Detalhe da pesquisa
1.
Machine learning-driven multiscale modeling reveals lipid-dependent dynamics of RAS signaling proteins.
Proc Natl Acad Sci U S A
; 119(1)2022 01 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34983849
2.
Exploring CRD mobility during RAS/RAF engagement at the membrane.
Biophys J
; 121(19): 3630-3650, 2022 10 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35778842
3.
RAS internal tandem duplication disrupts GTPase-activating protein (GAP) binding to activate oncogenic signaling.
J Biol Chem
; 295(28): 9335-9348, 2020 07 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32393580
4.
New weapons to penetrate the armor: Novel reagents and assays developed at the NCI RAS Initiative to enable discovery of RAS therapeutics.
Semin Cancer Biol
; 54: 174-182, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29432816
5.
Englerin A Inhibits EWS-FLI1 DNA Binding in Ewing Sarcoma Cells.
J Biol Chem
; 291(19): 10058-66, 2016 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26961871
6.
Quantitative analysis of F-actin redistribution in astrocytoma cells treated with candidate pharmaceuticals.
Cytometry A
; 85(6): 512-21, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24515854
7.
Studying RAS Interactions in Live Cells with BRET.
Methods Mol Biol
; 2797: 253-260, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38570465
8.
Comparative analysis of KRAS4a and KRAS4b splice variants reveals distinctive structural and functional properties.
Sci Adv
; 10(7): eadj4137, 2024 Feb 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38354232
9.
Membrane lipids drive formation of KRAS4b-RAF1 RBDCRD nanoclusters on the membrane.
Commun Biol
; 7(1): 242, 2024 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38418613
10.
RAS-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome-associated cardiac hypertrophy.
Sci Adv
; 9(28): eadf4766, 2023 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37450595
11.
Direct Modulators of K-Ras-Membrane Interactions.
ACS Chem Biol
; 18(9): 2082-2093, 2023 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37579045
12.
Machine Learning-Driven Multiscale Modeling: Bridging the Scales with a Next-Generation Simulation Infrastructure.
J Chem Theory Comput
; 19(9): 2658-2675, 2023 May 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37075065
13.
Recapitulation of cell-like KRAS4b membrane dynamics on complex biomimetic membranes.
iScience
; 25(1): 103608, 2022 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35106460
14.
Virtual screening for small-molecule pathway regulators by image-profile matching.
Cell Syst
; 13(9): 724-736.e9, 2022 09 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36057257
15.
Asynchronous Reciprocal Coupling of Martini 2.2 Coarse-Grained and CHARMM36 All-Atom Simulations in an Automated Multiscale Framework.
J Chem Theory Comput
; 18(8): 5025-5045, 2022 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35866871
16.
RAS Nanoclusters: Dynamic Signaling Platforms Amenable to Therapeutic Intervention.
Biomolecules
; 11(3)2021 03 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33802474
17.
Membrane interactions of the globular domain and the hypervariable region of KRAS4b define its unique diffusion behavior.
Elife
; 92020 01 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31958057
18.
Synthesis of a 35-member stereoisomer library of bistramide A: evaluation of effects on actin state, cell cycle and tumor cell growth.
J Org Chem
; 74(5): 1897-916, 2009 Mar 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-19191575
19.
Intercellular Transfer of Oncogenic KRAS via Tunneling Nanotubes Introduces Intracellular Mutational Heterogeneity in Colon Cancer Cells.
Cancers (Basel)
; 11(7)2019 Jun 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-31247990
20.
Author Correction: Membrane lipids drive formation of KRAS4b-RAF1 RBDCRD nanoclusters on the membrane.
Commun Biol
; 7(1): 445, 2024 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38605143