Effects of 12 days exposure to simulated microgravity on central circulatory hemodynamics in the rhesus monkey.

Central circulatory hemodynamic responses were measured before and during the initial 9 days of a 12-day 10 degrees head-down tilt (HDT) in 4 flight-sized juvenile rhesus monkeys who were surgically instrumented with a variety of intrathoracic catheters and blood flow sensors to assess the effects of simulated microgravity on central circulatory hemodynamics. Each subject underwent measurements of aortic and left ventricular pressures, and aortic flow before and during HDT as well as during a passive head-up postural test before and after HDT. Heart rate, stroke volume, cardiac output, and left ventricular end-diastolic pressure were measured, and dP/dt and left ventricular elastance was calculated from hemodynamic measurements. The postural test consisted of 5 min of supine baseline control followed by 5 minutes of 90 degrees upright tilt (HUT). Heart rate, stroke volume, cardiac output, and left ventricular end-diastolic pressure showed no consistent alterations during HDT. Left ventricular elastance was reduced in all animals throughout HDT, indicating that cardiac compliance was increased. HDT did not consistently alter left ventricular +dP/dt, indicating no change in cardiac contractility. Heart rate during the post-HDT HUT postural test was elevated compared to pre-HDT while post-HDT cardiac output was decreased by 52% as a result of a 54% reduction in stroke volume throughout HUT. Results from this study using an instrumented rhesus monkey suggest that exposure to microgravity may increase ventricular compliance without alternating cardiac contractility. Our project supported the notion that an invasively-instrumented animal model should be viable for use in spaceflight cardiovascular experiments to assess potential changes in myocardial function and cardiac compliance.

[Influence of vestibular and afferent impulses on the spontaneous activity of interneurons in the spinal cord of cats]. / Vliianie vestibuliarnoi i afferentnoi impul'satsii na spontannuiu aktivnost' promezhutochnykh neironov spinnogo mozga koshki

Responses of the cat spinal interneurons were studied under electrical stimulation of dorsal roots and adequate stimulation of vestibular apparatus. The evoked activity of interneurons in response to electrical stimulation of dorsal roots had different forms. Three types of responses to adequate stimulation of vestibular apparatus were observed. The patterns of convergence of afferent and vestibular impulses on the interneurons are discussed.

[Oxygenation of the frontal cerebral cortex in monkeys during a two-week space flight]. / Kislorodnyi rezhim lobnoi kory golovnogo mozga obezíany v protsesse 2-nedelnogo kosmicheskogo poleta.

In monkeys (Macaca mulatta) during a two-week space flight and in a ground-based control experiment, with semi-closed platinum electrodes, partial oxygen pressure (pO2) was registered in the frontal cerebral cortex. It was shown that during the flight there is a marked increase of pO2 in the frontal cortex, reaching maximal values on days 5-8 (up to 203%) with a subsequent tendency to normalization by day 11. In the control experiment pO2 values in the cortical zone studied did not exceed the baseline level throughout the period of registration. Analysis of the curves of pO2 oscillations in the frequency range from 0.2 to 0.01 Hz in-flight revealed a shift of the oscillation power spectrum in the long-wave direction which was not seen in the control experiment and suggested a decreased rate of tissue metabolism. As a possible explanation for the noted effects of pO2 dynamics during weightlessness, a combination of a decreased metabolic rate in the brain segment under study with a disorder in the mechanism of regulation of local cerebral blood flow is suggested.

[Heart functions in monkeys during a 2-week antiorthostatic hypokinesia]. / Funktsii serdtsa u obez'ian vo vremia dvukhnedel'noi antiortostaticheskoi gipokinezii.

Dynamics of the left heart ventricular muscle contractility and compliance was studied in 4 monkeys in the head down position (antiorthostatic hypokinesia) with the body angle 10 during 2 weeks. Functional tests on a tilt table and under two conditions of centrifuge rotation were performed prior to and after the antiorthostatic hypokinesia. No changes in the left heart ventricular muscle contractility was found. However, the sensitivity level of the baroreflex control decreased. Compliance of the left heart myocardial fibre increased in the first hours and days of the antiorthostatic hypokinesia.