Behavioral and Neural Trajectories of Risk Taking for Peer and Parent in Adolescence.

One feature of adolescence is a rise in risk-taking behaviors, whereby the consequences of adolescents' risky action often impact their immediate surrounding such as their peers and parents (vicarious risk taking). Yet, little is known about how vicarious risk taking develops, particularly depending on who the risk affects and the type of risky behavior. In a 3-wave longitudinal fMRI study, 173 adolescents completed 1-3 years of a risky decision-making task where they took risks to win money for their best friend and parent (n with behavioral and fMRI data ranges from 139-144 and 100-116 participants, respectively, per wave). Results of this preregistered study suggest that adolescents did not differentially take adaptive (sensitivity to the expected value of reward during risk taking) and general (decision-making when the expected values of risk taking and staying safe are equivalent) risks for their best friend and parent from sixth to ninth grade. At the neural level, preregistered ROI analyses revealed no differences in the ventral striatum and ventromedial pFC during general nor adaptive risk taking for best friend versus parent over time. Furthermore, exploratory longitudinal whole-brain analyses revealed subthreshold differences between best friend and parent trajectories within regulatory regions during general vicarious risk taking and social-cognitive regions during adaptive vicarious risk taking. Our findings demonstrate that brain regions implicated in cognitive control and social-cognitive processes may distinguish behaviors involving peers and parents over time.

Maternal Neurobiological Processing of Negative Adolescent Stimuli: Relations With Positive Parenting and Relationship Quality.

We examined associations between maternal affective neurobiology and positive parenting in a study of 20 mothers of adolescents. Mothers underwent functional magnetic resonance imaging during an emotion image task, rated parent-adolescent relationship quality, and completed an adolescent interaction task in which positive parenting behaviors were observed. Maternal structure was associated with lower responsivity in emotional processing regions in the general negative image contrast and was related to greater dorsolateral prefrontal cortex activation to negative adolescent images. Parent-adolescent relationship quality was associated with lower precuneus activation to negative adolescent images. Findings are among the first to connect functional brain processing with observed parenting behaviors for parents of adolescent children, and underscore the relative importance of affective processing in parenting older children.

Difficulties in Emotion Regulation Predict Depressive Symptom Trajectory from Early to Middle Adolescence.

Major depressive disorder begins to increase in early adolescence and is associated with significant impairment (e.g., suicidality). Difficulties in emotion regulation (ER) have been associated with depressive symptoms; however, little research has examined this relation over time beginning in early adolescence. Starting when they were 11-14 years old, 246 adolescents (nboys = 126; nwhite = 158) completed self-report questionnaires on their ER at Time 1 and depressive symptoms every year for 2 years. Results revealed that overall difficulties in ER (and limited access to ER strategies) at Time 1 predicted depressive symptoms both cross-sectionally and longitudinally. Gender moderated this relation cross-sectionally, such that higher overall ER difficulties at Time 1 was more strongly associated with higher depressive symptoms for girls than for boys. These findings suggest that depression prevention efforts should promote adaptive ER in early adolescence, particularly for girls, in order to prevent the increases in depressive symptoms seen into middle adolescence.

Developmental change in emotion expression in frustrating situations: The roles of context and gender.

Emotion expression is a central aspect of social-emotional functioning. Theorists assert that emotion expression undergoes significant changes in the preschool period. There is, however, limited observational evidence of those changes, which may vary by interpersonal context and gender. The present longitudinal study examined developmental changes in emotion expressions from ages 3 to 5 years in 120 children from rural economically strained families. Children's facial, vocal, and postural sadness, anger, and happiness expressions were observed in frustrating tasks in 3 social contexts (a perfect circles task with an experimenter, a toy wait task with mother, a locked box task when alone). Findings indicted that sadness expressions decreased with age in all 3 contexts. Anger expressions increased with age in the frustrating task with the experimenter and when alone but not with the mother. From age 4 to 5 years, happiness expressions decreased in the task with experimenter but increased when alone and increased marginally with mother. In terms of gender, girls expressed greater happiness (and lower sadness) than boys but only in the task with the experimenter. Findings suggest that sadness expressions decrease over the preschool years. Developmental changes in happiness and anger expressions (and gender differences) likely depend on context.

A person-centered approach to adolescent emotion regulation: Associations with psychopathology and parenting.

Adolescence is a unique period of heightened emotional arousal and still-developing regulatory abilities. Adolescent emotion regulation patterns may be critically involved in adolescents' psychosocial development, but patterns of emotion regulation in youths are not well understood. The current study used latent profile analysis (LPA) to elucidate patterns of emotion expression, experience, and emotion-related physiological arousal in adolescents. A sample of 198 adolescents and their primary caregivers participated in an emotionally arousing parent-adolescent conflict interaction. Adolescents' observed emotion expressions, emotion experiences, and heart rate (HR) and caregiver parenting behaviors were assessed during and/or after the interaction. Parents reported on adolescents' internalizing and externalizing symptoms, and youths reported on depressive symptoms. The LPA revealed four emotion regulation profiles: a moderate HR and high expression profile, a suppression profile (with low negative emotion expression and high emotion experience), a low reactive profile, and a high reactive profile. The moderate HR and high expression profile was associated with lower conduct disorder symptoms, the suppression profile was related to lower anxiety symptoms, and the high reactive profile was associated with higher adolescent depressive symptoms. The high reactive profile and moderate HR and high expression profile were associated with more negative/critical parenting behaviors. Findings suggest that profiles of adolescent emotion regulation can be empirically identified and may be significant risk factors for psychopathology.

Self-oriented neural circuitry predicts other-oriented adaptive risks in adolescence: a longitudinal study.

Adolescence is marked by changes in decision-making and perspective-taking abilities. Although adolescents make more adaptive decisions with age, little is understood about how adolescents take adaptive risks that impact others and how this behavior changes developmentally. Functional coupling between reward [e.g., ventral striatum (VS)] and 'social brain' [e.g. temporal parietal junction (TPJ)/ posterior superior temporal sulcus (pSTS), medial prefrontal cortex (mPFC)] systems may be differentially shape adaptive risks for the self and other. A total of 173 participants completed between one and three sessions across three waves [a total of 433 behavioral and 403 functional magnetic resonance imaging (fMRI) data points]. During an fMRI scan, adolescents completed a risky decision-making task where they made risky decisions to win money for themselves and their parent. The risky decisions varied in their expected value (EV) of potential reward. Results show that from the 6th through 9th grades, adolescents took increasingly more adaptive risks for themselves than for their parent. Additionally, greater VS-TPJ/pSTS and VS-mPFC connectivity that tracks EV when making risky decisions for themselves in 6th grade, but a lower VS-mPFC connectivity in 9th grade, predicted greater adaptive risk-taking for their parent. This study contributes to our understanding of the self as a neural proxy for promoting adaptive social behaviors in youth.

Positive risk taking and neural sensitivity to risky decision making in adolescence.

This study examines associations between adolescents' positive risk taking and neural activation during risky decision-making. Participants included 144 adolescents ages 13-16 years (Mage = 14.23; SDage = 0.7) from diverse racial and ethnic groups. Participants self-reported their engagement in positive and negative risk taking. Additionally, participants played the Cups task during fMRI, where they chose between a safe choice (guaranteed earning of 15 cents) and a risky choice (varying probabilities of earning more than 15 cents). Using a risk-return framework, we examined adolescents' sensitivity to both risks (safe versus risky) and returns (expected value, or potential reward as a function of its probability of occurring) at the behavioral and neural levels. All participants took more risks when the expected value of the choice was high. However, high positive risk taking was uniquely associated with dampened dmPFC tracking of expected value. Together, results show that adolescents' positive risk taking is associated with neural activity during risky decision-making. Findings are among the first to identify brain-behavior correlations associated with positive risk taking during adolescence.

Social neural sensitivity as a susceptibility marker to family context in predicting adolescent externalizing behavior.

Adolescence represents a period of risk for developing patterns of risk-taking and conduct problems, and the quality of the family environment is one robust predictor of such externalizing behavior. However, family factors may not affect all youth uniformly, and individual differences in neurobiological susceptibility to the family context may moderate its influence. The current study investigated brain-based individual differences in social motivational processing as a susceptibility marker to family conflict in predicting externalizing behavior in early adolescent youth. 163 adolescents (Mage = 12.87 years) completed an fMRI scan during which they anticipated social rewards and social punishments. For adolescents with heightened ventral striatum and amygdala blood oxygen-level dependent (BOLD) response during the anticipation of social rewards and heightened ventral striatum BOLD response during the anticipation of social punishments, higher levels of family conflict were associated with greater externalizing behavior. BOLD response when anticipating both social rewards and punishments suggested increased susceptibility to maladaptive family contexts, highlighting the importance of considering adolescent social motivation in positive and negatively valenced contexts.

Affective Neural Mechanisms of a Parenting-Focused Mindfulness Intervention.

OBJECTIVES: Behavioral evidence suggests that parenting-focused mindfulness interventions can improve parenting practices and enhance family wellbeing, potentially operating through altered emotional processing in parents. However, the mechanisms through which parent mindfulness interventions achieve their positive benefits have not yet been empirically tested, knowledge which is key to refine and maximize intervention effects. Thus, as part of a randomized controlled trial, the present study examined the affective mechanisms of an 8-week parenting-focused mindfulness intervention, the Parenting Mindfully (PM) intervention, versus a minimal-intervention parent education control. METHODS: Twenty highly stressed mothers of adolescents completed pre- and post-intervention behavioral and fMRI sessions, in which mothers completed a parent-adolescent conflict interaction, fMRI emotion task, and fMRI resting state scan. Mothers reported on their mindful parenting, and maternal emotional reactivity to the parent-adolescent conflict task was assessed via observed emotion expression, self-reported negative emotion, and salivary cortisol reactivity. RESULTS: Results indicated that the PM intervention increased brain responsivity in left posterior insula in response to negative affective stimuli, and altered resting state functional connectivity in regions involved in self-reference, behavioral regulation, and social-emotional processing. Changes in mothers' brain function and connectivity were associated with increased mindful parenting and decreased emotional reactivity to the parent-adolescent conflict task. CONCLUSIONS: Findings suggest that mindfulness-based changes in maternal emotional awareness at the neurobiological level are associated with decreased emotional reactivity in parenting interactions, illuminating potential neurobiological targets for future parent-focused intervention.

Parenting-focused mindfulness intervention reduces stress and improves parenting in highly-stressed mothers of adolescents.

Parent stress has been associated with negative outcomes for youth and may be particularly high during adolescence. Mindfulness interventions have the potential to reduce parent stress and to improve parenting behavior and parent-child relationship quality. The present randomized controlled study examined effects of a parenting-focused mindfulness intervention, the Parenting Mindfully (PM) intervention, for highly stressed parents of adolescents. Eighty three mothers of 12-17 year olds reporting high stress were randomly assigned to the PM intervention or to a minimal-intervention Parent Education (PE) control group. At pre- and post-intervention, mothers reported on their mindfulness, stress, parenting stress, mindful parenting, and parent-adolescent relationship quality. At pre- and post-intervention, mothers' observed parenting behaviors and reported negative emotional responses to a laboratory parent-adolescent interaction task (PAIT) were also collected. Findings indicated that the PM intervention, compared to PE, increased mothers' mindfulness, reduced parenting stress in two domains, increased mindful parenting related to emotional awareness in parenting, and improved parent-adolescent relationship quality. For mothers of girls (but not mothers of boys), the PM intervention also decreased negative parenting behavior and decreased negative emotional responses in PAIT. Effects sizes were medium to large. In sum, findings support parenting-focused mindfulness training as a viable intervention strategy for highly-stressed parents.

Neural activation to loss and reward among alcohol naive adolescents who later initiate alcohol use.

Adolescent alcohol use is associated with adverse psychosocial outcomes, including an increased risk of alcohol use disorder in adulthood. It is therefore important to identify risk factors of alcohol initiation in adolescence. Research to date has shown that altered neural activation to reward is associated with alcohol use in adolescence; however, few studies have focused on neural activation to loss and alcohol use. The current study examined neural activation to loss and reward among 64 alcohol naive 12-14 year olds that did (n = 20) and did not initiate alcohol use by a three year follow-up period. Results showed that compared to adolescents that did not initiate alcohol use, adolescents that did initiate alcohol use by the three year follow-up period had increased activation to loss in the left striatum (i.e., putamen), right precuneus, and the brainstem/pons when they were alcohol naive at baseline. By contrast, alcohol initiation was not associated with neural activation to winning a reward. These results suggest that increased activation in brain regions implicated in salience, error detection/self-referential processing, and sensorimotor function, especially to negative outcomes, may represent an initial vulnerability factor for alcohol use in adolescence.

Effects of A Parenting-Focused Mindfulness Intervention on Adolescent Substance Use and Psychopathology: A Randomized Controlled Trial.

Substance use and psychopathology symptoms increase in adolescence. One key risk factor for these is high parent stress. Mindfulness interventions reduce stress in adults and may be useful to reduce parent stress and prevent substance use (SU) and psychopathology in adolescents. This study tested the feasibility and effects of a mindfulness intervention for parents on adolescent SU and psychopathology symptoms. Ninety-six mothers of 11-17 year olds were randomly assigned to a mindfulness intervention for parents (the Parenting Mindfully [PM] intervention) or a brief parent education [PE] control group. At pre-intervention, post-intervention, 6-month follow-up, and 1-year follow-up, adolescents reported on SU and mothers and adolescents reported on adolescent externalizing and internalizing symptoms. Primary intent to treat analyses found that the PM intervention prevented increases in adolescent SU over time, relative to the PE control group. The PM intervention also prevented increases in mother-reported externalizing symptoms over time relative to the PE control group. However, PM did not have a significant effect on internalizing symptoms. PM had an indirect effect on adolescent-reported externalizing symptoms through greater mother mindfulness levels at post-intervention, suggesting mother mindfulness as a potential intervention mechanism. Notably, while mothers reported high satisfaction with PM, intervention attendance was low (31% of mothers attended zero sessions). Secondary analyses with mothers who attended > = 50% of the interventions (n = 48) found significant PM effects on externalizing symptoms, but not SU. Overall, findings support mindfulness training for parents as a promising intervention and future studies should work to promote accessibility for stressed parents.Clinical Trials Identifier: NCT02038231; Date of Registration: January 13, 2014.

Neural Underpinnings of Social Contextual Influences on Adolescent Risk-Taking.

Purpose of review: Adolescence is a developmental period often characterized by heightened risk taking and increased sensitivity to socially salient stimuli. In this report, we discuss how the developing brain serves as both a link between, and a susceptibility factor for, social contextual factors and risk taking in adolescence. Recent findings: Neural activity in regions related to affective processing, cognitive control, and social cognition, which continue to develop across the adolescent years, shape the relationship between adolescents' social environment and their risk taking. Summary: Examining neural patterns of adolescent brain development enriches our understanding of how adolescents' complex social environment modulates their risk-taking behavior, which may have implications for adolescents' current and future substance use.

Adolescent Brain Response to Reward Is Associated with a Bias toward Immediate Reward.

The current study examines associations between neural activation to the receipt of monetary reward in a rewarding game task and bias toward immediate reward measured in a behavioral delay discounting task among early adolescents (N = 58, 12-14 years). As expected, heightened brain activation in reward-related regions were correlated with higher bias toward immediate reward. This suggests that bias toward immediate reward in delay discounting tasks may be linked to heightened activation to reward in reward processing regions. This interplay between neural reward processing and bias toward immediate reward might explain the sharp increases in bias toward immediate reward that occur in early adolescence.

Maternal Emotional and Physiological Reactivity: Implications for Parenting and the Parenting-Adolescent Relationship.

OBJECTIVE: Parent physiology and emotion may play an important role in parenting and parent-child relationship quality, yet little research has examined these associations in parents of adolescents. This study employed a naturalistic laboratory-based approach to observe maternal reactivity (mothers' cardiovascular and negative emotional responses) during a parent-adolescent interaction task (PAIT) and associations with parenting behavior and parent-adolescent relationship quality. We also examined possible indirect effect of maternal reactivity on parent-adolescent relationship quality through parenting variables. METHODS: Mothers (n = 196) of 12-14 year olds completed the PAIT, a 10-minute laboratory task in which mothers and adolescents discussed a family conflict topic. Mother-rated negative emotional experience, mother heart rate (HR), and systolic and diastolic blood pressure (BP) responses to PAIT were collected. Additionally, observed maladaptive and positive parenting during PAIT and reported parent-adolescent relationship quality were collected. RESULTS: We found that mothers' heightened negative emotional experience in PAIT was associated with heightened observed and reported maladaptive parenting and lower parent-adolescent relationship quality (p<.001). Additionally, blunted HR reactivity was related to higher positive parenting in PAIT (p<.05). Lastly, we found an indirect effect of HR on parent-adolescent relationship through positive parenting and an indirect effect of maternal negative emotional experience on parent-adolescent relationship quality through maladaptive and positive parenting. In sum, high emotional reactivity and blunted HR predicted poorer parenting, and directly and indirectly affected parent-adolescent relationship quality. CONCLUSIONS: Parent reactivity may be important to consider in interventions.

Sex-Differentiated Associations among Negative Parenting, Emotion-Related Brain Function, and Adolescent Substance Use and Psychopathology Symptoms.

Parenting is a critical factor in adolescent social-emotional development, with maladaptive parenting leading to risk for the development of psychopathology. However, the emotion-related brain mechanisms underlying the influence of parenting on psychopathology symptoms are unknown. The present study utilized functional magnetic resonance imaging and laboratory measures to examine sex-differentiated associations among parenting, adolescent emotion-related brain function, and substance use and psychopathology symptoms in 66 12-14 year olds. Maternal parenting behaviors (warmth, negative parenting) were observed in a laboratory task. Adolescent brain responses to negative emotional stimuli were assessed in emotion processing regions of interest (left [L] and right [R] amygdala, anterior insula, anterior cingulate cortex [ACC]). Adolescents reported on substance use and depressive, anxiety, and externalizing symptoms. Maternal negative parenting predicted adolescent brain activation differently by sex. For girls, negative parenting predicted heightened R ACC activation to negative emotional stimuli. For boys, negative parenting predicted blunted L and R anterior insula and L ACC activation. Furthermore, for girls, but not boys, heightened L anterior insula and heightened L and R ACC activation were associated with substance use and depressive symptoms, respectively. Findings suggest neural response to negative emotion as a possible sex-specific pathway from negative parenting to psychopathology.

Associations Between Parent Emotional Arousal and Regulation and Adolescents' Affective Brain Response.

Parents' emotional functioning represents a central mechanism in the caregiving environment's influence on adolescent affective brain function. However, a paucity of research has examined links between parental emotional arousal and regulation and adolescents' affective brain function. Thus, the present study examined associations between parents' self-rated negative emotion, parent emotion regulation difficulties, and adolescent brain responsivity to negative and positive emotional stimuli. Participants included 64 12-14 year-old adolescents (31 females) and their female primary caregivers. Adolescents viewed negative, positive, and neutral emotional stimuli during an fMRI scanning session. Region of interest analyses showed that higher parent negative emotion was related to adolescents' greater ACC and vmPFC response to both negatively- and positively-valenced emotional stimuli; whereas, parent negative emotion was related to adolescents' greater amygdala response to negative emotional stimuli only. Furthermore, parent emotion regulation moderated the association between parent negative emotion and adolescents' brain response to negative emotional stimuli, such that parents with high negative emotion and high emotion regulation difficulties had adolescents with the greatest affective brain response. Findings highlight the importance of considering both parent emotional arousal and regulation in understanding the family affective environment and its relation to adolescent emotion-related brain development.

Mindful Parenting and Parents' Emotion Expression: Effects on Adolescent Risk Behaviors.

Mindful parenting is associated with greater adjustment and fewer behavior problems in children and adolescents. However, the mechanisms by which mindful parenting functions to mitigate risk in adolescence is not well understood. This study investigated parent emotional expression as a potential mechanism in the relationship between low mindful parenting and adolescent risk behaviors. A sample of 157 12-14 year old adolescents (49% female) and their primary caregivers (99% female) participated in an emotionally-arousing conflict interaction. Parents reported on their mindful parenting practices, and parents' emotion expressions during the conflict interaction were coded including negative emotion, positive emotion, and shared parent-youth positive emotion. Adolescent substance use and sex behaviors were assessed through self-report, interview, and physical toxicology screens. Results indicated that mindful parenting was associated with less parental negative emotion and greater shared positive emotion during the parent-adolescent conflict. Further, results revealed a significant indirect effect of mindful parenting on youth's substance use through shared parent-adolescent positive emotion. Findings highlight the relevance of emotional functioning in the context of stressful parenting situations in mindful parenting.

Adolescent Substance Use & Psychopathology: Interactive Effects of Cortisol Reactivity and Emotion Regulation.

How are emotional processes associated with the increased rates of substance use and psychological disorders commonly observed during adolescence? An index of emotion-related physiological arousal-cortisol reactivity-and subjective emotion regulation have both been independently linked to substance use and psychological difficulties among youth. The current study (N = 134 adolescents) sought to elucidate the interactive effects of cortisol reactivity following a stressful parent-child interaction task and self-reported emotion regulation ability on adolescents' substance use and externalizing and internalizing behavior problems. Results revealed that adolescents with low levels of cortisol reactivity and high emotion regulation difficulties were more likely to use substances, and also had the highest parent-reported symptoms of oppositional defiant disorder. With respect to internalizing symptoms, high emotion-related physiological reactivity coupled with high emotion regulation difficulties were associated with higher self-reported major depression symptoms among youth. Findings reveal that different profiles of HPA axis arousal and emotion regulation are associated with substance use and symptoms of psychopathology among adolescents.