RESUMO
Intoxication of rats with mercuric chloride (0.5 mg Hg/kg of body weight, daily for 10 weeks) increased the hepatic contents of soluble and insoluble collagen and elastin. The increase was associated with elevated serum aminotransferase and alkaline phosphatase activities, and decreased total protein level in serum. Inflammatory changes were found in the liver. An increase in the fibrous protein content suggests that inflammatory reaction to mercuric chloride can result in hepatic fibrosis.
Assuntos
Colágeno/metabolismo , Elastina/metabolismo , Fígado/metabolismo , Cloreto de Mercúrio/intoxicação , Animais , Fígado/efeitos dos fármacos , Masculino , Ratos , Ratos EndogâmicosRESUMO
The paper is aimed at quantitative and qualitative determination of acrylic compounds that may occur in air at the "Lentex" Plant in Lubliniec, along with microclimate parameters measurements. The initial method was that of the Polish Standard PN-78/z-04113, which was subsequently modified. Pursuant to this standard, acrylic compounds were determined by gas chromatography with new column pack and changed parameters of gas chromatograph. The conditions of acrylic esters and acrylonitrile separation on column with LAC-1R-296 phase were considered the best and were used for quantitative and qualitative estimation. The investigations were carried out at workstations, basing on the production stage. The obtained results of identified acrylates concentrations are indicative of a very little content of those compounds in workstations air, implying that those workstations are safe in respect of chemical risk to workers. Certain deviations from mandatory standards were exhibited by almost all microclimatic parameters which might result in workers' worse general feeling.