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PURPOSE: To describe a case of replaced posterior cerebral artery (PCA) in which all branches of the PCA arose from the anterior choroidal artery (AChA) with an early branching temporal artery. METHODS: An 83-year-old man with cerebral infarctions underwent cranial magnetic resonance (MR) imaging and MR angiography using a 3-Tesla scanner. MR angiography was performed using a standard 3-dimensional time-of-flight technique. RESULTS: A large anomalous artery arose from the supraclinoid segment of the right internal carotid artery (ICA) and supplied all branches of the right PCA, mimicking fetal-type PCA. The temporal branch arose from the proximal segment of this artery. In MR angiographic source images, a tiny artery arose from the right ICA proximal to the origin of the anomalous artery, indicating a hypoplastic right posterior communicating artery (PCoA). Thus, we concluded that the anomalous artery was a replaced PCA; all branches of the PCA arose from the AChA. CONCLUSION: We present a case involving a replaced PCA with an early branching temporal artery, as seen on MR angiography. Careful observation of MR angiographic source images is useful for identifying small arteries. To our knowledge, this is the first report of this combined variation in the relevant English-language literature.
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BACKGROUND: Conventionally, patients suffering a massive intraventricular hemorrhage have undergone external ventricular drainage. However, long-term or repeated drainage increases the risk of complications due to infections or shunt dependency. Neuroendoscopic surgery may offer some advantages over more conventional procedures. METHODS: Thirteen patients suffering intraventricular hematoma associated with intracerebral hemorrhage, treated in our hospital between April 2011 and March 2014, were reviewed retrospectively. Casting hematomas in the ventricles were manually aspirated using a flexible endoscope. The timing of the operation, period of post-endoscopic ventricular drainage, additional internal shunt surgery, 3-month post-surgical outcome, and critical complications were evaluated. RESULTS: Two patients (treated during our earliest use of endoscope) who underwent surgery on the 7th and 16th day post-onset required subsequent cerebrospinal shunt surgery. In contrast, of the 11 patients who underwent endoscopic surgery on the day of onset, only 1 patient required an additional, third ventriculostomy due to a secondary obstruction of the aqueduct by adhesive fibrous membranes. After 3 months, all six patients with mRS scores of 2-3 satisfied all the following criteria: initial Glasgow Coma Scale scores higher than 8, flexible endoscopic surgeries performed on the day of onset, and period of ventricular drainage of less than 4 days. CONCLUSIONS: Early surgical intervention using a flexible endoscope and short period of post-surgical drainage can be highly effective for patients suffering from casting intraventricular hematomas associated with intracerebral hemorrhage. The advantages of this treatment may be a less invasive procedure, ICP control in the acute phase, breaking away from ventricular drainage in the early stage, and prevention of hydrocephalus or intracranial infectious complications in the long term.
Assuntos
Hemorragia Cerebral/cirurgia , Ventrículos Cerebrais/cirurgia , Hematoma/cirurgia , Neuroendoscopia/métodos , Ventriculostomia/métodos , Idoso , Idoso de 80 Anos ou mais , Hemorragia Cerebral/complicações , Drenagem , Intervenção Médica Precoce , Feminino , Escala de Coma de Glasgow , Hematoma/etiologia , Humanos , Masculino , Pessoa de Meia-Idade , Hemorragia Putaminal/complicações , Hemorragia Putaminal/cirurgia , Estudos Retrospectivos , Tálamo , Resultado do TratamentoRESUMO
M1 fenestration of the middle cerebral artery is rare. We present two patterns of acute thromboembolic conditions in M1 fenestrations treated with mechanical thrombectomy. Case 1 was a male in his 60s presenting with right hemiparesis and aphasia. Angiography showed acute left M1 proximal occlusion; the first direct aspiration revealed two parallel routes, and the second aspiration achieved complete recanalization of the left M1 fenestration. Case 2 was a male in his 70s presenting right hemiparesis and aphasia. Angiography revealed a sudden stair-like narrowing of the left M1 in the intermediate part, and a retrograde blood flow cavity was observed on the upper side of the distal part. Mechanical thrombectomy was performed to diagnose the upper limb occlusion of the left M1 fenestration, and successful recanalization was achieved through direct aspiration. Anatomical variations, such as fenestration, should be considered to reduce complication risks.
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We herein report a case of left twisted carotid bifurcation (TCB) that newly appeared on follow-up examination. The patient was a 71-year-old woman with neck bruit and hyperlipidemia underwent neck magnetic resonance angiography. The left carotid bifurcation showed a normal branching pattern. Two years later, a follow-up examination was performed, and the left internal carotid artery (ICA) ran medial to the external carotid artery (ECA), indicating TCB. On the right side, the ICA ran dorsal to the ECA. The prevalence of TCB is reported to be 3.6%-15.1%. According to a review of the relevant literature, >80% of TCBs were found on the right side. TCB is generally considered to be a result of excessive lateral migration of the ECA during embryogenesis, and age-related atherosclerotic elongation and tortuosity of the carotid arteries may be another cause. In the case of TCB, carotid endarterectomy (CEA) is slightly difficult and slightly dangerous, because the affected ICA lies behind the ECA, and superior laryngeal nerve injury rarely occurs. TCB is not uncommon, but there is greater frequency on the right side. It may also newly develop. It is important to conduct a radiological evaluation of TCB before performing CEA.
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Vertebrobasilar artery dissection is an uncommon cause of acute ischaemic stroke (AIS). Optimal endovascular management has not been established. This study aimed to share our experience with endovascular reperfusion therapy for vertebrobasilar artery occlusion due to vertebral artery dissection (VAD). We retrospectively reviewed 134 consecutive patients with AIS who received urgent endovascular reperfusion therapy between November 2017 and November 2019. Three patients diagnosed with VAD were investigated. The evaluation included mechanisms of vertebrobasilar artery occlusion due to VAD, variations in endovascular procedures, and functional outcomes. Dissections at the V3, V4 and extension of V3 to V4 segments were seen in one patient each. The mechanism of AIS was different in each patient: occlusion of the distal non-dissected artery due to an embolus from the dissection site (distal occlusion), haemodynamic collapse of the entire vertebrobasilar artery system due to the arterial dissection itself (local occlusion), or coexistence of distal occlusion and local occlusion (tandem occlusion). The endovascular reperfusion therapy was performed corresponding to the abovementioned mechanisms: mechanical thrombectomy for distal occlusion, stenting for local occlusion, and a combination of thrombectomy and stenting for tandem occlusion. In all three patients, effective recanalization and functional independence (modified Rankin Scale scores of 0-2 at 90 days after the onset) were achieved. Endovascular treatment corresponding to the individual mechanism of AIS may improve patient outcomes.
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The aim of this study is to analyze the usefulness of 64-raw multislice computed tomography (CT) scans and bone images of three-dimensional CT (3D-CT) scans for evaluation of mild head injuries in children. Thirteen children (9 boys and 4 girls, less than or equal to 15 years old) with mild head injury were included in the study. Head CT scans obtained within 24 hours after injury. All children had no episodes of loss of consciousness, amnesia, epilepsy, vomiting, and no neurological abnormality on arrival at hospital. We detected 9 positive findings on CT scans, which looked like fracture lines at the frontal bone in 7 cases. The bone images of CT axial views revealed a true fracture in one case in which a skull X-ray could not demonstrate a fracture line, but, other positive findings turned out to be a diploic vein surrounded by a thin bone cortex. All false positive findings were detected in the patients under the age of 6. By the 3D-reconstructive CT scan, it is easier to detect not only the intracranial lesions but also the cranial fracture. But, the diploic vein is apt to be misdiagnosed as the fracture line, especially in patients under the age of 6.
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Traumatismos Craniocerebrais/diagnóstico por imagem , Tomografia Computadorizada por Raios X/métodos , Adolescente , Criança , Pré-Escolar , Feminino , Cabeça/diagnóstico por imagem , Humanos , Lactente , MasculinoRESUMO
BACKGROUND: Phosphenes, flashes of light, are a visual phenomenon experienced by patients with ophthalmological disease and normal individuals. CASE REPORT: We report here a 68-year-old woman in whom phosphenes appeared in the left visual field due to compression of the right optic nerve by an aneurysm of the anterior communicating artery. RESULTS: The symptom decreased dramatically after clipping of the aneurysm. CONCLUSION: Phosphenes may be an important early sign of vascular compression neuropathy of the optic nerve.
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Aneurisma Intracraniano/complicações , Hipertensão Intracraniana/complicações , Doenças do Nervo Óptico/etiologia , Doenças do Nervo Óptico/fisiopatologia , Fosfenos/fisiologia , Idoso , Artéria Cerebral Anterior/diagnóstico por imagem , Artéria Cerebral Anterior/patologia , Artéria Cerebral Anterior/cirurgia , Angiografia Cerebral , Craniotomia , Progressão da Doença , Diagnóstico Precoce , Feminino , Fraturas por Compressão/complicações , Fraturas por Compressão/etiologia , Humanos , Imageamento Tridimensional , Aneurisma Intracraniano/patologia , Aneurisma Intracraniano/cirurgia , Hipertensão Intracraniana/etiologia , Hipertensão Intracraniana/fisiopatologia , Imageamento por Ressonância Magnética , Microcirurgia , Procedimentos Neurocirúrgicos , Nervo Óptico/diagnóstico por imagem , Nervo Óptico/patologia , Nervo Óptico/cirurgia , Doenças do Nervo Óptico/patologia , Fraturas da Coluna Vertebral/complicações , Fraturas da Coluna Vertebral/etiologia , Instrumentos Cirúrgicos , Resultado do TratamentoRESUMO
We report here a rare case of supratentorial ectopic cortical ependymoma. This tumor was localized in the left angular gyrus, occurred with intratumoral hemorrhage, was attached to the dura mater, exhibited no continuity with the ventricular system, showed distinctive pathological features (perivascular pseudo-rosette formations and firework-like giant rosette formations), and finally transformed to a glioblastoma-like high-grade lesion. A cortical ependymoma should be considered in the differential diagnosis of supratentorial cortical tumors with intraparenchymal hemorrhage and high vascularity, even if not in contact with the ventricular system. Although malignant transformation is unusual in cortical ependymoma, close observation and adjunctive radiotherapy are strongly recommended after the excision.
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Ependimoma/patologia , Glioblastoma/patologia , Recidiva Local de Neoplasia/patologia , Segunda Neoplasia Primária/patologia , Neoplasias Supratentoriais/patologia , Adulto , Ependimoma/metabolismo , Ependimoma/cirurgia , Glioblastoma/metabolismo , Glioblastoma/cirurgia , Hemorragia/etiologia , Humanos , Imageamento por Ressonância Magnética , Masculino , Recidiva Local de Neoplasia/metabolismo , Recidiva Local de Neoplasia/cirurgia , Segunda Neoplasia Primária/metabolismo , Segunda Neoplasia Primária/cirurgia , Neoplasias Supratentoriais/metabolismo , Neoplasias Supratentoriais/cirurgia , Tomografia Computadorizada por Raios XRESUMO
Anterior wall aneurysms of the internal carotid artery (AWAICA) are relatively uncommon. We investigated the distribution of the subarachnoid clot on computerized tomography (CT) scans in patients with ruptured AWAICA and compared the findings with those in patients with internal carotid artery aneurysms (ICAA) at other sites. Twenty-six ruptured ICAA patients were included in this study. Four (15.4%) of these had an AWAICA and 22 had an ICAA at other sites. Three of the 4 patients with AWAICA had an ordinary 'saccular type' aneurysm and the other had a 'blood blister-like' aneurysm. In all three patients with a 'saccular type' AWAICA, accumulation of the subarachnoid clot in the olfactory sulcus was noted on CT scan. In the patient with a 'blood blister-like' aneurysm and in 22 patients with ICAA at other sites, there were no specific correlations between focal accumulations of the subarachnoid clot and aneurysm location. The accumulation of subarachnoid clot in the olfactory sulcus on CT scan may suggest a ruptured 'saccular type' AWAICA.
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Aneurisma/diagnóstico por imagem , Doenças das Artérias Carótidas/diagnóstico por imagem , Artéria Carótida Interna/diagnóstico por imagem , Hemorragia Subaracnóidea/diagnóstico por imagem , Aneurisma Roto/diagnóstico por imagem , Angiografia Cerebral , Lateralidade Funcional , Humanos , Aneurisma Intracraniano/diagnóstico por imagem , Artéria Oftálmica/diagnóstico por imagem , Tomografia Computadorizada por Raios XRESUMO
Three cases of an extremely rare anomaly of the carotid artery are described herein. In these patients, the common carotid arteries, without bifurcation in the cervical portion, supplied multiple arterial branches, which are more commonly branches of the external carotid artery. The non-bifurcating carotid artery continued into the cranium as a normal internal carotid artery. This anomaly can be attributed to a maldevelopment of the vascular network during embryogenesis.
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Encéfalo/irrigação sanguínea , Artéria Carótida Primitiva/anormalidades , Artéria Carótida Externa/anormalidades , Artéria Carótida Interna/anormalidades , Cabeça/irrigação sanguínea , Idoso , Artéria Carótida Primitiva/diagnóstico por imagem , Artéria Carótida Externa/diagnóstico por imagem , Artéria Carótida Interna/diagnóstico por imagem , Seio Cavernoso/patologia , Seio Cavernoso/fisiopatologia , Angiografia Cerebral/normas , Feminino , Humanos , Masculino , Hemorragia Subaracnóidea/diagnóstico , Hemorragia Subaracnóidea/patologia , Hemorragia Subaracnóidea/fisiopatologia , Tomografia Computadorizada por Raios XRESUMO
BACKGROUND: We report a case of infratentorial arteriovenous malformation (AVM) associated with persistent primitive hypoglossal artery (PPHA). To our knowledge, this is the second reported case of these combined anomalies in the English literature. We discuss the embryological relationship between these two congenital vascular anomalies. CASE DESCRIPTION: An 18-year-old girl, who suddenly developed severe headache and vomiting followed by loss of consciousness, was admitted to our hospital. A computed tomography scan showed intracerebellar hemorrhage with obstructive hydrocephalus. Digital subtraction angiography revealed an AVM in the left cerebellar hemisphere and an ipsilateral PPHA. After the intracranial pressure was stabilized, the AVM was surgically removed. AVMs develop during the 4(th) to 8(th) week of embryonic life. In contrast, carotid-basilar anastomoses (CBAs) including primitive hypoglossal arteries appear and close spontaneously by the 6(th) week of embryonic life. Thus, AVMs precede CBAs, and a large amount of blood flows into the adjoining AVM via ipsilateral CBAs. As a result, spontaneous closure of a CBA may be disturbed. CONCLUSION: We speculate that coexistence of infratentorial AVMs and ipsilateral CBAs is not incidental but inevitable.
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Proximal ligation of the internal carotid artery (ICA) with high-flow bypass is one of the surgical strategies for treating large, unclippable ICA aneurysms. We encountered a rare case of recanalization of a large ICA aneurysm that disappeared after high-flow bypass surgery, and subsequently reappeared via an elicited vertebral artery (VA)-ICA anastomosis (anastomosis between the anterior meningeal artery branching from the right VA, and the ascending pharyngeal artery branching (APA) from the right ICA). To the best of our knowledge, this is the first case report describing angiographical recurrence of a large ICA aneurysm after the surgery. Periodic long-term follow-up by neuroimaging may be necessary after this surgery, particularly in cases of ICA proximal ligation with the ICA aneurysm, when the APA has not been clearly identified as a branch from the ipsilateral external carotid artery on the preoperative angiogram.
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Doenças das Artérias Carótidas/diagnóstico , Artéria Carótida Interna/cirurgia , Aneurisma Intracraniano/diagnóstico , Artéria Vertebral/cirurgia , Anastomose Cirúrgica , Angiografia , Doenças das Artérias Carótidas/diagnóstico por imagem , Doenças das Artérias Carótidas/cirurgia , Artéria Carótida Interna/diagnóstico por imagem , Revascularização Cerebral , Diagnóstico Diferencial , Feminino , Humanos , Aneurisma Intracraniano/diagnóstico por imagem , Aneurisma Intracraniano/cirurgia , Masculino , Pessoa de Meia-Idade , Recidiva , Artéria Vertebral/diagnóstico por imagemRESUMO
This report describes 2-week and 20-month histopathologic findings in small aneurysms embolized with platinum coils. Electron microscopy showed the presence of endothelial cells encroaching on the platinum coils at the orifice of the aneurysm in both cases. We confirm that endothelial growth can be induced as early as 2 weeks after embolization of small human aneurysms with platinum coils, similar to previous observations in animal models and human cases.
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Embolização Terapêutica/instrumentação , Embolização Terapêutica/métodos , Aneurisma Intracraniano/patologia , Aneurisma Intracraniano/terapia , Platina , Idoso , Angiografia Cerebral , Desenho de Equipamento , Humanos , Aneurisma Intracraniano/diagnóstico por imagem , Masculino , Microscopia Eletrônica de Varredura , Pessoa de Meia-IdadeRESUMO
The aim of this study was to assess the subcellular localization of basic fibroblast growth factor (bFGF) and fibroblast growth factor receptor 1 (FGFR1) in pituitary adenomas. We studied 61 patients who had primary pituitary adenomas and underwent operation. The immunohistochemistry for bFGF, FGFR1, and MIB-1 was examined in paraffin-embedded tissues. The bFGF immunoreactivity in the nucleus was recorded as the bFGF nuclear index, which was calculated as the percentage of tumor cells with the bFGF immunoreactivity in the nuclei when more than 1000 tumor cells were examined. Recurrent adenomas were found in 7 patients during follow-up periods ranging from 8 to 134 months (mean, 57.2). The recurrent adenomas had significantly larger mean bFGF nuclear indices (74.8 +/- 28.8%) than the nonrecurrent adenomas (25.4 +/- 32.1%, P = 0.0003). The bFGF nuclear index also correlated significantly with the maximum tumor diameters and the invasiveness to the cavernous sinuses (Knosp grade) in the adenomas. The cytoplasmic FGFR1 immunoreactivity was inversely correlated (P < 0.02) with maximum tumor diameter. Neither cytoplasmic bFGF, cytoplasmic FGFR1, nor MIB-1 staining index showed any relationship with the recurrence of pituitary adenomas. These findings suggest that the nuclear accumulation of bFGF plays an important role in the progression of pituitary adenomas without its receptors.
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Adenoma/metabolismo , Fator 2 de Crescimento de Fibroblastos/metabolismo , Recidiva Local de Neoplasia/metabolismo , Neoplasias Hipofisárias/metabolismo , Receptores Proteína Tirosina Quinases/metabolismo , Receptores de Fatores de Crescimento de Fibroblastos/metabolismo , Adenoma/diagnóstico por imagem , Adenoma/patologia , Adolescente , Adulto , Idoso , Feminino , Humanos , Imuno-Histoquímica , Antígeno Ki-67/metabolismo , Masculino , Pessoa de Meia-Idade , Recidiva Local de Neoplasia/patologia , Neoplasias Hipofisárias/diagnóstico por imagem , Neoplasias Hipofisárias/patologia , Prolactinoma/diagnóstico por imagem , Prolactinoma/metabolismo , Prolactinoma/patologia , Radiografia , Receptor Tipo 1 de Fator de Crescimento de Fibroblastos , Estudos RetrospectivosRESUMO
We retrospectively studied 133 patients with subarachnoid hemorrhage (SAH) to assess whether there was any gender disparity in serum electrolytes levels throughout the clinical course. Serum concentrations of sodium and potassium were measured in all patients, while catecholamines or antidiuretic hormone were assessed in a number of cases. Female SAH-patients had lower potassium level (3.29 +/- 0.47 mEq/L) than did male patients (3.68 +/-0.38) on the first day of SAH. This gender disparity continued to the beginning of the chronic phase and disappeared several months later. Mean serum sodium level was lower in the male group than in the female group throughout the clinical course. Mean serum levels of adrenaline and antidiuretic hormone were characterized by their prominent high value on the first day. Serum potassium levels were inversely related to serum levels of catecholamines, especially adrenaline, during the acute and subacute phases, particularly on the first day.
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Eletrólitos/sangue , Caracteres Sexuais , Hemorragia Subaracnóidea/sangue , Adulto , Idoso , Idoso de 80 Anos ou mais , Catecolaminas/sangue , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neurofisinas/sangue , Potássio/sangue , Precursores de Proteínas/sangue , Estudos Retrospectivos , Sódio/sangue , Estatísticas não Paramétricas , Vasopressinas/sangueRESUMO
Usually, dementia, gait disturbance and urinary incontinence are an integral part of the clinical presentation of normal pressure hydrocephalus (NPH). However, NPH with transient visual cognitive disorders has not been reported previously. We herein describe an extremely rare case of NPH that presented with transient visual cognitive disorders and long lasting visual memory disturbances that subsided after CSF shunting. A 38-years-old man developed transient prosopagnosia, topographical disorientation, color vision disturbance, and visual objective agnosia that progressed over 5 years. Magnetic resonance images showed ventriculomegaly with ischemic lesions in the paraventricular deep white matter. ECD-SPECT showed a reduction of the cerebral blood flow (CBF) in the periventricular deep white matter. Three months after CSF shunting, the radiological findings normalized with dramatic improvement of the extremely rare symptoms.
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Agnosia/etiologia , Confusão/etiologia , Hidrocefalia de Pressão Normal/psicologia , Prosopagnosia/etiologia , Adulto , Agnosia/psicologia , Ventrículos Cerebrais/diagnóstico por imagem , Ventrículos Cerebrais/patologia , Ventriculografia Cerebral , Confusão/psicologia , Cisteína/análogos & derivados , Humanos , Hidrocefalia de Pressão Normal/diagnóstico por imagem , Hidrocefalia de Pressão Normal/cirurgia , Imageamento por Ressonância Magnética , Masculino , Transtornos da Memória/etiologia , Transtornos da Memória/psicologia , Compostos de Organotecnécio , Prosopagnosia/psicologia , Compostos Radiofarmacêuticos , Tomografia Computadorizada de Emissão de Fóton Único , Tomografia Computadorizada por Raios X , Derivação VentriculoperitonealRESUMO
The present study was designed to assess the relationship between the presence of focal brain aedema and serum concentrations of atrial natriuretic peptide (ANP) or brain natriuretic peptide (BNP) in patients with subarachnoid haemorrhage (SAH). Serum levels of ANP and BNP were measured at six different time periods (Day 1, 2, 3, 4 to 7, 8 to 14, and 15 to 25) in 61 SAH-patients. Focal brain aedema, which was caused by an intracerebral haematoma associated with SAH or surgical complications, was found in eight SAH-patients by means of consecutive CT scans. The mean serum ANP and BNP levels in patients with focal brain aedema were significantly higher than those in patients without focal brain aedema between Days 4 and 14. These findings suggest that focal brain aedema may have some role in the pathogenesis of an excessive secretion of ANP and BNP during the subacute phase of SAH.
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Fator Natriurético Atrial/sangue , Edema Encefálico/etiologia , Peptídeo Natriurético Encefálico/metabolismo , Hemorragia Subaracnóidea/complicações , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Estatísticas não Paramétricas , Hemorragia Subaracnóidea/sangue , Fatores de TempoRESUMO
Propionibacterium acnes are gram-positive pleomorphic rods that grow under an anaerobic condition. They are the most frequent inhabitants of sebaceous glands of skin, hair follicles, mouth, upper respiratory tract, and as a frequent contaminant in laboratory cultures. Propionibacterium acnes is an underestimated but significant cause of postneurosurgical infection, especially in the presence of foreign bodies such as shunt systems. We present a rare case with a postoperative subdural empyema in which the only pathogen isolated was Propionibacterium acnes. In our case, the clinical course was atypically rapid. The most effective antibiotic therapy for Propionibacterium acnes infections has not been established. However, high dose penicillin in combination with surgical drainage and removal of foreign bodies is recommended as the treatment of choice.
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Empiema Subdural/etiologia , Infecções por Bactérias Gram-Positivas/etiologia , Propionibacterium acnes , Empiema Subdural/terapia , Feminino , Infecções por Bactérias Gram-Positivas/terapia , Humanos , Pessoa de Meia-Idade , Complicações Pós-OperatóriasRESUMO
OBJECT: Chronic subdural hematoma (CSDH) is a common condition after head trauma. It can often be successfully treated surgically by inserting a bur hole and draining the liquefied hematoma. However, to the best of the authors' knowledge, for nonemergency cases not requiring surgery, no reports have indicated the best approach for preventing hematoma enlargement or resolving it completely. The authors hypothesized that hyperfibrinolysis plays a major role in liquefaction of the hematoma. Therefore, they evaluated the ability of an antifibrinolytic drug, tranexamic acid, to completely resolve CSDH compared with bur hole surgery alone. METHODS: From 2007 to 2011, a total of 21 patients with CSDH seen consecutively at Kuki General Hospital, Japan, were given 750 mg of tranexamic acid orally every day. Patients were identified by a retrospective records review, which collected data on the volume of the hematoma (based on radiographic measurements) and any complications. Follow-up for each patient consisted of CT or MRI every 21 days from diagnosis to resolution of the CSDH. RESULTS: Of the 21 patients, 3 with early stages of CSDH were treated by bur hole surgery before receiving medical therapy. The median duration of clinical and radiographic follow-up was 58 days (range 28-137 days). Before tranexamic acid therapy was initiated, the median hematoma volume for the 21 patients was 58.5 ml (range 7.5-223.2 ml); for the 18 patients who had not undergone surgery, the median hematoma volume was 55.6 ml (range 7.5-140.5 ml). After therapy, the median volume for all 21 patients was 3.7 ml (range 0-22.1 ml). No hematomas recurred or progressed. CONCLUSIONS: Chronic subdural hematoma can be treated with tranexamic acid without concomitant surgery. Tranexamic acid might simultaneously inhibit the fibrinolytic and inflammatory (kinin-kallikrein) systems, which might consequently resolve CSDH. This medical therapy could prevent the early stages of CSDH that can occur after head trauma and the recurrence of CSDH after surgery.
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Antifibrinolíticos/uso terapêutico , Encéfalo/diagnóstico por imagem , Hematoma Subdural Crônico/tratamento farmacológico , Ácido Tranexâmico/uso terapêutico , Idoso , Idoso de 80 Anos ou mais , Encéfalo/cirurgia , Terapia Combinada , Feminino , Hematoma Subdural Crônico/diagnóstico por imagem , Hematoma Subdural Crônico/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Radiografia , Prevenção Secundária , Resultado do TratamentoRESUMO
BACKGROUND: Most of the results regarding hydrogen (H2) therapy for acute cerebral ischemia are derived from in vitro studies and animal experiments, with only a few obtained from human trials with a limited number of subjects. Thus, there is a paucity of information regarding both the beneficial therapeutic effects as well as the side effects of H2 on acute cerebral ischemia in humans. We designed a pilot study to investigate single dose intravenous H2-administration in combination with edaravone, aiming to provide an initial estimate of the possible risks and benefits in select patients presenting with acute ischemic stroke. METHODS: An open-label, prospective, non-randomized study of intravenous H2-administration was performed in 38 patients hospitalized for acute ischemic stroke. All patients received an H2-enriched intravenous solution in addition to edaravone immediately after the diagnosis of acute ischemic stroke. Acute stroke patients within 3 h of onset received intravenous tissue plasminogen activator (t-PA) (0.6 mg/kg) treatment, and patients receiving t-PA had to commence the administration of the H2-enriched intravenous solution and edaravone before or at the same time as the t-PA was infused. RESULTS: Complications were observed in 2 patients (5.3%), which consisted of diarrhea in 1 patient (2.6%) and cardiac failure in 1 patient (2.6%). No deterioration in laboratory tests, urinary tests, ECG, or chest X-ray radiograms occurred in any patient in this study. In all patients, the mean National Institutes of Health Stroke Scale (NIHSS) scores at baseline, and 7, 30, and 90 d after admission were 8.2 ± 7.5, 5.6 ± 7.1, 4.9 ± 6.5, and 4.5 ± 6.3, respectively. The early recanalization was identified in 4 of 11 patients (36.4%) who received intravenous t-PA administration. Hemorrhagic transformation was observed in 2 patients (18.2%). None of the patients in this study that were treated with t-PA developed symptomatic intracranial hemorrhage. CONCLUSIONS: Data from the current study indicate that an H2-enriched intravenous solution is safe for patients with acute cerebral infarction, including patients treated with t-PA.