1.
Bioorg Med Chem
; 11(7): 1531-50, 2003 Apr 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12628677
RESUMO
The synthesis, in vitro antifungal evaluation and SAR studies of 101 compounds of the 4-aryl-, 4-alkyl-, 4-pyridyl or -quinolinyl-4-N-arylamino-1-butenes series and related compounds, are reported here. Active structures showed to inhibit (1,3)-beta-D-glucan and mainly chitin synthases, enzymes that catalyze the synthesis of the major fungal cell wall polymers.