Detalhe da pesquisa
1.
A small molecule with anticancer and antimetastatic activities induces rapid mitochondrial-associated necrosis in breast cancer.
J Pharmacol Exp Ther
; 353(2): 392-404, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25720766
2.
The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents.
Bioorg Med Chem
; 22(14): 3753-72, 2014 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24890652
3.
Solid phase synthesis and biological evaluation of probestin as an angiogenesis inhibitor.
Bioorg Med Chem Lett
; 23(12): 3561-4, 2013 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23664876
4.
N2-Trimethylacetyl substituted and unsubstituted-N4-phenylsubstituted-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines: design, cellular receptor tyrosine kinase inhibitory activities and in vivo evaluation as antiangiogenic, antimetastatic and antitumor agents.
Bioorg Med Chem
; 21(5): 1312-23, 2013 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23375090
5.
Synthesis and biological activity of 5-chloro-N4-substituted phenyl-9H-pyrimido[4,5-b]indole-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic agents.
Bioorg Med Chem
; 21(7): 1857-64, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23434139
6.
N4-(3-Bromophenyl)-7-(substituted benzyl) pyrrolo[2,3-d]pyrimidines as potent multiple receptor tyrosine kinase inhibitors: design, synthesis, and in vivo evaluation.
Bioorg Med Chem
; 20(7): 2444-54, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22370340
7.
N4-Aryl-6-substitutedphenylmethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as receptor tyrosine kinase inhibitors.
Bioorg Med Chem
; 20(2): 910-4, 2012 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22204741
8.
Novel tricyclic indeno[2,1-d]pyrimidines with dual antiangiogenic and cytotoxic activities as potent antitumor agents.
Bioorg Med Chem
; 20(14): 4217-25, 2012 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22739090
9.
Synthesis and biological activity of N(4)-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic and antitumor agents.
Bioorg Med Chem
; 18(10): 3575-87, 2010 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20403700
10.
Clinical review 2: The "metabolic memory": is more than just tight glucose control necessary to prevent diabetic complications?
J Clin Endocrinol Metab
; 94(2): 410-5, 2009 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-19066300
11.
Design, synthesis and biological evaluation of substituted pyrrolo[2,3-d]pyrimidines as multiple receptor tyrosine kinase inhibitors and antiangiogenic agents.
Bioorg Med Chem
; 16(10): 5514-28, 2008 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18467105
12.
Laboratory diet profoundly alters gene expression and confounds genomic analysis in mouse liver and lung.
Chem Biol Interact
; 173(2): 129-40, 2008 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-18396267
13.
Transition from androgenic to neurosteroidal action of 5α-androstane-3α, 17ß-diol through the type A γ-aminobutyric acid receptor in prostate cancer progression.
J Steroid Biochem Mol Biol
; 178: 89-98, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29155210
14.
Mutant p53 facilitates pro-angiogenic, hyperproliferative phenotype in response to chronic relative hypoxia.
Cancer Lett
; 249(2): 209-19, 2007 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-16997458
15.
Exposure to arsenic at levels found inU.S. drinking water modifies expression in the mouse lung.
Toxicol Sci
; 100(1): 75-87, 2007 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17682005
16.
A long-term "memory" of HIF induction in response to chronic mild decreased oxygen after oxygen normalization.
BMC Cardiovasc Disord
; 7: 4, 2007 Jan 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-17233898
17.
Discovery of antitubulin agents with antiangiogenic activity as single entities with multitarget chemotherapy potential.
ACS Med Chem Lett
; 5(5): 480-4, 2014 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900865
18.
Development and characterization of a preclinical model of breast cancer lung micrometastatic to macrometastatic progression.
PLoS One
; 9(5): e98624, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24878664
19.
Chronic exposure to arsenic in the drinking water alters the expression of immune response genes in mouse lung.
Environ Health Perspect
; 117(7): 1108-15, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19654921
20.
Oscillating glucose is more deleterious to endothelial function and oxidative stress than mean glucose in normal and type 2 diabetic patients.
Diabetes
; 57(5): 1349-54, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18299315