Detalhe da pesquisa
1.
B56δ long-disordered arms form a dynamic PP2A regulation interface coupled with global allostery and Jordan's syndrome mutations.
Proc Natl Acad Sci U S A
; 121(1): e2310727120, 2024 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38150499
2.
Quantitative proteomics and phosphoproteomics of PP2A-PPP2R5D variants reveal deregulation of RPS6 phosphorylation via converging signaling cascades.
J Biol Chem
; 299(9): 105154, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37572851
3.
A disorder-related variant (E420K) of a PP2A-regulatory subunit (PPP2R5D) causes constitutively active AKT-mTOR signaling and uncoordinated cell growth.
J Biol Chem
; 296: 100313, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33482199
4.
PP1:Tautomycetin Complex Reveals a Path toward the Development of PP1-Specific Inhibitors.
J Am Chem Soc
; 139(49): 17703-17706, 2017 12 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-29156132
5.
Quantum-based modeling implies that bidentate Arg89-substrate binding enhances serine/threonine protein phosphatase-2A(PPP2R5D/PPP2R1A/PPP2CA)-mediated dephosphorylation.
Front Cell Dev Biol
; 11: 1141804, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37377738
6.
Extended regulation interface coupled to the allosteric network and disease mutations in the PP2A-B56δ holoenzyme.
bioRxiv
; 2023 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37066309
7.
Cardioprotection by mild hypothermia during ischemia involves preservation of ERK activity.
Basic Res Cardiol
; 106(3): 421-30, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21399968
8.
Phosphatase inhibition by LB-100 enhances BMN-111 stimulation of bone growth.
JCI Insight
; 6(9)2021 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33986191
9.
Total synthesis and evaluation of phostriecin and key structural analogues.
J Org Chem
; 75(22): 7505-13, 2010 Nov 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-20669916
10.
Structure-activity relationship studies of fostriecin, cytostatin, and key analogs, with PP1, PP2A, PP5, and( beta12-beta13)-chimeras (PP1/PP2A and PP5/PP2A), provide further insight into the inhibitory actions of fostriecin family inhibitors.
J Pharmacol Exp Ther
; 331(1): 45-53, 2009 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-19592665
11.
Inhibitors of Serine/Threonine Protein Phosphatases: Biochemical and Structural Studies Provide Insight for Further Development.
Curr Med Chem
; 26(15): 2634-2660, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-29737249
12.
Development of a Synthetic 3-ketosteroid Δ1-dehydrogenase for the Generation of a Novel Catabolic Pathway Enabling Cholesterol Degradation in Human Cells.
Sci Rep
; 9(1): 5969, 2019 04 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30979909
13.
The Antitumor Drug LB-100 Is a Catalytic Inhibitor of Protein Phosphatase 2A (PPP2CA) and 5 (PPP5C) Coordinating with the Active-Site Catalytic Metals in PPP5C.
Mol Cancer Ther
; 18(3): 556-566, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30679389
14.
High yield expression of serine/threonine protein phosphatase type 5, and a fluorescent assay suitable for use in the detection of catalytic inhibitors.
Assay Drug Dev Technol
; 5(5): 645-53, 2007 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17939754
15.
Small-molecule inhibitors of ser/thr protein phosphatases: specificity, use and common forms of abuse.
Methods Mol Biol
; 365: 23-38, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17200551
16.
An Ultra-High-Throughput Screen for Catalytic Inhibitors of Serine/Threonine Protein Phosphatases Types 1 and 5 (PP1C and PP5C).
SLAS Discov
; 22(1): 21-31, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27628691
17.
Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C.
Biochem Pharmacol
; 109: 14-26, 2016 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27002182
18.
Development and validation of a robust and sensitive assay for the discovery of selective inhibitors for serine/threonine protein phosphatases PP1α (PPP1C) and PP5 (PPP5C).
Assay Drug Dev Technol
; 12(8): 481-96, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25383722
19.
The role of serine/threonine protein phosphatase type 5 (PP5) in the regulation of stress-induced signaling networks and cancer.
Cancer Metastasis Rev
; 27(2): 169-78, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18253812
20.
Total synthesis and evaluation of cytostatin, its C10-C11 diastereomers, and additional key analogues: impact on PP2A inhibition.
J Am Chem Soc
; 128(51): 16720-32, 2006 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-17177422