Detalhe da pesquisa
1.
Discovery and optimization of dihydropteridone derivatives as novel PLK1 and BRD4 dual inhibitor for the treatment of cancer.
Bioorg Med Chem
; 101: 117609, 2024 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38364599
2.
Design, synthesis, and biological evaluation of 2,4-diaminopyrimidine derivatives as potent Hematopoietic Progenitor Kinase 1 (HPK1) inhibitors.
Bioorg Chem
; 148: 107454, 2024 May 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38795581
3.
2-Aminopyrimidine derivatives as selective dual inhibitors of JAK2 and FLT3 for the treatment of acute myeloid leukemia.
Bioorg Chem
; 134: 106442, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36878064
4.
A Dual Coverage Monitoring of the Bile Acids Profile in the Liver-Gut Axis throughout the Whole Inflammation-Cancer Transformation Progressive: Reveal Hepatocellular Carcinoma Pathogenesis.
Int J Mol Sci
; 24(5)2023 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36901689
5.
Synthesis and biological evaluation of new series of benzamide derivatives containing urea moiety as sEH inhibitors.
Bioorg Med Chem Lett
; 70: 128805, 2022 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35598794
6.
Discovery of benzamide derivatives containing urea moiety as soluble epoxide hydrolase inhibitors.
Bioorg Chem
; 127: 105898, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35792317
7.
A Diuretic Response is Associated with the Early Prognosis of Patients Undergoing Repeat Tricuspid Valve Surgery Due to Severe Tricuspid Regurgitation After Left-Sided Valvular Surgery.
Heart Surg Forum
; 25(4): E574-E578, 2022 Jul 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-36052905
8.
Evaluating Lymph Node Stiffness to Differentiate Bacterial Cervical Lymphadenitis and Lymph Node-First Presentation of Kawasaki Disease by Shear Wave Elastography.
J Ultrasound Med
; 40(7): 1371-1380, 2021 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-33006783
9.
An Integrated Mutually Oriented "Chemical Profiling-Pharmaceutical Effect" Strategy for Screening Discriminating Markers of Underlying Hepatoprotective Effects to Distinguish Garden-Cultivated from Mountain-Cultivated Ginseng.
Molecules
; 26(18)2021 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34576927
10.
Green and enhanced extraction of coumarins from Cortex Fraxini by ultrasound-assisted deep eutectic solvent extraction.
J Sep Sci
; 43(17): 3441-3448, 2020 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-32579249
11.
Deep learning Radiomics of shear wave elastography significantly improved diagnostic performance for assessing liver fibrosis in chronic hepatitis B: a prospective multicentre study.
Gut
; 68(4): 729-741, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29730602
12.
Liver Fibrosis with Two-dimensional US Shear-Wave Elastography in Participants with Chronic Hepatitis B: A Prospective Multicenter Study.
Radiology
; 289(2): 407-415, 2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30040048
13.
Outcomes and Risk Factors Associated with Pericardiectomy in Patients with Constrictive Pericarditis: A Retrospective Study from China.
Ann Thorac Cardiovasc Surg
; 30(1)2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38811208
14.
Novel biaryloxazolidinone derivatives with broad-spectrum antibacterial activity, favorable drug-like profiles and in vivo efficacy against linezolid-resistant Staphylococcusaureus.
Eur J Med Chem
; 273: 116493, 2024 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38761790
15.
Left atrial subclinical dysfunction in children with Kawasaki disease: a two-dimensional speckle-tracking echocardiography study.
Minerva Pediatr (Torino)
; 75(4): 567-575, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31144493
16.
Accurate determination for lipidomics based on LC-tandem-MS parameters modeling, prediction, and database: Monitoring the progression of hepatocellular carcinoma.
J Pharm Biomed Anal
; 223: 115126, 2023 Jan 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36327578
17.
Discovery of novel 7,7-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidines as ATR inhibitors based on structure-based drug design.
Eur J Med Chem
; 246: 114945, 2023 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36462444
18.
Design, synthesis, and biological evaluation of novel dihydropteridone derivatives possessing oxadiazoles moiety as potent inhibitors of PLK1.
Eur J Med Chem
; 251: 115242, 2023 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36889251
19.
PM2.5-Induced Programmed Myocardial Cell Death via mPTP Opening Results in Deteriorated Cardiac Function in HFpEF Mice.
Cardiovasc Toxicol
; 22(8): 746-762, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35593990
20.
A convenient and efficient 4-(diethylamino)-butylamine-labeled polarity-response-homodispersed strategy for absolute quantification of carboxyl submetabolome: Monitoring the whole progressive course of hepatocellular carcinoma.
J Chromatogr A
; 1683: 463504, 2022 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36183682