Detalhe da pesquisa
1.
Synthesis and biological evaluation of thieno[3,2-c]pyrazol-3-amine derivatives as potent glycogen synthase kinase 3ß inhibitors for Alzheimer's disease.
Bioorg Chem
; 138: 106663, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37329814
2.
Synthesis and biological evaluation of thieno[3,2-c]pyrazol-3-amine derivatives as potent glycogen synthase kinase 3ß inhibitors for Alzheimer's disease.
J Enzyme Inhib Med Chem
; 37(1): 1724-1736, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-35698879
3.
Tubulin colchicine site binding agent LL01 displays potent antitumor efficiency both in vitro and in vivo with suitable drug-like properties.
Invest New Drugs
; 38(1): 29-38, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30887253
4.
Synthesis and Evaluation of Novel 2H-Benzo[e]-[1,2,4]thiadiazine 1,1-Dioxide Derivatives as PI3Kδ Inhibitors.
Molecules
; 24(23)2019 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-31775363
5.
Synthesis of Novel Pyrazole Derivatives and Their Tumor Cell Growth Inhibitory Activity.
Molecules
; 24(2)2019 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30642134
6.
Preparation of S14161 and its analogues and the discovery of 6-bromo-8-ethoxy-3-nitro-2H-chromene as a more potent antitumor agent in vitro.
Bioorg Med Chem Lett
; 23(11): 3314-9, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23601711
7.
Synthesis and evaluation of trehalose-based compounds as anti-invasive agents.
Bioorg Med Chem Lett
; 21(4): 1089-91, 2011 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21269828
8.
Design and synthesis of potent HIV-1 protease inhibitors incorporating hydroxyprolinamides as novel P2 ligands.
Bioorg Med Chem Lett
; 21(12): 3730-3, 2011 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21555220
9.
The discovery of novel indazole derivatives as tubulin colchicine site binding agents that displayed potent antitumor activity both in vitro and in vivo.
Eur J Med Chem
; 187: 111968, 2020 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31865012
10.
SAR Investigation and Discovery of Water-Soluble 1-Methyl-1,4-dihydroindeno[1,2-c]pyrazoles as Potent Tubulin Polymerization Inhibitors.
J Med Chem
; 63(23): 14840-14866, 2020 12 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33201714
11.
Discovery of novel quinazolinone derivatives as high potent and selective PI3Kδ and PI3Kδ/γ inhibitors.
Eur J Med Chem
; 151: 9-17, 2018 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29601991
12.
Design, Synthesis, and Biological Evaluation of 1-Methyl-1,4-dihydroindeno[1,2-c]pyrazole Analogues as Potential Anticancer Agents Targeting Tubulin Colchicine Binding Site.
J Med Chem
; 59(11): 5341-55, 2016 06 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27172319
13.
Recoverable Pd/C catalyst mediated dehydrogenation of sterols and an improved synthesis of 1α-hydroxydehydroepiandrosterone.
Steroids
; 77(13): 1419-22, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-23000152