Detalhe da pesquisa
1.
Harvesting and amplifying gene cassettes confers cross-resistance to critically important antibiotics.
PLoS Pathog
; 20(6): e1012235, 2024 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-38843111
2.
Tautomer-Specific Deacylation and Ω-Loop Flexibility Explain the Carbapenem-Hydrolyzing Broad-Spectrum Activity of the KPC-2 ß-Lactamase.
J Am Chem Soc
; 145(13): 7166-7180, 2023 04 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36972204
3.
Natural variants modify Klebsiella pneumoniae carbapenemase (KPC) acyl-enzyme conformational dynamics to extend antibiotic resistance.
J Biol Chem
; 296: 100126, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33257320
4.
Molecular Basis of Class A ß-Lactamase Inhibition by Relebactam.
Antimicrob Agents Chemother
; 63(10)2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31383664
5.
Profiling interactions of vaborbactam with metallo-ß-lactamases.
Bioorg Med Chem Lett
; 29(15): 1981-1984, 2019 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31171422
6.
Cross-class metallo-ß-lactamase inhibition by bisthiazolidines reveals multiple binding modes.
Proc Natl Acad Sci U S A
; 113(26): E3745-54, 2016 06 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-27303030
7.
Non-Hydrolytic ß-Lactam Antibiotic Fragmentation by l,d-Transpeptidases and Serine ß-Lactamase Cysteine Variants.
Angew Chem Int Ed Engl
; 58(7): 1990-1994, 2019 02 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30569575
8.
A New Mechanism for ß-Lactamases: Class D Enzymes Degrade 1ß-Methyl Carbapenems through Lactone Formation.
Angew Chem Int Ed Engl
; 57(5): 1282-1285, 2018 01 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29236332
9.
Studies on the Reactions of Biapenem with VIM Metallo ß-Lactamases and the Serine ß-Lactamase KPC-2.
Antibiotics (Basel)
; 11(3)2022 Mar 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-35326858
10.
Penicillanic Acid Sulfones Inactivate the Extended-Spectrum ß-Lactamase CTX-M-15 through Formation of a Serine-Lysine Cross-Link: an Alternative Mechanism of ß-Lactamase Inhibition.
mBio
; 13(3): e0179321, 2022 06 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35612361
11.
Faropenem reacts with serine and metallo-ß-lactamases to give multiple products.
Eur J Med Chem
; 215: 113257, 2021 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33618159
12.
Allosteric communication in class A ß-lactamases occurs via cooperative coupling of loop dynamics.
Elife
; 102021 03 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-33755013
13.
An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography.
Nat Commun
; 12(1): 4461, 2021 07 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34294694
14.
Cyclic boronates as versatile scaffolds for KPC-2 ß-lactamase inhibition.
RSC Med Chem
; 11(4): 491-496, 2020 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33479650
15.
ß-Lactamases and ß-Lactamase Inhibitors in the 21st Century.
J Mol Biol
; 431(18): 3472-3500, 2019 08 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-30959050
16.
Mechanistic Insights into ß-Lactamase-Catalysed Carbapenem Degradation Through Product Characterisation.
Sci Rep
; 9(1): 13608, 2019 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31541180
17.
Exploitation of Antibiotic Resistance as a Novel Drug Target: Development of a ß-Lactamase-Activated Antibacterial Prodrug.
J Med Chem
; 62(9): 4411-4425, 2019 05 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31009558
18.
Insights into the Mechanistic Basis of Plasmid-Mediated Colistin Resistance from Crystal Structures of the Catalytic Domain of MCR-1.
Sci Rep
; 7: 39392, 2017 01 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28059088