Detalhe da pesquisa
1.
Illuminating G-Protein-Coupling Selectivity of GPCRs.
Cell
; 177(7): 1933-1947.e25, 2019 06 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31160049
2.
Emerging roles of lysophosphatidylserine as an immune modulator.
Immunol Rev
; 317(1): 20-29, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37036835
3.
Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA6.
Nature
; 548(7667): 356-360, 2017 08 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-28792932
4.
Isosteric Replacement of Ester Linkage of Lysophospholipids with Heteroaromatic Rings Retains Potency and Subtype Selectivity.
Chem Pharm Bull (Tokyo)
; 71(7): 584-615, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37394607
5.
Membrane Phospholipid Analogues as Molecular Rulers to Probe the Position of the Hydrophobic Contact Point of Lysophospholipid Ligands on the Surface of G-Protein-Coupled Receptor during Membrane Approach.
Biochemistry
; 59(11): 1173-1201, 2020 03 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32124599
6.
Novel lysophosphoplipid receptors: their structure and function.
J Lipid Res
; 55(10): 1986-95, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-24891334
7.
Structural basis for lysophosphatidylserine recognition by GPR34.
Nat Commun
; 15(1): 902, 2024 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38326347
8.
Synthesis and Biological Evaluation of Lysophosphatidic Acid Analogues Using Conformational Restriction and Bioisosteric Replacement Strategies.
ACS Omega
; 8(51): 49278-49288, 2023 Dec 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-38162765
9.
Ectodomain shedding of EGFR ligands serves as an activation readout for TRP channels.
PLoS One
; 18(1): e0280448, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36668668
10.
Exploration of LPS2 agonist binding modes using the combination of a new hydrophobic scaffold and homology modeling.
Eur J Med Chem
; 252: 115271, 2023 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36965226
11.
Medium-chain fatty acids suppress lipotoxicity-induced hepatic fibrosis via the immunomodulating receptor GPR84.
JCI Insight
; 8(2)2023 Jan 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-36480287
12.
Dietary Lactobacillus-Derived Exopolysaccharide Enhances Immune-Checkpoint Blockade Therapy.
Cancer Discov
; 12(5): 1336-1355, 2022 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35180303
13.
Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases in mice and cynomolgus macaques.
Mucosal Immunol
; 15(2): 289-300, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35013573
14.
Switching Lysophosphatidylserine G Protein-Coupled Receptor Agonists to Antagonists by Acylation of the Hydrophilic Serine Amine.
J Med Chem
; 64(14): 10059-10101, 2021 07 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34233115
15.
2-Carba-lysophosphatidic acid is a novel ß-lysophosphatidic acid analogue with high potential for lysophosphatidic acid receptor activation and autotaxin inhibition.
Sci Rep
; 11(1): 17360, 2021 08 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-34462512
16.
Non-naturally Occurring Regio Isomer of Lysophosphatidylserine Exhibits Potent Agonistic Activity toward G Protein-Coupled Receptors.
J Med Chem
; 63(17): 9990-10029, 2020 09 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32787112
17.
Probing the Hydrophobic Binding Pocket of G-Protein-Coupled Lysophosphatidylserine Receptor GPR34/LPS1 by Docking-Aided Structure-Activity Analysis.
J Med Chem
; 60(14): 6384-6399, 2017 07 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-28715213
18.
Conformational Constraint of the Glycerol Moiety of Lysophosphatidylserine Affords Compounds with Receptor Subtype Selectivity.
J Med Chem
; 59(8): 3750-76, 2016 04 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-27077565
19.
Lysophosphatidylserine analogues differentially activate three LysoPS receptors.
J Biochem
; 157(3): 151-60, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25320102
20.
Structure-activity relationships of lysophosphatidylserine analogs as agonists of G-protein-coupled receptors GPR34, P2Y10, and GPR174.
J Med Chem
; 58(10): 4204-19, 2015 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-25970039