Detalhe da pesquisa
1.
Higher oral efficacy of ravuconazole in self-nanoemulsifying systems in shorter treatment in experimental chagas disease.
Exp Parasitol
; 228: 108142, 2021 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-34375652
2.
In vitro antileishmanial activity of ravuconazole, a triazole antifungal drug, as a potential treatment for leishmaniasis.
J Antimicrob Chemother
; 73(9): 2360-2373, 2018 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29982734
3.
Squalene synthase as a target for Chagas disease therapeutics.
PLoS Pathog
; 10(5): e1004114, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24789335
4.
SQ109, a new drug lead for Chagas disease.
Antimicrob Agents Chemother
; 59(4): 1950-61, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25583723
5.
Recent clinical trials for the etiological treatment of chronic chagas disease: advances, challenges and perspectives.
J Eukaryot Microbiol
; 62(1): 149-56, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25284065
6.
Benznidazole for Chronic Chagas' Cardiomyopathy.
N Engl J Med
; 374(2): 189, 2016 01 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26760095
7.
The effect of 3-(biphenyl-4-yl)-3-hydoxyquinuclidine (BPQ-OH) and metronidazole on Trichomonas vaginalis: a comparative study.
Parasitol Res
; 113(6): 2185-97, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24752367
8.
Amiodarone inhibits Trypanosoma cruzi infection and promotes cardiac cell recovery with gap junction and cytoskeleton reassembly in vitro.
Antimicrob Agents Chemother
; 55(1): 203-10, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21078932
9.
Synthetic arylquinuclidine derivatives exhibit antifungal activity against Candida albicans, Candida tropicalis and Candida parapsilopsis.
Ann Clin Microbiol Antimicrob
; 10: 3, 2011 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-21255433
10.
Two squalene synthase inhibitors, E5700 and ER-119884, interfere with cellular proliferation and induce ultrastructural and lipid profile alterations in a Candida tropicalis strain resistant to fluconazole, itraconazole, and amphotericin B.
J Infect Chemother
; 17(4): 563-70, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21264486
11.
New chemotherapy regimens and biomarkers for Chagas disease: the rationale and design of the TESEO study, an open-label, randomised, prospective, phase-2 clinical trial in the Plurinational State of Bolivia.
BMJ Open
; 11(12): e052897, 2021 12 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-34972765
12.
Drug Susceptibility of Genetically Engineered Trypanosoma cruzi Strains and Sterile Cure in Animal Models as a Criterion for Potential Clinical Efficacy of Anti-T. cruzi Drugs.
Antimicrob Agents Chemother
; 59(12): 7923-4, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26578701
13.
Effect of Posaconazole in an in vitro model of cardiac fibrosis induced by Trypanosoma cruzi.
Mol Biochem Parasitol
; 238: 111283, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32564978
14.
Emerging agents for the treatment of Chagas disease: what is in the preclinical and clinical development pipeline?
Expert Opin Investig Drugs
; 29(9): 947-959, 2020 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-32635780
15.
Absence of CD4+ T lymphocytes, CD8+ T lymphocytes, or B lymphocytes has different effects on the efficacy of posaconazole and benznidazole in treatment of experimental acute Trypanosoma cruzi infection.
Antimicrob Agents Chemother
; 53(1): 174-9, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19001113
16.
Altered sterol profile induced in Leishmania amazonensis by a natural dihydroxymethoxylated chalcone.
J Antimicrob Chemother
; 63(3): 469-72, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19176591
17.
Growth inhibition and ultrastructural alterations induced by Delta24(25)-sterol methyltransferase inhibitors in Candida spp. isolates, including non-albicans organisms.
BMC Microbiol
; 9: 74, 2009 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-19379501
18.
Ergosterol biosynthesis and drug development for Chagas disease.
Mem Inst Oswaldo Cruz
; 104 Suppl 1: 311-8, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19753490
19.
Venezuela's humanitarian crisis, resurgence of vector-borne diseases, and implications for spillover in the region.
Lancet Infect Dis
; 19(5): e149-e161, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30799251
20.
In vitro activities of ER-119884 and E5700, two potent squalene synthase inhibitors, against Leishmania amazonensis: antiproliferative, biochemical, and ultrastructural effects.
Antimicrob Agents Chemother
; 52(11): 4098-114, 2008 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-18765694