Detalhe da pesquisa
1.
Microsomal prostaglandin E synthase type 2 (mPGES2) is a glutathione-dependent heme protein, and dithiothreitol dissociates the bound heme to produce active prostaglandin E2 synthase in vitro.
J Biol Chem
; 288(14): 10166-10175, 2013 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-23426368
2.
A catalytic mechanism that explains a low catalytic activity of serine dehydratase like-1 from human cancer cells: crystal structure and site-directed mutagenesis studies.
Biochim Biophys Acta
; 1780(5): 809-18, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18342636
3.
Cloning, bacterial expression, and unique structure of adenosylhomocysteine hydrolase-like protein 1, or inositol 1,4,5-triphosphate receptor-binding protein from mouse kidney.
Biochim Biophys Acta
; 1784(11): 1786-94, 2008 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-18804558
4.
An investigation of the catalytic mechanism of S-adenosylmethionine synthetase by QM/MM calculations.
Arch Biochem Biophys
; 492(1-2): 82-92, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19699176
5.
Enzymatic and biochemical properties of a novel human serine dehydratase isoform.
Biochim Biophys Acta
; 1764(5): 961-71, 2006 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-16580895
6.
Structure and function of eritadenine and its 3-deaza analogues: potent inhibitors of S-adenosylhomocysteine hydrolase and hypocholesterolemic agents.
Biochem Pharmacol
; 73(7): 981-9, 2007 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17214973
7.
Variation of loop sequence alters stability of cytolethal distending toxin (CDT): crystal structure of CDT from Actinobacillus actinomycetemcomitans.
Protein Sci
; 15(2): 362-72, 2006 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-16434747
8.
Crystal structure and possible catalytic mechanism of microsomal prostaglandin E synthase type 2 (mPGES-2).
J Mol Biol
; 348(5): 1163-76, 2005 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-15854652
9.
Catalytic mechanism of S-adenosylhomocysteine hydrolase: roles of His 54, Asp130, Glu155, Lys185, and Aspl89.
Int J Biochem Cell Biol
; 37(11): 2417-35, 2005 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-16061414
10.
Some biochemical and histochemical properties of human liver serine dehydratase.
Int J Biochem Cell Biol
; 37(3): 574-89, 2005 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-15618015
11.
Crystal structure of guanidinoacetate methyltransferase from rat liver: a model structure of protein arginine methyltransferase.
J Mol Biol
; 320(2): 223-35, 2002 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-12079381
12.
Evidence for a dimeric structure of rat liver serine dehydratase.
Int J Biochem Cell Biol
; 34(5): 533-43, 2002 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-11906824
13.
Localization and hormonal control of serine dehydratase during metabolic acidosis differ markedly from those of phosphoenolpyruvate carboxykinase in rat kidney.
Int J Biochem Cell Biol
; 35(8): 1234-47, 2003 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-12757760
14.
[Structure, function, and stability of cytolethal distending toxin].
Seikagaku
; 79(4): 350-4, 2007 Apr.
Artigo
em Japonês
| MEDLINE | ID: mdl-17511253
15.
Discovery of novel types of inhibitors of S-adenosylmethionine synthesis by virtual screening.
J Med Chem
; 52(19): 5967-73, 2009 Oct 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-19739644
16.
PGH2 degradation pathway catalyzed by GSH-heme complex bound microsomal prostaglandin E2 synthase type 2: the first example of a dual-function enzyme.
Biochemistry
; 46(28): 8414-24, 2007 Jul 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-17585783
17.
Prostaglandin F2alpha formation from prostaglandin H2 by prostaglandin F synthase (PGFS): crystal structure of PGFS containing bimatoprost.
Biochemistry
; 45(7): 1987-96, 2006 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-16475787
18.
Crystal structure of human prostaglandin F synthase (AKR1C3).
Biochemistry
; 43(8): 2188-98, 2004 Mar 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-14979715
19.
The active site loop of S-adenosylmethionine synthetase modulates catalytic efficiency.
Biochemistry
; 41(30): 9358-69, 2002 Jul 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-12135357
20.
Crystal structure of the S-adenosylmethionine synthetase ternary complex: a novel catalytic mechanism of S-adenosylmethionine synthesis from ATP and Met.
Biochemistry
; 43(7): 1821-31, 2004 Feb 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-14967023