[Pathogenetic aspects of early stages of hypertension and possibilities of non-drug treatment]. / Patogeneticheskie osobennosti nachal'nykh stadii gipertonicheskoi bolezni i vozmozhnosti nelekarstvennoi terapii.

A comprehensive study of young patients with early hypertensive disease (HD) has revealed their constitutional personality traits which result at long-term traumatization (in addition to exogenous stresses, there is an intrapersonal conflict) in the autonomic nervous disintegration syndrome, lowered parasympathetic effects in the presence of hypersympathicotonia. There is markedly impaired secretion in the dopaminergic link of the sympathoadrenal system along with a steady-state increase in norepinephrine:dopamine ratio, which may be regarded as a possible marker (a risk factor) of HD progression. The decreased secretion of the antistressors dopamine and beta-endorphin can also make a contribution to the progression of HD and its evolution.

[The therapeutic efficacy of pyrazidol in depressive states]. / Terapevticheskaia éffektivnost' pirazidola pri depressivnykh sostoianiiakh

A total of 125 depressive patients were treated by pyrasidol. It was depicted that this drug is an antidepressant with a marked tranquillizing component activity. It does not cause complications and marked side-effects. Its use is more effective in an anxiety-depressive syndrome, within manic-depressive psychosis, vascular and organic damages of the CNS, somatogenic and reactive depressions. Pyrasidol can also be used in the treatment of depressive patients of the elderly, somatic patients and physically weaked ones.