Detalhe da pesquisa
1.
Quantitative Contribution of Six Major Transporters to the Hepatic Uptake of Drugs: "SLC-Phenotyping" Using Primary Human Hepatocytes.
J Pharmacol Exp Ther
; 370(1): 72-83, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30975793
2.
In Vitro-In Vivo Extrapolation of OATP1B-Mediated Drug-Drug Interactions in Cynomolgus Monkey.
J Pharmacol Exp Ther
; 365(3): 688-699, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29643253
3.
A Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 2: Prospectively Predicting Systemic and Liver Exposure in Healthy Subjects.
Drug Metab Dispos
; 46(4): 357-366, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29330219
4.
Estimation of Circulating Drug Metabolite Exposure in Human Using In Vitro Data and Physiologically Based Pharmacokinetic Modeling: Example of a High Metabolite/Parent Drug Ratio.
Drug Metab Dispos
; 46(2): 89-99, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29150544
5.
Simultaneous Assessment of Transporter-Mediated Drug-Drug Interactions Using a Probe Drug Cocktail in Cynomolgus Monkey.
Drug Metab Dispos
; 46(8): 1179-1189, 2018 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-29880631
6.
A Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 1: Translating Systemic Plasma Concentration to Liver Exposure in Healthy Subjects.
Drug Metab Dispos
; 46(4): 346-356, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29330218
7.
Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro-In Vivo Scaling of Hepatic Uptake Clearance.
Drug Metab Dispos
; 46(7): 989-1000, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29720472
8.
Deuterium isotope effects on drug pharmacokinetics. I. System-dependent effects of specific deuteration with aldehyde oxidase cleared drugs.
Drug Metab Dispos
; 40(3): 625-34, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22190693
9.
A novel relay method for determining low-clearance values.
Drug Metab Dispos
; 40(9): 1860-5, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22645091
10.
Tissue distribution and elimination of [14C]apixaban in rats.
Drug Metab Dispos
; 39(2): 256-64, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21071521
11.
Prediction of drug-drug interactions from in vitro induction data: application of the relative induction score approach using cryopreserved human hepatocytes.
Drug Metab Dispos
; 36(9): 1971-4, 2008 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-18519654
12.
Hepatobiliary Clearance Prediction: Species Scaling From Monkey, Dog, and Rat, and In Vitro-In Vivo Extrapolation of Sandwich-Cultured Human Hepatocytes Using 17 Drugs.
J Pharm Sci
; 106(9): 2795-2804, 2017 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28456723
13.
Reliable Rate Measurements for Active and Passive Hepatic Uptake Using Plated Human Hepatocytes.
AAPS J
; 19(3): 787-796, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28188574
14.
Assessment of drug metabolism enzyme and transporter pharmacogenetics in drug discovery and early development: perspectives of the I-PWG.
Pharmacogenomics
; 17(6): 615-31, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-27045656
15.
Erratum to: Reliable Rate Measurements for Active and Passive Hepatic Uptake Using Plated Human Hepatocytes.
AAPS J
; 19(3): 882, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28233243
16.
In vitro cytochrome P450 inhibition data and the prediction of drug-drug interactions: qualitative relationships, quantitative predictions, and the rank-order approach.
Clin Pharmacol Ther
; 78(6): 582-92, 2005 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-16338274
17.
Application of liquid chromatography-accelerator mass spectrometry (LC-AMS) to evaluate the metabolic profiles of a drug candidate in human urine and plasma.
Drug Metab Lett
; 1(3): 226-31, 2007 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-19356047
18.
The utility of in vitro cytochrome P450 inhibition data in the prediction of drug-drug interactions.
J Pharmacol Exp Ther
; 316(1): 336-48, 2006 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-16192315
19.
Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: an in vitro study.
Drug Metab Dispos
; 33(2): 262-70, 2005 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-15547048