Detalhe da pesquisa
1.
Baseline Clinical Characteristics and Complement Biomarkers of Patients with C3 Glomerulopathy Enrolled in Two Phase 2 Studies Investigating the Factor D Inhibitor Danicopan.
Am J Nephrol
; 53(10): 675-686, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36404708
2.
Small-molecule factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome.
Haematologica
; 102(3): 466-475, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-27810992
3.
Mechanistic assessment of DNA ligase as an antibacterial target in Staphylococcus aureus.
Antimicrob Agents Chemother
; 56(8): 4095-102, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22585221
4.
Bactericidal activity of ACH-702 against nondividing and biofilm Staphylococci.
Antimicrob Agents Chemother
; 56(7): 3812-8, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22547614
5.
Syntheses and biological studies of novel spiropiperazinyl oxazolidinone antibacterial agents using a spirocyclic diene derived acylnitroso Diels-Alder reaction.
Bioorg Med Chem
; 20(11): 3422-8, 2012 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22560837
6.
In vitro and in vivo profiles of ACH-702, an isothiazoloquinolone, against bacterial pathogens.
Antimicrob Agents Chemother
; 55(6): 2860-71, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21464250
7.
In vitro antituberculosis activities of ACH-702, a novel isothiazoloquinolone, against quinolone-susceptible and quinolone-resistant isolates.
Antimicrob Agents Chemother
; 54(8): 3478-80, 2010 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-20516287
8.
Isothiazoloquinolones with enhanced antistaphylococcal activities against multidrug-resistant strains: effects of structural modifications at the 6-, 7-, and 8-positions.
J Med Chem
; 50(2): 199-210, 2007 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-17228862
9.
Isothiazolopyridones: synthesis, structure, and biological activity of a new class of antibacterial agents.
J Med Chem
; 49(1): 39-42, 2006 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-16392790
10.
Identification of 113 conserved essential genes using a high-throughput gene disruption system in Streptococcus pneumoniae.
Nucleic Acids Res
; 30(14): 3152-62, 2002 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-12136097
11.
Selenophene-containing inhibitors of type IIA bacterial topoisomerases.
J Med Chem
; 54(9): 3418-25, 2011 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-21443219
12.
One-step syntheses of nitrofuranyl benzimidazoles that are active against multidrug-resistant bacteria.
J Antibiot (Tokyo)
; 64(10): 667-671, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21811261
13.
Exploration of the activity of 7-pyrrolidino-8-methoxyisothiazoloquinolones against methicillin-resistant Staphylococcus aureus (MRSA).
J Med Chem
; 54(9): 3268-82, 2011 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-21425851
14.
Dual targeting of DNA gyrase and topoisomerase IV: target interactions of heteroaryl isothiazolones in Staphylococcus aureus.
Antimicrob Agents Chemother
; 51(7): 2445-53, 2007 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-17502409
15.
In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens.
Antimicrob Agents Chemother
; 51(4): 1259-67, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17242152
16.
Small molecule inhibitors of E. coli primase, a novel bacterial target.
Bioorg Med Chem Lett
; 17(10): 2807-10, 2007 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17350255
17.
Biological evaluation of isothiazoloquinolones containing aromatic heterocycles at the 7-position: In vitro activity of a series of potent antibacterial agents that are effective against methicillin-resistant Staphylococcus aureus.
Bioorg Med Chem Lett
; 16(5): 1277-81, 2006 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16337789
18.
Isothiazoloquinolones containing functionalized aromatic hydrocarbons at the 7-position: synthesis and in vitro activity of a series of potent antibacterial agents with diminished cytotoxicity in human cells.
Bioorg Med Chem Lett
; 16(5): 1272-6, 2006 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16337791