Detalhe da pesquisa
1.
Thrombomodulin induces anti-inflammatory effects by inhibiting the rolling adhesion of leukocytes in vivo.
J Pharmacol Sci
; 143(1): 17-22, 2020 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-32122774
2.
Human soluble thrombomodulin-induced blockade of peripheral HMGB1-dependent allodynia in mice requires both the lectin-like and EGF-like domains.
Biochem Biophys Res Commun
; 495(1): 634-638, 2018 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29146186
3.
The effects of AP521, a novel anxiolytic drug, in three anxiety models and on serotonergic neural transmission in rats.
J Pharmacol Sci
; 127(1): 109-16, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25704026
4.
Role of high-mobility group box 1 and its modulation by thrombomodulin/thrombin axis in neuropathic and inflammatory pain.
Br J Pharmacol
; 178(4): 798-812, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32374414
5.
Thrombomodulin alfa prevents oxaliplatin-induced neuropathic symptoms through activation of thrombin-activatable fibrinolysis inhibitor and protein C without affecting anti-tumor activity.
Eur J Pharmacol
; 880: 173196, 2020 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32416186
6.
Discovery of selective PDE4B inhibitors.
Bioorg Med Chem Lett
; 19(12): 3174-6, 2009 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19447034
7.
[HMGB1 as a target for prevention of chemotherapy-induced peripheral neuropathy].
Nihon Yakurigaku Zasshi
; 154(5): 236-240, 2019.
Artigo
em Japonês
| MEDLINE | ID: mdl-31735750
8.
Role of Thrombin in Soluble Thrombomodulin-Induced Suppression of Peripheral HMGB1-Mediated Allodynia in Mice.
J Neuroimmune Pharmacol
; 13(2): 179-188, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29196860
9.
A method for designing conformationally restricted analogues based on allylic strain: synthesis of a novel class of noncompetitive NMDA receptor antagonists having the acrylamide structure.
J Med Chem
; 46(25): 5326-33, 2003 Dec 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-14640541
10.
Identification of structurally diverse growth hormone secretagogue agonists by virtual screening and structure-activity relationship analysis of 2-formylaminoacetamide derivatives.
J Med Chem
; 47(17): 4286-90, 2004 Aug 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-15294000
11.
Neurochemical and behavioural characterization of milnacipran, a serotonin and noradrenaline reuptake inhibitor in rats.
Psychopharmacology (Berl)
; 162(3): 323-32, 2002 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-12122491
12.
Post-marketing surveillance data of thrombomodulin alfa: sub-analysis in patients with sepsis-induced disseminated intravascular coagulation.
J Intensive Care
; 2(1): 30, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25520842
13.
Synthesis of derivatives of (1S,2R)-1-phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopropanecarboxamide (PPDC) modified at the 1-aromatic moiety as novel NMDA receptor antagonists: the aromatic group is essential for the activity.
Bioorg Med Chem
; 10(12): 3829-48, 2002 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-12413836
14.
Synthesis of (1S,2R)-1-phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopropanecarboxamide (PPDC) derivatives modified at the carbamoyl moiety as a new class of NMDA receptor antagonists.
Bioorg Med Chem
; 10(6): 1777-91, 2002 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-11937336