Saccadic eye movements estimate prolonged time awake.

Prolonged time awake increases the need to sleep. Sleep pressure increases sleepiness, impairs human alertness and performance and increases the probability of human errors and accidents. Human performance and alertness during waking hours are influenced by homeostatic sleep drive and the circadian rhythm. Cognitive functions, especially attentional ones, are vulnerable to circadian rhythm and increasing sleep drive. A reliable, objective and practical metrics for estimating sleepiness could therefore be valuable. Our aim is to study whether saccades measured with electro-oculography (EOG) outside the laboratory could be used to estimate the overall time awake without sleep of a person. The number of executed saccades was measured in 11 participants during an 8-min saccade task. The saccades were recorded outside the laboratory (Naval Academy, Bergen) using EOG every sixth hour until 54 hr of time awake. Measurements were carried out on two occasions separated by 10 weeks. Five participants participated in both measurement weeks. The number of saccades decreased during sustained wakefulness. The data correlated with the three-process model of alertness; performance differed between participants but was stable within individual participants. A mathematically monotonous relation between performance in the saccade task and time awake was seen after removing the circadian rhythm component from measured eye movement data. The results imply that saccades measured with EOG can be used as a time-awake metric outside the laboratory.

Impact of the measurement conditions and compression paddle on mammography dosimeter response.

The effect of mammography measurement conditions was investigated to evaluate their impact on measurement uncertainties in clinical practice. The most prominent physical X-ray beam quantities i.e., - air kerma, half-value layer, and X-ray tube voltage - were examined by measuring the response of two ionization chambers and six X-ray multimeters (XMMs) of different models. Measurements were performed using several anode/filter combinations and both with and without the compression paddle in the X-ray beam. Maximum differences of higher than 6 % were found for all quantities when the dosimeter displayed value was compared with the reference value or the variation within the clinical anode/filter combinations Mo/Mo and Mo/Rh were considered. The study showed that the calibration procedure with the W/Al anode/filter combination was reliable only for ionization chambers, and the response of XMMs varies in such a way that the calibration coefficient cannot be predicted between various measurement conditions used in calibration and clinical practices. XMM calibrations are typically performed without a compression paddle in the beam, and the response of the XMM changes when radiation quality is slightly altered. If XMM specific data is not available, based on this study, an additional uncertainty of 2 % (k = 1) could be used as a typical estimate, at least for air kerma measurements. XMMs should be used for clinical measurements in mammography only with correct settings. If the correct settings are not available, the XMMs should not be used or used only with extreme caution.

Modeling balance control during sustained waking allows posturographic sleepiness testing.

We develop a method to quantify sleepiness. Sleepiness is a major risk factor in traffic and occupational accidents, but lack of convenient tests precludes monitoring impending sleepiness. Posturographic balance testing could address this need because sleepiness increases postural sway. It is, however, unclear how sleepiness influences balance control. Our results, for 12 subjects, show that balance control is more susceptible to increasing time awake (TA) compared to neuromuscular processes. This conclusion is reached since during sustained waking the control process slows down by 3.4% per hour of increased TA. This slowdown accounts for 65% of the variance in diurnal balance. We quantified balance control by modeling the body as an inverted pendulum and by expressing the control as the critical time interval for open-loop control (Deltat(c)) of the center-of-mass movements of this pendulum. To estimate the subjects' TA, we regressed the Deltat(c) scores recorded during sustained waking against increasing TA, and equated separate Deltat(c) test scores with the diurnal Deltat(c) scores. We estimated TA with 68% positive predictive value. The results encourage implementing balance modeling into a device that performs clinical or industrial balance testing because the model-based Deltat(c) score responded to increasing TA.

Nintendo Wii Fit-Based Sleepiness Testing is Not Impaired by Contagious Sleepiness.

Sleep deprivation may cause accidents, and it has deteriorating effects on health. A measurement of postural steadiness by a portable and affordable Nintendo Wii Fit balance board can be used to quantify a person's alertness. At work, people are under the influence of their environment-often other people-that may affect their alertness. This work investigates whether sleep deprivation among people is "contagious," as quantified by sway measures. We measured 21 volunteers' postural steadiness while alert and sleep deprived. During the measurements, a screen placed in front of the participants showed a footage of either alert or sleep-deprived faces. We found a significant difference between the day time and night time steadiness, but found no effect resulting from watching footage of sleep-deprived people. This finding shows that a posturographic sleepiness tester quantifies physiological sleep deprivation, and is insensitive to the influence of social factors.

Nintendo® Wii Fit based sleepiness tester detects impairment of postural steadiness due to 24 h of wakefulness.

A field-usable sleepiness tester could reduce sleepiness related accidents. 15 subjects' postural steadiness was measured with a Nintendo(®) Wii Fit balance board every hour for 24 h. Body sway was quantified with complexity index, CI, and the correlation between CI and alertness predicted by a three-process model of sleepiness was calculated. The CI group average was 8.9 ± 1.3 for alert and 7.9 ± 1.4 for sleep deprived subjects (p < 0.001, ρ = 0.94). The Wii Fit board detects the impairment of postural steadiness. This may allow large scale sleepiness testing outside the laboratory setting.

Posturographic sleepiness monitoring.

Although reduced sleep often underlies traffic and occupational accidents, convenient sleepiness testing is lacking. We show that posturographic balance testing addresses this issue, because balance testing predicts hours of wakefulness, which could facilitate sleepiness testing. Here, we equate balance scores from separate trials, blinded to the experimenter, with those recorded as a function of known and increasing time awake (i.e. during sustained wakefulness); we show, that the time awake in separate trials is posturographically measurable: positive predictive value 69%, sensitivity 56%, and specificity 96%. These results encourage further work developing posturographic sleepiness monitoring.