Place identity, autobiographical memory and life path trajectories: The development of a place-time-identity model.

The ability to remember, recognize and reconstruct places is a key component of episodic autobiographical memory. In this respect, place forms an essential basis for the unfolding of experiences in memory and imagination. The autobiographical memory is seen to contribute to a sense of self and place identity. The aim of this study was to concertedly analyze paintings, autobiographical narrations and places of birth and life of clients under treatment at a psychiatric clinic in Switzerland who were manifesting psychiatric disorders, e.g. depression, anxiety disorders, bipolar disorder, personality disorder, substance dependence, and dementia. Each client exhibited distinctive attitudes and approaches towards life characterized by unique personal mental constructs for living in given places of time episodes that worked towards shaping the development of their identities as well as the development of their health. For these clients, place and time function together to leave a mark, a trajectory, that can hinder or help the resolution of a psychiatric condition. Based on six representative cases, we illustrate how each painting, each biographical narration and each interview reveals deeper structures of individual perception, emotions, feelings, coping strategies, and capacities to reflect and identify with place-time trajectories. Based on this analysis, a place-time-identity model has been developed, which emphasizes the importance of narration, the structure of personality, and emotional experiences in the development of the 'relay station' of episodic autobiographical memory, self and autonoetic consciousness: these three elements are not only connected through their embeddedness in time, but also through their embeddedness in place. In this context, place provides an external fundus of memory, capable of supporting humans in healthy recollection and remembering. The process of placing appears to contribute to the creation of self-esteem and identity. This psycho-geographical place-life-time approach is contrasted to phenomenological place-space-time theories of Husserl, Heidegger, Bachelard, and Sloterdijk.

Dissemination of multi-resistant Gram-negative bacteria into German wastewater and surface waters.

Carbapenem antibiotics constitute the mainstay therapy of nosocomial infections with extended spectrum beta-lactamase producing Gram-negative bacteria; however, resistance against these compounds is increasing. This study was designed to demonstrate that carbapenemase-producing bacteria are disseminated from hospitals into the environment. To this end, resistant bacteria were isolated from a clinical/urban and from a rural catchment system in Germany in 2016/17. The study followed the dissemination of resistant bacteria from the wastewater through the wastewater treatment plant (WWTP) into the receiving surface waters. The bacteria were cultivated on selective agar and characterized by antibiotic testing, real-time PCR targeting carbapenemase genes and typing. Bacteria with resistance to third generation cephalosporins were isolated from all sample sites. 134 isolates harboring carbapenemase genes encoding VIM, NDM and OXA-48 and 26 XDR (extensively drug-resistant) strains with susceptibility to only one or two antibiotics were isolated from the clinical/urban system. The rural system yielded eight carbapenemase producers and no XDR strains. In conclusion, clinical wastewaters were charged with a high proportion of multidrug resistant bacteria. Although most of these bacteria were eliminated during wastewater treatment, dissemination into surface waters is possible as single carbapenemase producers were still present in the effluent of the WWTP.

An LC-MS/MS based candidate reference method for the quantification of carbamazepine in human serum.

A validated LC-MS/MS-based candidate reference measurement procedure for the quantification of carbamazepine is presented in order to be used for standardization and harmonization of routine assays applied for therapeutic drug monitoring. Sample preparation was based on protein precipitation using acetonitrile followed by sample dilution. Since the previously listed certified reference material (CRM) SRM 1599 (anticonvulsant drug level assay standard) is no longer available, an ISO certified calibration material was used in this assay. As internal standards deuterated analyte congeners were applied. The method allows the measurement of carbamazepine, carbamazepine-10,11-epoxide and 10-hydroxy-10,11-dihydrocarbamazepine in the concentration range of 0.1 to 22.0µg/ml with LODs and LOQs of <0.1µg/ml and 0.1µg/ml, respectively. Comparative measurement of 105 native patient samples using the here presented method showed a good agreement between two independent laboratories with a mean bias of 0.6%.

Applying QMRA and DALY to assess health risks from river bathing.

To estimate the health impact of bathing in urban river waters a two-step risk assessment was conducted using the example of the Ruhr River in North-Rhine Westphalia (Germany). The risk of acquiring gastrointestinal illness (GI) due to bathing in the Ruhr River was the focus of this analysis. Referring to the WHO guidelines for safe recreational water environments, risk was defined as the probability of occurrence x severity of harm. Thus, the probability of acquiring GI by bathing in the Ruhr River has been calculated by means of the quantitative microbial risk assessment (QMRA) method. Additionally to this, harm was operationalized by using the DALY metric, quantifying the impact of disability for public health. The calculation of the DALYs based on the QMRA results, disease and lethality data of the population, duration of diseases, disability weights and a demographic profile of a regionally determined potential bathing population. DALYs were calculated for norovirus gastroenteritis, rotavirus gastroenteritis, cryptosporidiosis and giardiasis. The calculated DALYs were set into relation to other risks of daily life. Furthermore the effect of age weighting and time discounting for this site-specific population was considered. The viral load caused the main part of the environmental burden of disease by bathing in the river. The calculated DALYs are significantly lower than DALYs for all cause GI in Germany, which reach 1.19 DALY/1000, or DALYs accepted for an official EG designated bathing water (2.579 DALYs/1000 persons) but on a comparable level with the DALY for drowning (0.26 DALY/1000 Persons). The DALY concept provides a complementary tool to the QMRA for evaluating and comparing health risks arising from a specific environment for a specific population and behaviour and for comparing with other health risks of daily life.

Subduction of the oceanic Hikurangi Plateau and its impact on the Kermadec arc.

Large igneous province subduction is a rare process on Earth. A modern example is the subduction of the oceanic Hikurangi Plateau beneath the southern Kermadec arc, offshore New Zealand. This segment of the arc has the largest total lava volume erupted and the highest volcano density of the entire Kermadec arc. Here we show that Kermadec arc lavas south of ~32°S have elevated Pb and Sr and low Nd isotope ratios, which argues, together with increasing seafloor depth, forearc retreat and crustal thinning, for initial Hikurangi Plateau-Kermadec arc collision ~250 km north of its present position. The combined data set indicates that a much larger portion of the Hikurangi Plateau (the missing Ontong Java Nui piece) than previously believed has already been subducted. Oblique plate convergence caused southward migration of the thickened and buoyant oceanic plateau crust, creating a buoyant 'Hikurangi' mélange beneath the Moho that interacts with ascending arc melts.

Louisville seamount subduction and its implication on mantle flow beneath the central Tonga-Kermadec arc.

Subduction of intraplate seamounts beneath a geochemically depleted mantle wedge provides a seldom opportunity to trace element recycling and mantle flow in subduction zones. Here we present trace element and Sr, Nd and Pb isotopic compositions of lavas from the central Tonga-Kermadec arc, west of the contemporary Louisville-Tonga trench intersection, to provide new insights into the effects of Louisville seamount subduction. Elevated (206)Pb/(204)Pb, (208)Pb/(204)Pb, (86)Sr/(87)Sr in lavas from the central Tonga-Kermadec arc front are consistent with localized input of subducted alkaline Louisville material (lavas and volcaniclastics) into sub-arc partial melts. Furthermore, absolute Pacific Plate motion models indicate an anticlockwise rotation in the subducted Louisville seamount chain that, combined with estimates of the timing of fluid release from the subducting slab, suggests primarily trench-normal mantle flow beneath the central Tonga-Kermadec arc system.