Detalhe da pesquisa
1.
Apolipoprotein B synthesis inhibition with mipomersen in heterozygous familial hypercholesterolemia: results of a randomized, double-blind, placebo-controlled trial to assess efficacy and safety as add-on therapy in patients with coronary artery disease.
Circulation
; 126(19): 2283-92, 2012 Nov 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-23060426
2.
Efficacy of apolipoprotein B synthesis inhibition in subjects with mild-to-moderate hyperlipidaemia.
Eur Heart J
; 32(21): 2650-9, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21593041
3.
Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial.
Lancet
; 375(9719): 998-1006, 2010 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-20227758
4.
Effect of apolipoprotein-B synthesis inhibition on liver triglyceride content in patients with familial hypercholesterolemia.
J Lipid Res
; 51(5): 1057-62, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20008831
5.
Lack of pharmacokinetic interaction of mipomersen sodium (ISIS 301012), a 2'-O-methoxyethyl modified antisense oligonucleotide targeting apolipoprotein B-100 messenger RNA, with simvastatin and ezetimibe.
Clin Pharmacokinet
; 48(1): 39-50, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19071883
6.
Effects of fenofibrate and ezetimibe, both as monotherapy and in coadministration, on cholesterol mass within lipoprotein subfractions and low-density lipoprotein peak particle size in patients with mixed hyperlipidemia.
Metabolism
; 57(6): 796-801, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18502262
7.
Effects of ezetimibe/simvastatin on lipoprotein subfractions in patients with primary hypercholesterolemia: an exploratory analysis of archived samples using two commercially available techniques.
Clin Ther
; 29(11): 2419-32, 2007 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-18158082
8.
Inhibition of intestinal cholesterol absorption by ezetimibe in humans.
Circulation
; 106(15): 1943-8, 2002 Oct 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-12370217
9.
A multicenter, randomized, double-blind, placebo-controlled, factorial design study to evaluate the lipid-altering efficacy and safety profile of the ezetimibe/simvastatin tablet compared with ezetimibe and simvastatin monotherapy in patients with primary hypercholesterolemia.
Clin Ther
; 26(11): 1758-73, 2004 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-15639688
10.
Efficacy and safety of mipomersen, an antisense inhibitor of apolipoprotein B, in hypercholesterolemic subjects receiving stable statin therapy.
J Am Coll Cardiol
; 55(15): 1611-8, 2010 Apr 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-20378080
11.
Effect of mipomersen, an apolipoprotein B synthesis inhibitor, on low-density lipoprotein cholesterol in patients with familial hypercholesterolemia.
Am J Cardiol
; 105(10): 1413-9, 2010 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20451687
12.
Cross-species comparison of in vivo PK/PD relationships for second-generation antisense oligonucleotides targeting apolipoprotein B-100.
Biochem Pharmacol
; 77(5): 910-9, 2009 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19056355
13.
Efficacy and safety of ezetimibe/simvastatin versus simvastatin monotherapy in hypercholesterolemic patients with metabolic syndrome.
Metab Syndr Relat Disord
; 5(1): 13-21, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-18370810