Detalhe da pesquisa
1.
Loss-of-Function and Gain-of-Function Mutations in KCNQ5 Cause Intellectual Disability or Epileptic Encephalopathy.
Am J Hum Genet
; 101(1): 65-74, 2017 Jul 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28669405
2.
Stabilization of the Activated hERG Channel Voltage Sensor by Depolarization Involves the S4-S5 Linker.
Biophys J
; 112(2): 300-312, 2017 Jan 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28122216
3.
NS1643 interacts around L529 of hERG to alter voltage sensor movement on the path to activation.
Biophys J
; 108(6): 1400-1413, 2015 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-25809253
4.
Proline scan of the HERG channel S6 helix reveals the location of the intracellular pore gate.
Biophys J
; 106(5): 1057-69, 2014 Mar 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-24606930
5.
Molecular Pharmacology of Selective NaV1.6 and Dual NaV1.6/NaV1.2 Channel Inhibitors that Suppress Excitatory Neuronal Activity Ex Vivo.
ACS Chem Neurosci
; 15(6): 1169-1184, 2024 03 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38359277
6.
Mechanistic insight into human ether-à-go-go-related gene (hERG) K+ channel deactivation gating from the solution structure of the EAG domain.
J Biol Chem
; 286(8): 6184-91, 2011 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-21135103
7.
Pharmacological determination of the fractional block of Nav channels required to impair neuronal excitability and ex vivo seizures.
Front Cell Neurosci
; 16: 964691, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36246527
8.
Kv1.1 channels mediate network excitability and feed-forward inhibition in local amygdala circuits.
Sci Rep
; 11(1): 15180, 2021 07 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34312446
9.
Modulation of hERG K+ Channel Deactivation by Voltage Sensor Relaxation.
Front Pharmacol
; 11: 139, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32184724
10.
Extracellular protons accelerate hERG channel deactivation by destabilizing voltage sensor relaxation.
J Gen Physiol
; 151(2): 231-246, 2019 02 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30530765
11.
The X-Linked Intellectual Disability Gene Zdhhc9 Is Essential for Dendrite Outgrowth and Inhibitory Synapse Formation.
Cell Rep
; 29(8): 2422-2437.e8, 2019 11 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-31747610
12.
Investigating the state dependence of drug binding in hERG channels using a trapped-open channel phenotype.
Sci Rep
; 8(1): 4962, 2018 03 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-29563525