Detalhe da pesquisa
1.
Design and optimization of a series of 4-(3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-2-amines: Dual inhibitors of TYK2 and JAK1.
Bioorg Med Chem
; 28(10): 115481, 2020 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32253095
2.
Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase.
Bioorg Med Chem Lett
; 25(22): 5352-6, 2015 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26411795
3.
Discovery and synthesis of novel 4-aminopyrrolopyrimidine Tie-2 kinase inhibitors for the treatment of solid tumors.
Bioorg Med Chem Lett
; 23(10): 3059-63, 2013 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23566514
4.
Macrocyclic Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonists.
ACS Med Chem Lett
; 14(2): 191-198, 2023 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36793423
5.
Deconstruction of activity-dependent covalent modification of heme in human neutrophil myeloperoxidase by multistage mass spectrometry (MS(4)).
Biochemistry
; 51(10): 2065-77, 2012 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-22352991
6.
Structure-guided inhibitor design for human acetyl-coenzyme A carboxylase by interspecies active site conversion.
J Biol Chem
; 286(48): 41510-41519, 2011 Dec 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-21953464
7.
Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex.
Cancer Cell
; 5(4): 317-28, 2004 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-15093539
8.
Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1.
J Med Chem
; 65(1): 757-784, 2022 01 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34967602
9.
Demonstration of In Vitro to In Vivo Translation of a TYK2 Inhibitor That Shows Cross Species Potency Differences.
Sci Rep
; 10(1): 8974, 2020 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32488071
10.
Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases.
J Med Chem
; 63(22): 13561-13577, 2020 11 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32787094
11.
Discovery of Potent and Selective Periphery-Restricted Quinazoline Inhibitors of the Cyclic Nucleotide Phosphodiesterase PDE1.
J Med Chem
; 61(10): 4635-4640, 2018 05 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-29718668
12.
Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841).
J Med Chem
; 61(19): 8597-8612, 2018 10 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30113844
13.
The 2.0 A crystal structure of the ERalpha ligand-binding domain complexed with lasofoxifene.
Protein Sci
; 16(5): 897-905, 2007 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-17456742
14.
Suppressor of fused regulates Gli activity through a dual binding mechanism.
Mol Cell Biol
; 24(19): 8627-41, 2004 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-15367681
15.
Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition.
ACS Chem Biol
; 11(12): 3442-3451, 2016 12 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-27791347
16.
Comprehensive functional maps of the antigen-binding site of an anti-ErbB2 antibody obtained with shotgun scanning mutagenesis.
J Mol Biol
; 320(2): 415-28, 2002 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-12079396
17.
Decreasing the rate of metabolic ketone reduction in the discovery of a clinical acetyl-CoA carboxylase inhibitor for the treatment of diabetes.
J Med Chem
; 57(24): 10512-26, 2014 Dec 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25423286
18.
Discovery and optimization of a novel spiropyrrolidine inhibitor of ß-secretase (BACE1) through fragment-based drug design.
J Med Chem
; 55(21): 9069-88, 2012 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22468999
19.
Structural insights into the catalytic mechanism of cyclophilin A.
Nat Struct Biol
; 10(6): 475-81, 2003 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-12730686