1.
Nephrology (Carlton)
; 10(4): 362-7, 2005 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16109083
RESUMO
The podocyte is a highly specialized cell that plays a key role in regulating the glomerular filtration barrier. A number of advances have been made in recent years, linked to the discovery of single-gene defects in hereditary glomerular disease, which highlight the role of this cell in preventing proteinuria. This article reviews the molecular biology of the podocyte, focusing on known genetic abnormalities.