Chinese Oral Cancer Patients' Pain Beliefs: An Application of Leventhal's Common-Sense Model.

BACKGROUND: Patients' pain beliefs are the main obstacle to effective pain management. Assessing and correcting negative perceptions is important for improving pain intensity and quality of life of patients with cancer pain. AIMS: To explore pain beliefs among oral cancer patients using the Common-Sense Model of Self-Regulation as a theoretical framework. The primary components of the model, cognitive representations, emotional representations, and coping responses, were examined. DESIGN: A qualitative method was used. SETTINGS: PARTICIPANTS/SUBJECTS:   METHODS: Semi-structured, qualitative, in-depth interviews were conducted with patients newly diagnosed with oral cancer in a tertiary care hospital. The interviews were analyzed using thematic analysis. RESULTS: Interviews with 15 patients revealed that the pain beliefs of patients with oral cancer included three themes: pain cognitive representations of oral cancer, pain emotional representations of oral cancer, and pain coping responses. CONCLUSIONS: Negative pain beliefs are common among oral cancer patients. This novel application of the self-regulatory model demonstrates that it can be used to capture the key pain beliefs (i.e., cognitions, emotions, and coping responses) of oral cancer patients within a single, unifying framework.

The development of a Cancer Pain Belief Modification Program for patients with oral cancer in China: a feasibility study.

BACKGROUND: Acceptance-based pain management interventions have been receiving growing attention in cancer pain care. This study aimed to develop a cancer pain management program based on belief modification to improve the cancer pain experience of Chinese oral cancer survivors and to explore the acceptability and preliminary outcomes of the Cancer Pain Belief Modification Program (CPBMP). METHODS: A mixed-methods approach was applied to develop and revise the program. The CPBMP was developed and revised using the Delphi technique, and its further improvement was explored with a one-group pre- and post-trial designed with a sample of 16 Chinese oral cancer survivors, and semi-structured interviews. Research instruments included Numeric Rating Scale (NRS), Chinese version of Illness Perception Questionnaire-Revised for Cancer Pain (IPQ-CaCP), and the University of Washington Quality of Life assessment scale (UW-QOL). Descriptive statistics, t-test, and Mann-Whitney U test were used to analyse the data. The semi-structured questions were analysed using content analysis. RESULTS: The six-module CPBMP was endorsed by most experts and patients. The expert authority coefficient value was 0.75 in the first round of the Delphi survey and 0.78 in the second round. The "pain intense", "negative pain beliefs" scores of pre- and post-testing decreased from 5.63 ± 0.48 to 0.81 ± 0.54 (t = -3.746, p < 0.001); from 140.63 ± 9.02 to 52.75 ± 7.27 (Z = 12.406, p < 0.001); and the "positive pain beliefs", "quality of life" scores increased from 55.13 ± 4.54 to 66.00 ± 4.70 (Z = -6.983, p < 0.001); from 66.97 ± 15.01 to 86.69 ± 8.42 (Z = 7.283, p < 0.001). The qualitative data also indicated that CPBMP was well acceptable. CONCLUSION: Our study showed the acceptability and preliminary outcomes of CPBMP patients. CPBMP improves the pain experience of Chinese oral cancer patients and provides a reference for cancer pain management in the future. TRIAL REGISTRATION: The feasibility study has already been registered on the Chinese Clinical Trial Registry (ChiCTR) ( www.chictr.org.cn ) in 11/09/2021. (ChiCTR2100051065).

Effect of Core Density on the Three-Point Bending Performance of Aluminum Foam Sandwich Panels.

Using the powder-metallurgy rolling method, aluminum foam sandwich (AFS) panels with a metallurgical bond between the foam core and the panel can be produced. In this study, by manipulating the foaming temperature and duration, AFS panels were fabricated with varying core densities and thicknesses, all maintaining a panel thickness close to 1 mm. Through the three-point bending test, this research deeply delved into how core density influences the mechanical behaviors of these AFS panels. It became evident that a rise in core density positively affects the bending strength and failure load of the panels but inversely impacts their total energy absorption efficiency. Differing core densities brought about distinct failure patterns: low-density samples primarily showed panel indentation and core shear failures, whereas those of high density demonstrated panel yield and fractures. Furthermore, the research offers predictions on the initial failure loads for different failure modes and introduces a comprehensively designed failure diagram, laying a foundational theory for the production of AFS panels.

Investigation of the Indentation Resistance of Aluminum Foam Sandwich Panels with Metallurgical Bonding Interfaces under Low-Velocity Impact.

The impact resistance of aluminum foam sandwich panels (AFS) with metallurgical bonding interfaces prepared by the powder cladding rolling method was investigated. Low-velocity impact tests were conducted by using a drop-weight impact facility to explore the dynamic mechanical behavior, deformation and damage mechanisms, and energy absorption of AFS with metallurgical bonding interfaces. The effects of variation of impact energy, panel thickness, and specimen density on the energy absorption performance of AFS were quantitatively evaluated by energy absorption indicators. The results indicate that the load-displacement curve illustrates prominent three-stage characteristics when the impact energy is 120 J containing the front panel yielding stage, the foam core's compressive and shear failure stage, and the back panel fracture stage. The impact strength of the sandwich structure increases with increasing panel thickness and specimen density. The AFS with metallurgical bonding interfaces presents favorable energy absorption efficiency under low velocity.

Aluminum Foam Sandwich: Pore Evolution Mechanism Investigation and Engineering Preparing Optimization.

This paper employs an innovative investigation approach to study pore evolution in Al-Si-Mg-Cu alloy within aluminum foam sandwiches (AFS) by integrating data from heating-expansion ratio curves, in situ observation of synchronous radiation, and microscopic analysis of the matrix's microstructure at different stages. Additionally, the cavity design and plate type control for large-scale AFS production are explored. Findings categorize the precursor heating into three stages: rapid heating, solid-liquid transition, and stable foaming. During solid-liquid transition, the expansion rate experiences a sudden drop, associated with pore nucleation and edge cracking of precursors. Pores nucleate as elongated crack-like structures along the rolling direction, guided by the Mg-enriched regions. In stable foaming, these pores evolve, become spherical, and the matrix rapidly expands. Using square tubes for sealing on the preform cavity sides creates a dense edge zone during rolling, halting crack propagation into the powder core. Adopting edge sealing during foaming mitigates boundary effects, thereby improving AFS panel flatness.

Three-Point Bending Behavior of Aluminum Foam Sandwich with Different Interface Bonding Methods.

The interface bonding method has a great influence on the mechanical properties of aluminum foam sandwich (AFS). This study aims to investigate the effect of different interface bonding methods on the mechanical properties of AFS. In this paper, the metallurgical-bonding interface-formation mechanism of AFS prepared by powder metallurgy was investigated. The shear properties of metallurgical-bonded AFS were determined by the panel peeling test. The flexural properties and energy absorption of metallurgical-bonded and glued AFS were analyzed through the three-point bending test. The results show that the magnesium, silicon, and copper elements of the core layer diffuse to panels and form a metallurgical composite layer. The metallurgical-bonding strength between the panel and core layer is higher than that of the foam core layer. The peak load of metallurgically-bonded AFS is 24% more than that of glued AFS, and energy absorption is 12.2 times higher than that of glued AFS.

A new non-muscle-invasive bladder tumor-homing peptide identified by phage display in vivo.

Bladder cancer is common and widespread, and its incidence is increasing. Many new diagnostic methods combined with state-of-the-art technology have been introduced in cystoscopy to collect real-time images of the bladder mucosa for diagnosis, but often miss inconspicuous early-stage tumors. Fluorophore-labeled peptides with high sensitivity and specificity for cancer would be a desirable tool for the detection and treatment of tiny or residual bladder tumors. Phage display and the human non-muscle-invasive bladder cancer cell line BIU-87 were used to identify a peptide. The isolated phage display peptide (CSSPIGRHC, named NYZL1) was tested in vitro for its binding specificity and affinity. Accumulation into xenograft tumors in a nude mouse model was analyzed with FITC-labeled NYZL1. NYZL1, with strong tumor­homing ability, was identified by in vivo phage library selection in the bladder cancer model. The NYZL1 phage and synthetic FITC-labeled NYZL1 peptides bound to tumor tissues and cells, but were hardly detected in normal control organs. Notably, accumulation of FITC-NYZL1 in bladder tumor cells was time-dependent. Biodistribution studies of xenografts of BIU-87 cells showed accumulation of injected FITC-NYZL1 in the tumors, and the bound peptide could not be removed by perfusion after 24 h. The mouse model of bladder tumor showed increased fluorescence intensity in the tumor-bearing bladder in comparison with normal bladder tissues after 4-6 h. In conclusion, NYZL1 may represent a lead peptide structure applicable in the development of optical molecular imaging.