Clinical value of Tc-99m MDP SPECT/CT bone imaging for early diagnosis of Relapsing Polychondritis: a report of 5 cases.

BACKGROUND: Relapsing Polychondritis(RP) is a rare rheumatic immune disease. As with most diseases, if intervention is delayed, the patient's prognosis is worse. Currently, the diagnostic criteria used in clinical practice do not include CT, PET/CT, SPECT/CT and other new imaging examinations that have developed rapidly in recent years. However, these examinations have some special manifestations for RP, which can help clinicians diagnose RP earlier and distinguish it from other diseases. CASE PRESENTATION: These five RP patients all had respiratory symptoms such as cough and wheezing as the first symptom, which could not be diagnosed in time according to the previous diagnostic criteria. The clinical data of the five patients are listed in Table 1. The relatively specific manifestations of SPECT/CT examination provided clinicians with very valuable clues to help them advance the diagnosis time. CONCLUSIONS: The application of SPECT/CT bone imaging in early diagnosing RP proves to be effective, enabling clinicians to intervene promptly and enhance the overall well-being and quality of life for individuals affected by this condition.

Experimental and DFT characterization of metal-to-ligand charge-transfer excited states of (rutheniumammine)(monodentate aromatic ligand) chromophores.

The heretofore unknown emission properties of the metal-to-ligand charge-transfer (MLCT) excited states of several complexes with (ruthenium)(monodentate aromatic ligand, MDA) chromophores are given. Emission spectra and lifetimes in 77 K glasses are reported for several monometallic complexes of the type [Ru(NH3)(5-n)(L)(n)(MDA)](2+) and two bimetallic pyrazine (pz)-bridged [{Ru(NH3)(4-n)(L)(n)}2pz](4+) complexes (L = pz, pyridine, or a multipyridine ligand; MDA = pz or a substituted pyridine, Y-py). The emission maxima occur in the visible and near-IR spectral regions and have much more poorly resolved vibronic sidebands than do related complexes with Ru-bpy chromophores, and the excited-state lifetimes are characteristic of Ru-bpy MLCT excited states in this energy range. The emission yields of trans-[Ru(NH3)4(MDA)(pz)](2+) (MDA = py or pz) are less than 0.2%, and combined with the other observations, this implies that most of the excited-state quenching occurs in high-energy excited states whose population precedes that of the lowest-energy (3)MLCT excited state. The pz-bridged, bimetallic complexes have mixed-valence excited states, and they absorb and emit at lower energies than their monometallic analogues do.

Porcine Hemagglutinating Encephalomyelitis Virus Co-Opts Multivesicular-Derived Exosomes for Transmission.

Porcine hemagglutinating encephalomyelitis virus (PHEV) is a member of the family Coronaviridae, genus Betacoronavirus, and subgenus Embecovirus that causes neurological disorders, vomiting and wasting disease (VWD), or influenza-like illness (ILI) in pigs. Exosomes regulate nearby or distant cells as a means of intercellular communication; however, whether they are involved in the transmission of viral reference materials during PHEV infection is unknown. Here, we collected exosomes derived from PHEV-infected neural cells (PHEV-exos) and validated their morphological, structural, and content characteristics. High-resolution mass spectrometry indicated that PHEV-exos carry a variety of cargoes, including host innate immunity sensors and viral ingredients. Furthermore, transwell analysis revealed that viral ingredients, such as proteins and RNA fragments, could be encapsulated in the exosomes of multivesicular bodies (MVBs) to nonpermissive microglia. Inhibition of exosome secretion could suppress PHEV infection. Therefore, we concluded that the mode of infectious transmission of PHEV is likely through a mixture of virus-modified exosomes and virions and that exosomal export acts as a host strategy to induce an innate response in replicating nonpermissive bystander cells free of immune system recognition. IMPORTANCE The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a large number of deaths worldwide. Clinical neurological complications have occurred in some cases; however, knowledge of the natural history of coronavirus in the central nervous system (CNS) is thus far limited. PHEV is a typical neurotropic betacoronavirus (ß-CoV) that propagates via neural circuits in the host CNS after peripheral incubation rather than through the bloodstream. It is therefore a good prototype pathogen to investigate the neuropathological pathogenesis of acute human coronavirus infection. In this study, we demonstrate a new association between host vesicle-based secretion and PHEV infection, showing that multivesicular-derived exosomes are one of the modes of infectious transmission and that they mediate the transfer of immunostimulatory cargo to uninfected neuroimmune cells. These findings provide novel insights into the treatment and monitoring of neurological consequences associated with ß-CoV, similar to those associated with SARS-CoV-2.

Relationship quality and exhibitors' sustainable willingness to participate in exhibitions: A sociocultural perspective.

Exhibition is a new economic business form in China. From a stakeholder perspective, all important roles in the context of hospitality and tourism are talents. From a socio-cultural perspective, interpersonal relationship quality plays a vital role in business and industrial operations. This constructs a causal model of relationship quality between exhibitors and exhibition organizers, and examined its influence on exhibitors' willingness to sustainably participate in exhibitions. Data collected from a total of 251 exhibitors from 4 nation-representative exhibitions in Beijing were analyzed. The results found that the four antecedent variables-guanxi (as distinctive from relationship quality), service quality, communication, and exhibition effectiveness-have significant impacts on the relationship quality between exhibitors and exhibition organizers, which in turn, affect exhibitors' willingness to participate in subsequent exhibitions (i.e., exhibitor loyalty). These findings provide a theoretical basis and policy recommendations talent management in exhibition context.