correlated negatively with disease severity. In this way, our analyses identify host genes whose differential expression could aid in the diagnosis of COVID-19 and prediction of its severity via non-invasive assay.