Detalhe da pesquisa
1.
Resistance Analyses in Highly Treatment-Experienced People With Human Immunodeficiency Virus (HIV) Treated With the Novel Capsid HIV Inhibitor Lenacapavir.
J Infect Dis
; 226(11): 1985-1991, 2022 11 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36082606
2.
Phenotypic resistance to lenacapavir and monotherapy efficacy in a proof-of-concept clinical study.
J Antimicrob Chemother
; 77(4): 989-995, 2022 03 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-35028668
3.
Preclinical Assessment of the Analgesic Pharmacology of NKTR-181 in Rodents.
Cell Mol Neurobiol
; 41(5): 949-960, 2021 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-32107752
4.
HIV-1 envelope diversity and sensitivity to broadly neutralizing antibodies across stages of acute HIV-1 infection.
AIDS
; 38(4): 607-610, 2024 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38416554
5.
Safety of teropavimab and zinlirvimab with lenacapavir once every 6 months for HIV treatment: a phase 1b, randomised, proof-of-concept study.
Lancet HIV
; 11(3): e146-e155, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38307098
6.
Long-acting lenacapavir acts as an effective preexposure prophylaxis in a rectal SHIV challenge macaque model.
J Clin Invest
; 133(16)2023 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37384413
7.
Lenacapavir administered every 26 weeks or daily in combination with oral daily antiretroviral therapy for initial treatment of HIV: a randomised, open-label, active-controlled, phase 2 trial.
Lancet HIV
; 10(1): e15-e23, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36566079
8.
In vivo and in vitro Characterization of a Partial Mu Opioid Receptor Agonist, NKTR-181, Supports Future Therapeutic Development.
Front Pain Res (Lausanne)
; 2: 695962, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-35295409
9.
NKTR-358: A novel regulatory T-cell stimulator that selectively stimulates expansion and suppressive function of regulatory T cells for the treatment of autoimmune and inflammatory diseases.
J Transl Autoimmun
; 4: 100103, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34041473
10.
Formation of DNA-protein cross-links between gamma-hydroxypropanodeoxyguanosine and EcoRI.
Chem Res Toxicol
; 21(9): 1733-8, 2008 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-18690724
11.
NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models.
Clin Cancer Res
; 22(3): 680-90, 2016 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26832745
12.
Differential DNA recognition and cleavage by EcoRI dependent on the dynamic equilibrium between the two forms of the malondialdehyde-deoxyguanosine adduct.
Biochemistry
; 44(13): 5024-33, 2005 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-15794640
13.
Induction of frameshift and base pair substitution mutations by the major DNA adduct of the endogenous carcinogen malondialdehyde.
Proc Natl Acad Sci U S A
; 100(24): 14247-52, 2003 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-14603032