Copper and zinc concentrations, and superoxide dismutase activities in malignant and nonmalignant tissues of female reproductive organs.

The copper and zinc concentrations in 44 malignant and 48 nonmalignant women tissue samples of reproductive organs in women were measured. In malignant samples, the mean copper concentrations were 110%, 76%, and 38% higher for cervix, endometrium and ovary than the nonmalignant ones. The zinc concentrations in the analysed malignant tissues were lower than that in the corresponding nonmalignant tissues. The results of superoxide dismutase activities determinations demonstrate a considerable lowering of the enzymatic capacities to remove free oxygen radical in malignant tissues. A hypothesis for possible mechanism involving elevated copper concentrations, and decreased zinc concentrations, which may be responsible for malignant processes, are presented.

[Bile acids from blood serum of women during normal pregnancy]. / Kwasy zólciowe w surowicy krwi kobiet w normalnej ciazy.

Bile acid concentrations were measured enzymatically in study of women through normal pregnancy. Mean serum bile acid levels increased significantly, from 5.3 (SD 0.9) mumol/l at 16 weeks to 7.2 (SD 1.0) mumol/l at term. Serum bile acid concentrations were greater of older women, than of younger women.

[Decreased activity of oxidoreductases in erythrocytes and blood platelets from venous and umbilical blood of women with pregnancy-induced hypertension]. / Zmniejszenie aktywnosci enzymów przeciwoksydacyjnych w erytrocytach i plytkach krwi zylnej i pepowinowej kobiet z nadcisnieniem indukowanym ciaza.

Thirty two pregnancies with pregnancy-induced hypertension (PIH) and twenty seven control normal pregnancies were analysed with regard to maternal and fetal blood enzymatic antioxidants. In PIH maternal erythrocyte, platelet and serum blood and in umbilical cord blood levels of lipid peroxides were higher than in normal pregnancy. Also the activities of platelet and erythrocyte superoxide dismutase and glutathione peroxidase were lower in PIH women. The concentration of lipid peroxides was higher, and the activity of glutathione peroxidase were lower in umbilical cord elements of women with PIH, than corresponding values of women with normal pregnancy. We suggest that disturbances in antioxidant enzymatic system are involved in the pathogenesis of maternal PIH, and it may also have effects on the function of antioxidant status of the fetus.

[Increased cholesterol in red cell membranes in women with pregnancy induced hypertension]. / Wzrost ilosci cholesterolu w blonach erytrocytów u kobiet z nadcisnieniem indukowanym ciaza.

The group of 24 women in the course of the first pregnancy complicated by hypertension was investigated. The higher amount of cholesterol in red cells membrane was found comparing to healthy pregnant and nonpregnant women. Cholesterol amount in red cells membranes is related to LDL cholesterolemia.

[Retinoids--drugs with a strong teratogenic side effect]. / Retinoidy--leki o ubocznym silnym dzialaniu teratogennym.

The derivatives of the vitamin A--retinoids, are very precious drugs used in dermatology. Forever, they are very strong teratogens and their applications in case of women before the menopause may cause serious deformations of the fetus. So we presented the recommendations so as to applications of the retinoids in such women.

[Effect of past abortions and the sequence of gestations on the course of the next pregnancy and labor as well as the state-at-delivery, maturity, dystrophia and mortality rate of the newborn infants]. / Wplyw przebytych przerwan ciazy i kolejnosci ciazy na przebieg nastepnej ciazy i porodu oraz stan, dojrzalosc, dystrofie i umieralnosc noworodków.

PIP: Legal abortions have reduced the number of miscarriages by 20%, and of abandoned children by 56%; but at the same time, can be hazardous to the mother both initially (loss of blood, punctured uterus, damaged cervix) and later (infections in the reproductive system, infertility, extrauterine pregnancy, psychological disorders). From 1968 to 1975, 12,795 mothers and their newborns were studied: group 1 (24.8%), were mothers who have had abortions prior to 1st delivery; group 2 (42.3%), mothers having a first delivery with no previous miscarriages or abortions; and group 3 (32.9%), mothers of 2 or more children who had abortions afterwards. Abortion prior to first delivery increased the number of complications (54.4%) during pregnancy (liver and kidney problems, bacterial and viral infections), and during delivery (dirty amniotic fluid, bag of waters ruptured prematurely, pathology of the placenta and membranes, pathology of the umbilical cord). 10% of the deliveries where the mother had a previous history of abortion required medical intervention. Intrauterine dystrophy had occurred in 17% cases and the incidence of premature births was greater, 16%. 29.2% of the infants were in poor condition at delivery according to the Apgar scale (under 4 points) and 42.4% manifested disturbances in environment adaptability. The neonatal mortality rate 6.6% was twice that of the infants from the other 2 groups. The authors conclude that abortions are a threat to the health of mothers and during subsequent pregnancies, endanger the fetus and the newborn. Abortion cannot be regarded as a means of family planning. (Summaries in RUS, ENG).^ieng

[Changes of lipid and lipoprotein levels in serum of women in the early postoperative period after surgical castration]. / Zmiany stezen lipidów i lipoprotein w surowicy krwi kobiet we wczesnym okresie po kastracji chirurgicznej.

Concentration of lipids and lipoproteins was estimated in the serum of 26 women after surgical menopause. Different range of changes in concentration of lipoproteins was noticed. First, decreasing levels of concentration of lipo- and lipoprotein fractions was confirmed, and then, their increasing levels in the end of the research period.

[Unsaturated fatty acids of trans isomers in plasma of pregnant women and birth weight]. / Nienasycone kwasy tluszczowe izomerii trans w osoczu krwi kobiet ciezarnych a masa urodzeniowa noworodka.

Trans unsaturated fatty acid originated from synthetic technology. Human consumption of trans isomers of unsaturated fatty acids increased markedly. The induction of growth failure was observed in animals when trans fatty acids were supplied. We studied whether or not there are indications of untoward effects of trans fatty acids in premature infants. Trans fatty acids were in higher concentrations in plasma of 23 women in pre-term delivery compared with 21 women delivering in normal term. Trans fatty acids in plasma were also inversely correlated to birth weight and with gestational age. These data indicate a impairment of intrauterine growth by trans isomer of unsaturated fatty acids.

[Concentration of selenium and vitamin E in the serum of women with malignant genital neoplasms and their family members]. / Stezenie selenu i witaminy E w surowicy krwi kobiet z nowotworami zlosliwymi narzadów plciowych oraz u czlonków ich rodzin.

Lower concentrations of selenium and vitamin E were found in the serum of 50 women with malignant neoplasms of the genitals as compared with the concentrations in 55 healthy women family members of the patients living with them in common households. The degree of concentration decrease of these substances in the serum depended on the location of the tumour, and in cases of cervical neoplasms was 28% for selenium and 12% for vitamin E of the values in controls while in cases of ovarian neoplasms it was 34% and 37% respectively and in endometrial tumours it was 40% and 23% respectively. The third studied group comprised 36 healthy subjects not belonging to the families of the patients. The highest concentrations of selenium and vitamin E were found in the serum in the third group of women. The results suggest that various family factors not analysed in this study affect the concentrations of selenium and vitamin E in the serum of women with malignant neoplasms of genitals and in their family members.

Placental phospholipase A2 activities in pre-eclampsia.

Phospholipase A2 activity was significantly increased in placental homogenates from 22 patients with preeclampsia in comparison to placental homogenates from women with uncomplicated pregnancy. Such an abnormality may be responsible for a altered release of free arachidonic acid, thus playing a major role in the pathogenesis of this syndrome.

[Pregnancy induced changes in lipid-lipoprotein serum profile in women and newborn birth weight]. / Zmieniony ciaza profil lipidowo-lipoproteinowy surowicky kobiet a urodzeniowa masa noworodka.

The pregnancy is associated with hyperlipoproteinemia including an increased level of total cholesterol, LDL-cholesterol, HDL2 and HDL3-cholesterol and triglycerides. The mechanism of pregnancy associated hyperlipoproteinemia remain unclear. The aim of the study was to estimate the relationship between the newborn body mass at delivery and changed by pregnancy lipid-lipoprotein blood profile in women. Studies were carried out in the cases of 67 women. Blood samples were studied at 25 week of pregnancy, during the labor, and at 5th day after delivery. No influence of the pregnancy-changed lipid-lipoprotein pattern of the mothers on the body mass of newborns was found in any of the investigated period.

[The type of material primary hyperlipoproteinemia and newborn birth weight]. / Typ hiperlipoproteinemii pierwotnej matki a masa urodzeniowa noworodka.

Twenty four cases of hyperlipoproteinemia were reported in the investigated group of 67 mother, which delivered behind 38 and 41 week of pregnancy newborns above 2500 g body mass. They were characterized as IIa and IV types according to the WHO classification. Fifteen mothers had HLP of IV type. The average delivery body mass of newborns of these mothers was 3550 g. Nine mothers had HLP of IIa type and these mothers delivered the lightest newborns, average delivery body mass was 3117 g while the average of with normolipidemia mothers was 3238 g. The chi 2 test indicated that the delivery body mass of the newborns is related to the type of hyperlipoproteinemia of mother (p < 0.05).

[Lipid-lipoprotein serum profile of the newborn and its birth weight]. / Profil lipidowo-lipoproteinowy surowicy noworodka a jego masa urodzeniowa.

The sixty-seven newborns were investigated. The umbilical cord blood samples were used to determine following indices: total cholesterol, LDL, HDL2, HDL3-cholesterol, total phospholipids, LDL, HDL-phospholipids, triglycerides and apolipoprotein B. The chi 2 test indicated correlations between increased levels of triglycerides, phospholipids LDL and cholesterol HDL2 and decreased level of cholesterol LDL in the group of newborns with the lowest delivery body mass.

[Mineral components of the human placenta, birth weight and infant head circumference]. / Sklad mineralny lozyska ludzkiego a masa urodzeniowa i obwód glówki noworodka.

Levels of mineral elements (F, Na, Mg, Al, S, Cl, K, Ca, V, Cr, Mn, Fe, Co, Cu, Zn, Se, Br, Rb, Mo, Cd, J, Ba, Hg and Pb), the role of which is well known and documented, were studied in 365 placentas. The significant negative correlations were ascertained between the content of Pb, Cd, F, Hg and the birth weight; the positive correlations were ascertained between some minerals (Mg, Ca, Co, Cu, Zn, Se) that are indispensable for the proper organism functioning and the fetus development.

[Actuality of hysterosalpingography in women with infertility]. / Aktualnoslc histerosalpingografii w nieplodnosci u kobiet.

In 283 women with infertility HSG results have been analyzed. Fallopian tubes have been found to be patent in 196 subjects, whereas in 87 subjects distal or proximal unilateral or bilateral impatency has been observed. In 28 subjects with impatent fallopian tubes uterus malformations were found. 72 women with impatent oviducts were treated by laparoscopy alongside with oviduct chromotubation. On basis of clinical findings as well as cases reported in literature, HSG relevancy in infertility diagnostics has been proved.

[Changes of pituitary hormone concentration during vasomotor disorders, in blood serum of women during the early phase after surgical castration]. / Zmiany stezen hormonów przysadkowych w czasie zaburzen naczynioruchowych w surowicy krwi kobiet we wczesnym okresie po kastracji chirurgicznej.

The behaviour of the concentration of the selected pituitary hormones during hot flushes at women after a surgical castration was evaluated. The inquiry concerned 42 women 46.7 +/- 3.4 years old, with a regular menstruation till the hysterectomy and the adnexectomy due to sexual organs diseases. The inquiry contained a determination, by means of radioimmunological methods, of the concentration of the hormones: LH, FSH, PRL, HGH, TSH in the blood serum taken at women 48 hours before the operation, on the 8th day after the intervention and 5 min after the hot flushes apparition. At the same time, the finger skin temperature and the pulse rate was taken. The rise in the finger skin temperature by 1.2 degrees C and the mean rise in the pulse rate by 11.3 beats/min during hot flushes were noticed. An important increase of the LH and HGH concentration during hot flushes was also observed.

[Usefulness of determining tumor markers CEA, CA125 and CA72-4 in blood serum of patients with ovarian carcinoma]. / Przydatnosc oznaczen markerów nowotworowych CEA, CA125 i CA72-4 w surowicy krwi chorych na raka jajnika.

Serum levels of 3 markers: CEA, CA125 and CA72-4 have been determined in 58 patients aged from 15-60 years with histologically diagnosed ovarian cancer. Serum CEA was determined by radioimmunoassay using kits POLATOM (Poland), CA72-4 was determined using kits CIS BIOINTERNATIONAL (France) and CA125 was determined by enzyme immunoassay using kits Hoffmann-la-Roche (Wien-Austria). We have observed the growth of sensitivity and specificity of serum levels: CA125 and CA72-4 if we have referred to the simultaneous elevation of CA125 and CA72-4 markers. We have observed that CA125 and CA72-4 elevated levels were proceeded clinical recurrent of the disease from 2 to 6 months.

[Zinc levels in semen of men from childless marriages]. / Stezenie cynku w nasieniu u mezczyzn z malzenstw bezdzietnych.

Zinc concentration in human semen was studied on the material of 106 male patients aged 20-35, from childless marriages. Full microscopic examination was performed including number of spermatozoons, mobility, fluxing time, pH, morphological composition, number of leucocytes. Zinc level was measured using spectrophotometric analysis. Trial of relation estimation between zinc concentration and number of live spermatozoons and pH of the semen was taken out. Any significant differences between zinc concentration in the semen from normospermic and oligospermic males were found. There was proved, that semen pH increase was correlated to zinc concentration decrement in the semen fluid.

[Zinc concentration in human semen of men from childless marriages]. / Stezenie cynku w nasieniu u mezczyzn z malzenstw bezdzietnych.

Zinc concentration in human semen was studied on the material of 106 male patients aged 20-35, from childless marriages. Full microscopic examination was performed including number of spermatozoa mobility, flux time, pH, morphological composition, number of leucocytes. Zinc level was measured using spectrophotometric analysis. Trial of relation estimation between zinc concentration and number of live spermatozoa and pH of the semen was taken out. Any significant differences between zinc concentration in the semen from normospermic and oligospermic males were found. There was proved, that semen pH increase was correlated to zinc concentration decrement in the semen fluid.

[Pregnancy outcome in women after ovulation induction]. / Przebieg ciazy po indukcji owulacji.

UNLABELLED: The study was performed in 116 pregnant women after ovulation induction in 1995-1999. The pregnancy outcome was analysed. In 92 of 116 women (79.3%) successful outcome ("home taken baby") was observed. In 56 of them (60.9%) spontaneous delivery took place, in 4 (4.3%) women birth with vacuum extractor was performed, and in 32 (34.8%) caesarean section was done. In 24 of 116 women (20.7%) the pregnancy outcome was unsuccessful. In 12 of them (10.3%) missed abortion, and in 7 women (6%) spontaneous abortion was observed. 2 patients (1.7%) had caesarean section (in 24th and in 29th week of gestation) because of preeclampsia. One birth (0.9%) was premature because of the cervical incompetency. CONCLUSIONS: The pregnancy outcome in women after ovulation induction is frequently (20.7%) unsuccessful. The delivery in patients after ovulation induction frequently (34.8%) takes place with caesarean section.