RESUMO
In this study, we present a novel low-frequency electrical stimulation paradigm for mesial temporal lobe epilepsy (MTLE). The paradigm utilizes the hippocampal commissure as a unique stimulation target to simultaneously influence large portions of the bilateral hippocampal network. When applied to an acute rat model of MTLE, animals that received stimulation exhibited an 88% reduction in the signal power of the bilateral epileptiform activity relative to the control group. In addition, the stimulation entrained the hippocampal network's spontaneous epileptiform activity and disrupted its bilateral synchrony.
Assuntos
Estimulação Elétrica/métodos , Epilepsia do Lobo Temporal/terapia , 4-Aminopiridina/toxicidade , Animais , Biofísica , Modelos Animais de Doenças , Epilepsia do Lobo Temporal/induzido quimicamente , Epilepsia do Lobo Temporal/patologia , Lateralidade Funcional , Hipocampo/efeitos dos fármacos , Hipocampo/fisiopatologia , Bloqueadores dos Canais de Potássio/toxicidade , Ratos , Fatores de TempoRESUMO
Extracting physiological signals to control external devices such as prosthetics is a field of research that offers great hope for patients suffering from disabilities. In this paper, a novel source signal extraction algorithm, based on the source localization method Champagne, is presented. The algorithm constructs spatial filters that not only maximizes the signal to noise ratio (SNR > 13 dB) of the source activities but also minimizes the cross-talk interference between the sources 10log((P(source of interest)/P(interference sources)) > 14 dB.