Detalhe da pesquisa
1.
JAK inhibition with tofacitinib suppresses arthritic joint structural damage through decreased RANKL production.
Arthritis Rheum
; 64(11): 3531-42, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22899318
2.
The Interleukin-1 Receptor-Associated Kinase 4 Inhibitor PF-06650833 Blocks Inflammation in Preclinical Models of Rheumatic Disease and in Humans Enrolled in a Randomized Clinical Trial.
Arthritis Rheumatol
; 73(12): 2206-2218, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34423919
3.
Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841).
J Med Chem
; 61(19): 8597-8612, 2018 10 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30113844
4.
Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases.
J Med Chem
; 61(3): 1130-1152, 2018 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29298069
5.
Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design.
J Med Chem
; 60(13): 5521-5542, 2017 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28498658
6.
Immediate sensory nerve-mediated respiratory responses to irritants in healthy and allergic airway-diseased mice.
J Appl Physiol (1985)
; 94(4): 1563-71, 2003 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-12626476
7.
Lack of role for the vanilloid receptor in response to several inspired irritant air pollutants in the C57Bl/6J mouse.
Neurosci Lett
; 362(2): 150-3, 2004 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-15193774
8.
Effect of nitrogen dioxide on ovalbumin-induced allergic airway disease in a murine model.
J Toxicol Environ Health A
; 65(23): 1999-2005, 2002 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-12490044