Detalhe da pesquisa
1.
Factor H-Related Protein 1 Drives Disease Susceptibility and Prognosis in C3 Glomerulopathy.
J Am Soc Nephrol
; 33(6): 1137-1153, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35545301
2.
Interaction between Multimeric von Willebrand Factor and Complement: A Fresh Look to the Pathophysiology of Microvascular Thrombosis.
J Immunol
; 199(3): 1021-1040, 2017 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28652401
3.
FHR-1 Binds to C-Reactive Protein and Enhances Rather than Inhibits Complement Activation.
J Immunol
; 199(1): 292-303, 2017 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28533443
4.
Factor H Competitor Generated by Gene Conversion Events Associates with Atypical Hemolytic Uremic Syndrome.
J Am Soc Nephrol
; 29(1): 240-249, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28993505
5.
Complete functional characterization of disease-associated genetic variants in the complement factor H gene.
Kidney Int
; 93(2): 470-481, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28941939
6.
Functional and structural characterization of four mouse monoclonal antibodies to complement C3 with potential therapeutic and diagnostic applications.
Eur J Immunol
; 47(3): 504-515, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28083930
7.
Factor H-related proteins determine complement-activating surfaces.
Trends Immunol
; 36(6): 374-84, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25979655
8.
Elevated factor H-related protein 1 and factor H pathogenic variants decrease complement regulation in IgA nephropathy.
Kidney Int
; 92(4): 953-963, 2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28637589
9.
Molecular Basis of Factor H R1210C Association with Ocular and Renal Diseases.
J Am Soc Nephrol
; 27(5): 1305-11, 2016 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26376859
10.
A novel antibody against human factor B that blocks formation of the C3bB proconvertase and inhibits complement activation in disease models.
J Immunol
; 193(11): 5567-75, 2014 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25355917
11.
Structural basis for the stabilization of the complement alternative pathway C3 convertase by properdin.
Proc Natl Acad Sci U S A
; 110(33): 13504-9, 2013 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23901101
12.
A novel atypical hemolytic uremic syndrome-associated hybrid CFHR1/CFH gene encoding a fusion protein that antagonizes factor H-dependent complement regulation.
J Am Soc Nephrol
; 26(1): 209-19, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24904082
13.
Genetics of atypical hemolytic uremic syndrome (aHUS).
Semin Thromb Hemost
; 40(4): 422-30, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24799305
14.
Atypical hemolytic uremic syndrome-associated variants and autoantibodies impair binding of factor h and factor h-related protein 1 to pentraxin 3.
J Immunol
; 189(4): 1858-67, 2012 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22786770
15.
Complement factor H variants I890 and L1007 while commonly associated with atypical hemolytic uremic syndrome are polymorphisms with no functional significance.
Kidney Int
; 81(1): 56-63, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21881555
16.
3D structure of the C3bB complex provides insights into the activation and regulation of the complement alternative pathway convertase.
Proc Natl Acad Sci U S A
; 106(3): 882-7, 2009 Jan 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-19136636
17.
Functional basis of protection against age-related macular degeneration conferred by a common polymorphism in complement factor B.
Proc Natl Acad Sci U S A
; 106(11): 4366-71, 2009 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-19255449
18.
The disease-protective complement factor H allotypic variant Ile62 shows increased binding affinity for C3b and enhanced cofactor activity.
Hum Mol Genet
; 18(18): 3452-61, 2009 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19549636
19.
Coexistence of closed and open conformations of complement factor B in the alternative pathway C3bB(Mg2+) proconvertase.
J Immunol
; 183(11): 7347-51, 2009 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19890040
20.
Activation of the Unfolded Protein Response (UPR) Is Associated with Cholangiocellular Injury, Fibrosis and Carcinogenesis in an Experimental Model of Fibropolycystic Liver Disease.
Cancers (Basel)
; 14(1)2021 Dec 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35008241