[Chronic degenerative conditions as risk factors for lethal COVID-19Doenças crônicas degenerativas como fator de risco para letalidade por COVID-19]. / Enfermedades crónicas degenerativas como factor de riesgo de letalidad por COVID-19 en México.

Objective: To determine the relative risk of a lethal outcome associated with chronic degenerative conditions in patients with COVID-19. Methods: A cohort study was conducted using electronic medical records belonging to patients who tested positive for COVID-19 on RT-PCR while receiving care as outpatients or inpatients in a social security system facility between March 2020 and March 2021. Two study groups were formed. The exposed group was divided into four subgroups, each of which was diagnosed with one and only one chronic condition (diabetes, hypertension, obesity, or chronic kidney disease); the unexposed group was obtained from the medical records of patients without comorbidities. A total of 1 114 medical records were examined using simple random sampling. Once the minimum sample size was reached, the relative risk was calculated for each chronic condition. Combinations of two, three, and four conditions were created, and each of them was included in the analysis. Results: In the absence of a chronic degenerative condition, the prevalence of a lethal outcome from COVID-19 is 3.8%; in the presence of type 2 diabetes mellitus, 15.8%; in the presence of arterial hypertension, 15.6%; and in the presence of obesity, 15.0%. For diabetes and hypertension combined, the prevalence of a lethal outcome is 54.1%; for diabetes and obesity combined, 36.8%, and for obesity and hypertension combined, 28.1%. Conclusion: In patients with COVID-19, the relative risk of a lethal outcome is 4.17 for those with diabetes, 4.13 for those with hypertension, and 3.96 for those with obesity. For two chronic conditions combined, the relative risk doubles or triples. The relative risk of a lethal outcome is 14.27 for diabetes plus hypertension; 9.73 for diabetes plus obesity, and 7.43 for obesity plus hypertension. Chronic conditions do not present alone; they generally occur together, hence the significance of the relative risks for lethal outcomes presented in this paper.

Objetivo: Determinar o risco de letalidade conferido por doenças crônicas degenerativas em pacientes com COVID-19. Métodos: Foi realizado um estudo de coorte em prontuários eletrônicos de pacientes com RT-PCR positivo para COVID-19 em atendimento ambulatorial ou hospitalar em uma instituição de previdência social, no período de março de 2020 a março de 2021. Foram constituídos dois grupos de estudo. O grupo exposto foi dividido em quatro subgrupos, cada um com diagnóstico único e exclusivo de uma doença crônica (diabetes, hipertensão, obesidade ou doença renal crônica). O grupo não exposto foi constituído por prontuários de pacientes sem comorbidades. Foram revisados 1.114 prontuários no total, utilizando técnica de amostragem aleatória simples. Uma vez obtido o tamanho mínimo da amostra, foi calculado o risco relativo para cada doença crônica. Foram realizadas combinações de 2, 3 e 4, tendo sido feita a análise com cada uma delas. Resultados: Na ausência de doença crônica degenerativa, a prevalência de letalidade na COVID-19 é de 3,8%; na presença de diabetes mellitus tipo 2, a letalidade é de 15,8%; na presença de hipertensão arterial, 15,6%; e na presença de obesidade, 15%. Quando tanto diabetes como hipertensão estão presentes, a letalidade é de 54,1%; com diabetes e obesidade, 36,8%; e obesidade com hipertensão, 28,1%. Conclusões: Em pacientes com COVID-19, o risco relativo de letalidade é de 4,17 naqueles com diabetes; 4,13 naqueles com hipertensão; e 3,96 naqueles com obesidade. Quando duas doenças crônicas são combinadas, o risco relativo dobra ou triplica. Para diabetes e hipertensão, o risco relativo de letalidade é 14,27; para diabetes e obesidade, 9,73; e para obesidade e hipertensão, 7,43. As doenças crônicas não ocorrem sozinhas (geralmente estão associadas), e nessa perspectiva os riscos relativos de letalidade apresentados neste artigo tornam-se relevantes.

[Health status of the elderly in primary health care practices using an integral geriatric assessment]. / Estado de salud en el adulto mayor en atención primaria a partir de una valoración geriátrica integral.

OBJECTIVE: To determine the health status of patients 60 years of age or over in Primary Health Care practices using an integral geriatric assessment. DESIGN: Descriptive cross-sectional study. LOCATION: Five primary care units, Instituto Mexicano del Seguro Social; México. PARTICIPANTS: Elderly patient aged 60 years of age or over, who were seen in primary health care practices. Previously signed informed consent was given, with exclusion criteria being non-completion of the integral geriatric assessment. A technical sample of conglomerates and quota was used. MAIN MEASUREMENTS: Medical dimension variables: visual, hearing (Hearing Handicap Inventory for the Elderly), urinary incontinence (Consultation in Incontinence Questionnaire), nutritional condition (Mini Nutritional Assessment), personal clinical history, polypharmacy; mental impairment (Mini Mental State Examination), depression (Yesavaje); functional: basic (Katz) and instrumental (Lawton and Brody) activities of daily living, mobility (Up and go) and social (Social sources scale). The analysis included percentages and confidence intervals. RESULTS: In the medical dimensions; 42.3% with visual impairment, 27.7% hearing, 68.3% urinary incontinence, 37.0% malnutrition, and 54.7% polypharmacy. In the mental dimension: 4.0% severe mental impairment, and 11% depression: functional dimension: 2.0% total dependence of activities of daily living; 14.3% instrumental activities impairment; 29.0% mobility impairment, and 48.0% had moderately deteriorated social resources. CONCLUSION: The health status of the elderly seen in primary health care practices is characterized by independent patients with different levels of alterations in the medical dimensions, low levels in mental alteration, and moderately deteriorated social resources.

[Natural history of breast cancer diagnostic procedures]. / Historia natural del proceso diagnóstico del cáncer de mama.

OBJECTIVE: To build a model that explains the natural history of breast cancer diagnostic procedures. METHODS: Descriptive cross-sectional study of 245 women between 40 and 69 years of age, selected by simple random sampling, who underwent a mammography and met the requirements of the breast cancer diagnostic procedure. Diagnosis was made by biopsy. For the diagnostic procedure, an estimate was made of the percentage of patients seen by each service, the total number of patients per service, and the total number of consultations in each service, with 95% confidence intervals. RESULTS: Of the patients who initiated the breast cancer diagnostic procedure in preventive medicine services, 20% underwent a mammography; 23.7% were seen in family medicine services and of these patients, 70.9% were referred to a breast clinic, where 7.3% underwent a harpoon biopsy. The prevalence of breast cancer confirmed by biopsy was 0.48% (95%CI: 0.0-1.3). Per 1 000 patients who initiated the procedure, 47.4 were seen in family medicine services and 33.6 in a breast clinic, and open biopsies were performed on 2.4. Per 1 000 patients who initiated the procedure, there were 211.4 consultations in radiology services, 51.6 in family medicine services, and 54.6 in a breast clinic. CONCLUSIONS: The model described here may be useful in planning and evaluation activities.

[Epidemiological profile of rheumatoid arthritis]. / Perfil epidemiológico de la artritis reumatoide.

Background: Rheumatoid arthritis affects approximately between 0.3 and 1.2% of the world population. In Latin America, different studies have estimated a prevalence between 0.2 and 0.5% in the population over 16 years of age. Objective: To identify the epidemiological profile of rheumatoid arthritis. Material and methods: Descriptive cross-sectional design carried out in an urban population of a social security institution in Mexico. The information of the clinical file of 373 patients was studied. The epidemiological profile included the sociodemographic dimension, family history, health, clinical, therapeutic, biochemical, extra-articular manifestations and complications. Statistical analysis percentages, means, confidence intervals for percentages and confidence intervals for averages were calculated. Results: The wrists were the most affected joints with 44.6% (95% CI: 39.5-49.6%). The extra-articular manifestation with the highest prevalence was asthenia with 9.9% (95% CI: 6.9-12.9%); predominant diagnosis according to ICD-10 was seropositive rheumatoid arthritis with 59.8% (95% CI: 54.8-64.8%), and the rheumatoid factor was highly positive in 78.3% (95% CI: 74.1-82.5%); predominant treatment was with combined therapy at diagnosis in 97.6% (95% CI: 96.0-99.1%). The duration of treatment was > 10 years in 34.1% (95% CI: 29.2-38.8%). Conclusion: This work has described the epidemiological profile of the patient with rheumatoid arthritis in different dimensions.

Introducción: la artritis reumatoide afecta aproximadamente entre 0.3 y 1.2% de la población mundial. En Latinoamérica diferentes estudios han estimado una prevalencia entre 0.2 y 0.5% en población mayor de 16 años de edad. Objetivo: identificar el perfil epidemiológico de la artritis reumatoide. Material y métodos: diseño transversal descriptivo llevado a cabo en población urbana de una institución de seguridad social en México. Se estudió la información del expediente clínico de 373 pacientes. El perfil epidemiológico incluyó la dimensión sociodemográfica, antecedentes heredofamiliares, de salud, clínicos, terapéuticos, bioquímicos, de manifestaciones extraarticulares y de complicaciones. Se calcularon porcentajes, promedios, e intervalos de confianza para porcentajes y promedios. Resultados: las muñecas fueron las articulaciones más afectadas con 44.6% (IC 95%: 39.5-49.6%). La manifestación extraarticular con más alta prevalencia fue la astenia con 9.9% (IC 95%: 6.9-12.9%); el diagnóstico predominante de acuerdo con el CIE-10 fue la artritis reumatoide seropositiva con 59.8% (IC 95%: 54.8-64.8%) y se encontró el factor reumatoide positivo alto en un 78.3% (IC 95%: 74.1%-82.5%); el tratamiento predominante fue con terapia combinada al diagnóstico en un 97.6%, (IC 95%: 96.0-99.1%). La duración del tratamiento fue > 10 años en el 34.1% (IC 95%: 29.2-38.8%). Conclusión: este trabajo ha descrito el perfil epidemiológico del paciente con artritis reumatoide en diferentes dimensiones.

[Incidence of COVID-19 in health workers. Work activity and home protection]. / Incidencia de COVID-19 en trabajadores de salud. Actividad laboral y resguardo domiciliario.

Background: The COVID-19 pandemic has had repercussions in the social, economic, psychological and health spheres, for which risk and exposure groups have been identified. Health workers are distinguished from the rest of the population by constant contact with patients carrying the SARS-CoV-2 virus. Objetive: To determine the difference in the incidence of COVID-19 in health workers who remain in work activity and those who shelter at home. Material and methods: Cohort study in health workers from March 2020 to January 2021. Two groups were integrated, the exposed group made up of workers who remained working in the health unit (n = 4650) and the non-exposed group, those who carried out home protection (n = 337). When the groups were integrated, none had a diagnosis of COVID-19, they were followed up for 11 months and when COVID-19 was diagnosed, it was done with a PCR test. Statistical analysis included incidence rate, confidence intervals, Chi square, relative risk, and confidence interval for relative risk. Results: The incidence of COVID-19 in workers in home shelter was 39.8% (95% CI: 34.6-45.0) and in workers who remained in the medical unit 16.0% (95% CI: 14.9-17.1). The relative risk was 0.40 (95% CI: 0.34-0.47) for workers who remained working in the health unit. Conclusion: The incidence of COVID-19 was higher in health workers with home protection than in those who continued with normal activities in the medical unit.

Introducción: la pandemia por COVID-19 ha repercutido en el ámbito social, económico, psicológico y de la salud, por lo que se han identificado grupos de riesgo y de exposición. Los trabajadores de la salud se distinguen del resto de la población por el contacto constante con pacientes portadores del virus SARS-CoV-2. Objetivo: determinar la diferencia de incidencia de COVID-19 en trabajadores de la salud que permanece en actividad laboral y los que se resguardan en domicilio. Material y métodos: estudio de cohorte en trabajadores de la salud de marzo 2020 a enero 2021. Se integraron dos grupos: el grupo expuesto compuesto por trabajadores que permanecieron laborando en la unidad de salud (n = 4650) y el grupo no expuesto, que realizaron resguardo domiciliario (n = 337). Cuando se integraron los grupos ninguno tenía diagnóstico de COVID-19, se siguieron durante 11 meses y cuando se diagnosticó COVID-19 se realizó con prueba de PCR. El análisis estadístico incluyó tasa de incidencia, Intervalos de confianza, Chi cuadrada, riesgo relativo e intervalo de confianza para riesgo relativo. Resultados: la incidencia de COVID-19 de trabajadores en resguardo domiciliario fue de 39.8% (IC95%: 34.6-45.0) y en trabajadores que permanecieron en la unidad médica de 16.0% (IC95%: 14.9-17.1). El riesgo relativo fue de 0.40 (IC95%: 0.34-0.47) para trabajadores que permanecieron laborando en la unidad de salud. Conclusión: la incidencia de COVID-19 fue superior en trabajadores de la salud con resguardo domiciliario que en aquellos que continuaron con actividades normales en la unidad médica.

Family with systemic arterial hypertension: epidemiological profile. / Familia con hipertensión arterial sistémica: perfil epidemiológico.

The aim of this study was to determine the epidemiological profile of the family with systemic arterial hypertension. A descriptive cross-sectional study was carried out in 268 families with this disease, the epidemiological profile included seven dimensions, sociodemographic, economic, family functionality, life cycle, family roles, health and use of services. The mean age of the families was 49.09 (SD: 15.57) years; 47.0% of the families had paid economic activity, 65.0% were functional, 52.4% were in the retirement and death stages, 43.1% presented obesity, in 50.0% the predominant role of the hypertensive patient was assumed by the mother, and the average annual number of family medicine consultations was 10.37 (SD: 4.31). The family with arterial hypertension is functional, although most of them are in the stage of retirement and death.

El objetivo fue determinar el perfil epidemiológico de grupos familiares con hipertensión arterial sistémica. Se realizó un estudio transversal descriptivo en 268 familias con esta enfermedad, el perfil epidemiológico incluyó siete dimensiones: sociodemográfico, económico, funcionalidad familiar, ciclo de vida, roles familiares, salud y uso de servicios. La edad promedio de las familias fue de 49,09 (DE: 15,57) años. El 47,0% de las familias tuvieron actividad económica remunerada; el 65,0% son funcionales; en el 52,4% predominó la etapa de jubilación y muerte; en el 50,0% la madre asumió el rol predominante del paciente con hipertensión; el 43,1% de las familias presentaron obesidad y el promedio anual de consultas de medicina familiar fue de 10,37 (DE: 4,31). La familia con hipertensión arterial es funcional, no obstante la mayoría se encuentra etapa de jubilación y muerte.

[Risk factors and the probability of developing dental decay in four-year-old children]. / Factores de riesgo y probabilidad de caries en niños de 4 años de edad.

OBJECTIVE: To identify the risk factors and to estimate the probability to develop dental decay. METHODS: A study of cases and controls in 4-year-old children, with a sample of 102 patients selected by quota was done. The oral hygiene habit, consumption of cariogenic food, annual oral evaluation and topical application of fluorine were studied as risk factors. The statically analysis included bivariated and multiple regression logistic, and estimation of the probability to develop decay. RESULTS: The oral hygiene habit was identified like the main risk factor with the greatest influence (OR=15.27) in the multiple model integrated with the variable mentioned, consumption of cariogenic food and oral annually evaluation. It turned out to be significant (p=0.00). The highest probability to present decay was of 76% and the lowest of 5%. CONCLUSIONS: Hygienic habit was the most important risk factor to develop dental decay.

[Opportunity cost for men who visit family medicine units in the city of Querétaro, Mexico]. / Costo de oportunidad en hombres que acuden a las unidades de medicina familiar en la ciudad de Querétaro, México.

OBJECTIVE: To determine the opportunity cost for men who seek care in the family medicine units (FMU) of the Mexican Social Security Institute (IMSS, Instituto Mexicano del Seguro Social) in the city of Querétaro. METHODS: A sample was selected of 807 men, ages 20 to 59 years, who sought care through the family medicine, laboratory, and pharmacy services provided by the FMU at the IMSS in Querétaro. Patients referred for emergency services and those who left the facilities without receiving care were excluded. The sample (n = 807) was calculated using the averages for an infinite population formula, with a confidence interval of 95% (CI95%) and an average opportunity cost of US$5.5 for family medicine, US$3.1 for laboratory services, and US$2.3 for pharmacy services. Estimates included the amount of time spent on travel, waiting, and receiving care; the number of people accompanying the patient, and the cost per minute of paid and unpaid job activities. The opportunity cost was calculated using the estimated cost per minute for travel, waiting, and receiving care for patients and their companions. RESULTS: The opportunity cost for the patient travel was estimated at US$0.97 (CI95%: 0.81-1.15), while wait time was US$5.03 (CI95%: 4.08-6.09) for family medicine, US$0.06 (CI95%: 0.05-0.08) for pharmacy services, and US$1.89 (CI95%: 1.56-2.25) for laboratory services. The average opportunity cost for an unaccompanied patient visit varied between US$1.10 for pharmacy services alone and US$8.64 for family medicine, pharmacy, and laboratory services. The weighted opportunity cost for family medicine was US$6.24. CONCLUSIONS: Given that the opportunity cost for men who seek services in FMU corresponds to more than half of a minimum salary, it should be examined from an institutional perspective whether this is the best alternative for care.

[Cost-effectiveness analysis in type 2 diabetes patients without hypertension]. / Costo-efectividad de SOHDi en pacientes con diabetes tipo 2 sin hipertensión.

OBJECTIVE: To determine SOHDi program cost-effectiveness (S = overweight, O = obesity, H = hypertension, Di = diabetes) in type 2 diabetes patients (DM2) without hypertension. METHODS: Sample included 32 patients. The effectiveness was measured by the blood glucose values. The SOHDi intervention cost included physician medical attention cost (PMAC), laboratory cost (LC), education group cost and individual evaluation cost. The cost of the traditional alternative medical attention (TAMA) contemplated PMAC and LC. The analysis cost-effectiveness included different intervals measurements, equal or smaller than 140 mg/dL blood glucose levels. RESULTS: The percentage of population with equal or smaller than 140 mg/dL blood glucose (effectiveness) in SOHDi was 23.3%, in TAMA was 44.8%. The average cost in SOHDi was $2202.22; in TAMA $1930.79. In the cases with blood glucose equal or smaller to 140 mg/dL the cost of effectiveness of 50% was $4726 in SOHDi and $2155 in TAMA. In this same situation the effectiveness by $1000 was 10.58% in SOHDi and 23.20% in TAMA. CONCLUSIONS: The SOHDi group is not the best alternative, at least not in the present operational conditions.

[To face up the disease strategy as a risk factor for the life style in type 2 diabetics]. / Estrategia de afrontamiento de la diabetes como factor de riesgo para el estilo de vida.

OBJECTIVE: To identify to the life style as a risk factor after the strategy of facing the disease in type 2 diabetic patients. METHODS: A study of cases and controls was made in patients with type 2 diabetes of five primary care units in the metropolitan area of Queretaro city. The sample size was of 48 patients by group. They were chosen by quota in the waiting room. Sociodemographic variables and health aspects were included in the questionnaire. The life style was investigated by the Instrument to Measure the Style of Life in Diabetics (IMEVID). For the evaluation of type of facing the scale of Strategy of Facing was used as opposed to extreme risks. Measures of central tendency, χ² and odds ratio were included. RESULTS: The type of active facing was a risk factor for the style of life with a p = 0.0001. CONCLUSIONS: The strategy of active facing disease is a risk factor for the style of life in the type 2 diabetic patient.

Institutional cost of the patient with chronic kidney disease managed with hemodialysis. / Costo institucional del paciente con enfermedad renal crónica manejada con hemodiálisis.

BACKGROUND: Chronic kidney disease cost is considered high for health systems due to the amount of supplies required for treatment and increasing prevalence. OBJECTIVE: Determine institutional cost of hemodialysis in chronic kidney disease. METHOD: Cost design from the institutional perspective, in patients with chronic kidney disease managed with hemodialysis. The sample size was 269 and the sample technique for consecutive cases. Annual fixed average cost (times and movements technique) and annual variable average cost (microcosting technique) adjusted by use of services, helped to identify annual average cost by function of production and service, the sum of these resulted in annual cost of care. Statistical analysis included averages and projections. RESULTS: The average annual cost of the patient with chronic kidney disease on hemodialysis varies between $223,183 and $257,000; the cost in life is $1,198,968. The institutional total cost it corresponds to between 1.47% and 1.73% of the budget. CONCLUSIONS: Hemodialysis cost in chronic kidney disease is high for the institution, however, hemodialysis allows the survival of the patient.

INTRODUCCIÓN: El costo de la enfermedad renal crónica es alto para los sistemas de salud debido a los insumos y la prevalencia. OBJETIVO: Determinar el costo institucional del tratamiento del paciente con enfermedad renal crónica en manejo con hemodiálisis. MÉTODO: Estudio de costos desde la perspectiva institucional, realizado en pacientes con enfermedad renal crónica manejada con hemodiálisis. El tamaño de muestra fue de 269 y la técnica muestral fue por casos consecutivos. El costo promedio fijo anual (técnica de tiempos y movimientos) y el costo promedio variable anual (técnica de microcosteo) ajustado por el perfil de uso de servicios identificaron el costo promedio anual por función de producción y servicio, y la suma de estos, el costo anual de la atención. El análisis estadístico incluyó promedios y proyecciones. RESULTADOS: El costo promedio anual del paciente con enfermedad renal crónica manejado con hemodiálisis varía entre $223,183 y $257,000; el costo en la vida es de $1,198,968. El costo total para la institución supone entre el 1.47% y el 1.73% del presupuesto. CONCLUSIONES: El costo de la hemodiálisis en la enfermedad renal crónica es alto para la institución; sin embargo, la hemodiálisis permite la supervivencia de los pacientes.

[Relationship between functional social support and vital satisfaction in the elderly]. / Relación entre apoyo social funcional y satisfacción vital del adulto mayor jubilado.

BACKGROUND: To determine the relationship between functional social support and vital satisfaction of the elder retirement adult. METHODS: Comparative cross-sectional study in retired adults aged 60 years and more. Two groups were integrated (high and low satisfaction) evaluated with Moral Scale of Satisfaction of the Geriatric Center of Philadelphia modified and validated by Montorio. The sample size was calculated with comparative cross-sectional studies formula, presence of the social support of 80 % in the group of high satisfaction and 50 % in the one of low satisfaction (n = 29). The selection was made at random using the payroll listing of retirees. Social demographic variables were studied. Relationship between the retirement and functional social support was evaluated with the scale of Functional Social Support of Duker-UNC-11. RESULTS: Sociodemographic characteristics and those related to the retirement did not present significant statistical differences (p > 0.05) in the groups of high and low satisfaction. There was an association between the functional social support and the vital satisfaction with odds ratio of 3.00 (95%CI = 1.08-8.32). CONCLUSIONS: Functional social support and vital satisfaction in the elderly were associated.

Risk factors for developing acute kidney injury in elderly patients / Factores de riesgo para desarrollar lesión renal aguda en pacientes ancianos

Background: The incidence of acute kidney injury in hospitalized elderly is a frequent event that makes them prone to complications and can even lead to death. Therefore, identifying risk factors for developing acute kidney injury becomes a priority in the process of care of the elderly. Objective: To identify the main risk factors for acute kidney injury in hospitalized elderly and, on the basis of those risk factors, calculate the probability of presentation. Methods: Case-control study nested in a cohort, which included patients of 60 years or older, admitted to the Internal Medicine service at an institution of social security in Querétaro, Mexico. Patients with acute kidney injury were identified as cases and patients without acute kidney injury were included in the control group. Acute kidney injury was diagnosed when there was an increased creatinine level ≥ 0.3 mg/dL (≥ 26.4 mmol/L) in a period < 48 hours. Results: Hypovolemia and infection were identified as risk factors for acute kidney injury and they were included into the model of multiple logistic regression (y = 1,111 + 1,063 [infection] + 1.422 [hypovolemia]), (p = 0.002). The highest probability of having acute kidney injury was 80%. Conclusions: Two factors for acute kidney injury and a prediction model were identified.

Introducción: la lesión renal aguda en pacientes ancianos hospitalizados es un evento frecuente que los predispone a complicaciones e incluso a la muerte. Es así que al atender a un anciano es prioritario identificar los factores de riesgo para presentar tal evento. Objetivo: identificar los principales factores de riesgo para lesión renal aguda en el anciano hospitalizado y a partir de ellos, calcular la probabilidad de presentación. Métodos: estudio de casos y controles anidado en una cohorte que incluyó pacientes de 60 años o más, ingresados en el servicio de medicina interna de una institución de seguridad social en Querétaro, México. Se identificó como caso al paciente con lesión renal aguda y como control al paciente sin lesión renal aguda. La lesión renal aguda se diagnosticó cuando existió un incremento de la creatinina ≥ 0.3 mg/dL (≥ 26.4 mmol/L) en un tiempo < 48 horas. Resultados: se identificaron como factores de riesgo para lesión renal aguda la hipovolemia y la infección, se integraron al modelo de regresión logística múltiple (y = −1.111 + 1.063 [infección] + 1.422 [hipovolemia]) p = 0.002. La probabilidad más alta de presentar lesión renal aguda fue de 80%. Conclusiones: se identificaron dos factores para lesión renal aguda y un modelo de predicción.

Direct cost of medical care in patients with gonarthrosis. / Costo directo de la atención médica en pacientes con gonartrosis.

OBJECTIVE: To determine the cost of medical care in patients with gonarthrosis. MATERIAL AND METHODS: Cost study in patients over 40 years of age with gonarthrosis, diagnosed according to the radiological classification of Kellgren and Lawrence. The average annual cost (euros) was estimated taking the unit cost plus average use of services such as family medicine, imaging, laboratory, electrodiagnosis, orthopedics, hospitalization, physical therapy, surgery, nutrition, preoperative assessment and medication. Projections based on assumptions were made for three scenarios. RESULTS: Grade 2 gonarthrosis predominated at 39.7% (95% confidence interval, 33.8 - 45.6). The annual cost of care for a patient with gonarthrosis was €108.87 in the intermediate scenario, €86.73 in the lower cost scenario and €132.60 in the higher cost scenario. For a population of 119,530,753 inhabitants, with 10,937,064 gonarthrosis patients, the annual cost in the intermediate scenario was €1,190,685,273 and represented 4.48% of the health expenditure. CONCLUSION: The average annual cost of gonarthrosis is relatively low, but when related to prevalence and prevalence trends, it can become a serious problem for health services.

Cost of medical attention in patients with Chronic Obstructive Pulmonary Disease / Costo de la atención médica en pacientes con enfermedad pulmonar obstructiva crónica

Background: The chronic obstructive pulmonary disease is a preventable entity, when it develops the patient suffers severe complications, with a high economic impact for the patient and for health services. Objetive: To determine the cost of medical care in patients with chronic obstructive pulmonary disease (COPD). Methods: Using a cost design, the files of patients with COPD who attended the pulmonology clinic were analyzed. The size of the sample (n = 265) was calculated with the formula of averages of a finite population. The sample units were captured with the simple random technique. The study variables were: sociodemographic characteristics, characteristics of COPD, annual use profile, unit cost per service, total cost per service and total cost of medical care. The analysis plan included averages, percentages, confidence intervals and health expenditure projections. Results: The average annual cost of patient care with COPD was $ 89 479.08, of which $ 61 267.63 corresponded to medications. With a COPD prevalence of 25% in a population of 46 million, the calculated cost of care was $ 347 805 183 960. Conclusion: The cost of medical care in patients with COPD was high, at the expense of medications.

Introducción: la enfermedad pulmonar obstructiva crónica es una entidad prevenible, cuando se desarrolla, el enfermo sufre complicaciones severas, con un alto impacto económico para el paciente y para los servicios de salud. Objetivo: determinar el costo de la atención médica en pacientes con enfermedad pulmonar obstructiva crónica (EPOC). Métodos: con un diseño de costos se analizaron los expedientes de pacientes con EPOC que acudieron a consulta de neumología. El tamaño de la muestra (n = 265) se calculó con la fórmula de promedios de una población finita. Las unidades muestrales se capturaron con la técnica aleatoria simple. Las variables de estudio fueron: características sociodemográficas, características de la EPOC, perfil de uso anual, costo unitario por servicio, costo total por servicio y costo total de la atención médica. El plan de análisis incluyó promedios, porcentajes, intervalos de confianza y proyecciones del gasto en salud. Resultados: el costo promedio anual de la atención del paciente con EPOC fue $89 479.08, de los cuales $61 267.63 correspondieron a medicamentos. Con una prevalencia de EPOC de 25% en una población de 46 millones, el costo calculado de la atención fue $347 805 183 960. Conclusión: el costo de la atención médica en pacientes con EPOC fue alto en buena medida a expensas de los medicamentos.

Efectividad de la vacuna para SARS-CoV-2 sobre hospitalizaciones por COVID-19 durante la cuarta ola epidémica en Querétaro, México Vacunación y hospitalización en COVID-19

Objetivo: Evaluar el efecto protector de la vacuna para SARS-CoV-2 para hospitalizaciones por COVID-19 durante la cuarta ola epidémica en Querétaro, México. Métodos: Diseño de cohorte retrospectiva en pacientes con COVID-19 durante la cuarta ola (19 de diciembre de 2021 al 9 de enero de 2022). Grupos expuestos, antecedente de vacuna anti COVID-19 (vacuna de adenovirus modificado genéticamente y vacuna de ácido ribonucleico mensajero), grupo no expuesto, no vacuna. El diagnóstico de COVID-19 se realizó con la prueba antigénica rápida en exudado orofaringeo, prueba practicada entre el primero y quinto día del inicio de sintomatología. Se incluyeron todos los pacientes que acudieron al servicio de salud por sintomatología, con prueba positiva y dos dosis de la vacuna. El análisis estadístico incluyó chi cuadrada, riesgo relativo e intervalo de confianza para riesgo relativo. Resultados: Se estudiaron 52 pacientes con vacuna de adenovirus modificado genéticamente, 119 con vacuna de ácido ribonucleico mensajero y 336 pacientes no vacunados. En pacientes no vacunados la incidencia de hospitalización fue 62,2%, en pacientes con vacuna adenovirus modificado genéticamente la hospitalización fue 23,1% (p<0.001), riesgo relativo de 0,37 (IC 95%; 0,22-0,61); y en pacientes con vacuna de ácido ribonucleico mensajero la incidencia de hospitalización fue 1,7% (p<0.001), riesgo relativo de 0,03 (IC 95%; 0,006-0,10). Conclusiones: La vacuna anti COVID-19 en el ámbito poblacional es efectiva para evitar hospitalización en pacientes que presentan cuadro agudo de COVID-19 en la cuarta ola.

Objective: To assess the protective effect of the vaccine against SARS-CoV-2 upon hospitalizations due to COVID-19 during the fourth epidemic wave in Queretaro, Mexico. Methods: This investigation was designed as a retrospective cohort study in patients with COVID-19 during the fourth wave of the epidemic (December 19th, 2021, to January 9th, 2022). The exposed group consisted in those subjects who had received a vaccine against COVID-19 (genetically modified adenovirus vaccine and messenger ribonucleic acid vaccine); and the non-exposed group consisted in those people who were not vaccinated. Diagnosis of COVID-19 was made with a rapid antigenic test in oropharyngeal exudate, and the test was performed between the first and fifth day after the onset of symptoms. All patients who came to healthcare facilities because of symptoms, with a positive test and having received two doses of the vaccine. Statistical analysis included chi-square, relative risk, and confidence intervals (CI) for the relative risk. Results: Fifty-two patients who received a genetically modified vaccine, 119 who received a messenger ribonucleic acid vaccine, and 336 non vaccinated subjects were included in the study. The frequency of hospitalization was 62,2% in non-vaccinated persons, this rate was 23,1% (p<0.001), and relative risk was 0,37 (95% CI; 0,22-0,61) in those who received a genetically modified adenovirus vaccine, and it was 1.7% (p<0.001), and relative risk was 0,03 (95% CI; 0,006-0,10) in those who received the messenger ribonucleic acid vaccine. Conclusions: From a population point of view, the vaccine against COVID-19 was effective for preventing hospitalization in patients with acute COVID-19 disease during the fourth epidemic wave.

Familia con hipertensión arterial sistémica: perfil epidemiológico / Family with systemic arterial hypertension: epidemiological profile

RESUMEN El objetivo fue determinar el perfil epidemiológico de grupos familiares con hipertensión arterial sistémica. Se realizó un estudio transversal descriptivo en 268 familias con esta enfermedad, el perfil epidemiológico incluyó siete dimensiones: sociodemográfico, económico, funcionalidad familiar, ciclo de vida, roles familiares, salud y uso de servicios. La edad promedio de las familias fue de 49,09 (DE: 15,57) años. El 47,0% de las familias tuvieron actividad económica remunerada; el 65,0% son funcionales; en el 52,4% predominó la etapa de jubilación y muerte; en el 50,0% la madre asumió el rol predominante del paciente con hipertensión; el 43,1% de las familias presentaron obesidad y el promedio anual de consultas de medicina familiar fue de 10,37 (DE: 4,31). La familia con hipertensión arterial es funcional, no obstante la mayoría se encuentra etapa de jubilación y muerte.

ABSTRACT The aim of this study was to determine the epidemiological profile of the family with systemic arterial hypertension. A descriptive cross-sectional study was carried out in 268 families with this disease, the epidemiological profile included seven dimensions, sociodemographic, economic, family functionality, life cycle, family roles, health and use of services. The mean age of the families was 49.09 (SD: 15.57) years; 47.0% of the families had paid economic activity, 65.0% were functional, 52.4% were in the retirement and death stages, 43.1% presented obesity, in 50.0% the predominant role of the hypertensive patient was assumed by the mother, and the average annual number of family medicine consultations was 10.37 (SD: 4.31). The family with arterial hypertension is functional, although most of them are in the stage of retirement and death.

Enfermedades crónicas degenerativas como factor de riesgo de letalidad por COVID-19 en México / Chronic degenerative conditions as risk factors for lethal COVID-19 / Doenças crônicas degenerativas como fator de risco para letalidade por COVID-19

RESUMEN Objetivo. Determinar el riesgo de letalidad de las enfermedades crónicas degenerativas en pacientes con COVID-19. Métodos. Se realizo un estudio de cohorte, en expedientes clínicos electrónicos de pacientes con RT-PCR positiva para COVID-19 en atención ambulatoria o intrahospitalaria en una Institución de Seguridad Social de marzo 2020 a marzo 2021. Se integraron 2 grupos de estudio, el grupo expuesto se dividió en cuatro subgrupos, cada uno con diagnóstico único y exclusivo de una patología crónica (diabetes, hipertensión, obesidad o enfermedad renal crónica); el grupo no expuesto lo integraron expedientes de pacientes sin comorbilidades. Se revisaron 1 114 expedientes en total utilizando técnica muestral aleatoria simple, una vez obtenido el tamaño mínimo de muestra se calculó el riesgo relativo para cada enfermedad crónica, se realizaron combinaciones de 2, 3 y 4, con cada uno de ellos se realizó el análisis. Resultados. En ausencia de enfermedad crónica degenerativa la prevalencia de letalidad en COVID-19 es 3,8%; en presencia de diabetes mellitus tipo 2 la letalidad es 15,8; en hipertensión arterial de 15,6%; y en obesidad 15,0%. Cuando se combinan diabetes e hipertensión la letalidad es 54,1%; en diabetes y obesidad 36,8%; y en obesidad e hipertensión 28,1%. Conclusiones. En pacientes con COVID-19 el riesgo relativo para letalidad de letalidad en diabetes es 4,17; en hipertensión 4,13; y en obesidad 3,96. Cuando se combinan dos enfermedades crónicas el riesgo relativo se duplica o triplica, para diabetes e hipertensión el riesgo relativo para letalidad es 14,2; para diabetes y obesidad 9,73; y para obesidad e hipertensión 7,43. Es verdad que las enfermedades crónicas no se presentan solas, generalmente se encuentra asociadas, y desde esa perspectiva los riesgos relativos para letalidad ofrecidos en este artículo adquieren relevancia.

ABSTRACT Objective. To determine the relative risk of a lethal outcome associated with chronic degenerative conditions in patients with COVID-19. Methods. A cohort study was conducted using electronic medical records belonging to patients who tested positive for COVID-19 on RT-PCR while receiving care as outpatients or inpatients in a social security system facility between March 2020 and March 2021. Two study groups were formed. The exposed group was divided into four subgroups, each of which was diagnosed with one and only one chronic condition (diabetes, hypertension, obesity, or chronic kidney disease); the unexposed group was obtained from the medical records of patients without comorbidities. A total of 1 114 medical records were examined using simple random sampling. Once the minimum sample size was reached, the relative risk was calculated for each chronic condition. Combinations of two, three, and four conditions were created, and each of them was included in the analysis. Results. In the absence of a chronic degenerative condition, the prevalence of a lethal outcome from COVID-19 is 3.8%; in the presence of type 2 diabetes mellitus, 15.8%; in the presence of arterial hypertension, 15.6%; and in the presence of obesity, 15.0%. For diabetes and hypertension combined, the prevalence of a lethal outcome is 54.1%; for diabetes and obesity combined, 36.8%, and for obesity and hypertension combined, 28.1%. Conclusion. In patients with COVID-19, the relative risk of a lethal outcome is 4.17 for those with diabetes, 4.13 for those with hypertension, and 3.96 for those with obesity. For two chronic conditions combined, the relative risk doubles or triples. The relative risk of a lethal outcome is 14.27 for diabetes plus hypertension; 9.73 for diabetes plus obesity, and 7.43 for obesity plus hypertension. Chronic conditions do not present alone; they generally occur together, hence the significance of the relative risks for lethal outcomes presented in this paper.

RESUMO Objetivo. Determinar o risco de letalidade conferido por doenças crônicas degenerativas em pacientes com COVID-19. Métodos. Foi realizado um estudo de coorte em prontuários eletrônicos de pacientes com RT-PCR positivo para COVID-19 em atendimento ambulatorial ou hospitalar em uma instituição de previdência social, no período de março de 2020 a março de 2021. Foram constituídos dois grupos de estudo. O grupo exposto foi dividido em quatro subgrupos, cada um com diagnóstico único e exclusivo de uma doença crônica (diabetes, hipertensão, obesidade ou doença renal crônica). O grupo não exposto foi constituído por prontuários de pacientes sem comorbidades. Foram revisados 1.114 prontuários no total, utilizando técnica de amostragem aleatória simples. Uma vez obtido o tamanho mínimo da amostra, foi calculado o risco relativo para cada doença crônica. Foram realizadas combinações de 2, 3 e 4, tendo sido feita a análise com cada uma delas. Resultados. Na ausência de doença crônica degenerativa, a prevalência de letalidade na COVID-19 é de 3,8%; na presença de diabetes mellitus tipo 2, a letalidade é de 15,8%; na presença de hipertensão arterial, 15,6%; e na presença de obesidade, 15%. Quando tanto diabetes como hipertensão estão presentes, a letalidade é de 54,1%; com diabetes e obesidade, 36,8%; e obesidade com hipertensão, 28,1%. Conclusões. Em pacientes com COVID-19, o risco relativo de letalidade é de 4,17 naqueles com diabetes; 4,13 naqueles com hipertensão; e 3,96 naqueles com obesidade. Quando duas doenças crônicas são combinadas, o risco relativo dobra ou triplica. Para diabetes e hipertensão, o risco relativo de letalidade é 14,27; para diabetes e obesidade, 9,73; e para obesidade e hipertensão, 7,43. As doenças crônicas não ocorrem sozinhas (geralmente estão associadas), e nessa perspectiva os riscos relativos de letalidade apresentados neste artigo tornam-se relevantes.

Prevalencia del uso de medicina tradicional herbolaria y el perfil de uso en pacientes con diabetes tipo 2 de una zona urbana

RESUMEN En México la interculturalidad en salud se plantea como una integración de dos sistemas de conocimiento, el conocimiento ancestral carente de bases científicas y que se transmite a través de las generaciones, y el modelo médico convencional. En múltiples estudios se describe que existe un gran porcentaje de médicos que han recibido pacientes que hacen uso de esta terapéutica. El objetivo fue identificar la prevalencia del uso de medicina tradicional herbolaria y el perfil de uso en pacientes con diabetes tipo 2 en una zona urbana. Se realizó un estudio observacional, transversal descriptivo en pacientes con diagnóstico de diabetes mellitus tipo 2, pertenecientes a un sistema de seguridad social de la ciudad de Querétaro, en un periodo mayor a 6 meses. El plan de análisis estadístico incluyó promedios, porcentajes, intervalos de confianza para promedios e intervalos de confianza para porcentajes. Se identificó que la prevalencia de uso de la medicina tradicional herbolaria era de 22.2%, con una edad promedio de 60.98 años, con predominio en el sexo femenino y una escolaridad secundaria o menos, la planta más utilizada fue moringa en un 45%, el uso más frecuente para el control glucémico en un 97% y su consumo era como agua de tiempo en la mayoría de las plantas. En este estudio se pudo describir la prevalencia de uso en una zona urbana, así como el perfil de las personas que hacen uso de esta terapéutica, con la finalidad de generar nuevas informaciones y promover el estudio de estas prácticas.

ABSTRACT In Mexico the interculturality in health is posed as an integration of the two systems of knowledge, the ancient knowledge lacking scientific bases which is transmitted through generations, and the conventional medical model. In multiple studies, the existence of a great percentage of medical doctors that have received patients using this therapy is described. The objective was to identify the prevalence of the use of herbal traditional medicine and the profile of use in patients with diabetes type 2 in an urban zone. This was an observational, transversal descriptive study performed in patients with diagnostic of diabetes mellitus type 2, belonging to a system of social security in Queretaro city, in a period greater than 6 months. The plan of statistical analysis included averages, percentages, confidence intervals for averages and percentages. The prevalence of use of the herbal traditional medicine was 22.2% with and average age of 60.98 years old, with predominance of the female sex and a scholarship of middle school or less, the plant mostly used was moringa in a 45%, the most frequent use was the glycemic control in 97% and the consumption was as natural water in most plants. In this study, it was described the prevalence of the use in an urban zone, as well as the profile of the people that use this therapy, with the purpose of generate new information and promote the study of these practices.

Prevalencia de lesiones intraepiteliales de alto grado en mujeres de 15-25 años con el reporte de citología de infección por el virus del papiloma humano / Prevalence of high-grade intraepithelial lesions in women aged 15-25 years with cytology report of human papillomavirus infection

Resumen OBJETIVO: Determinar la prevalencia de lesiones intraepiteliales de alto grado en mujeres de 15 a 25 años, con un reporte de citología de cambios en el epitelio atribuibles a la infección por el virus del papiloma humano. MATERIALES Y MÉTODOS: Estudio retrospectivo, transversal y descriptivo efectuado con base en la información de los expedientes de mujeres de 15 a 25 años atendidas entre los meses de enero del 2015 a diciembre del 2020 en la Clínica de Displasias del Hospital General Regional 1 de Querétaro, México, con reporte de citología con cambios en el epitelio atribuibles a la infección por el virus de papiloma humano.Criterios de inclusión: Expedientes de mujeres de 15 a 25 años con reporte de cambios en el epitelio atribuibles a la infección por el VPH reportados en la citología. Criterio de exclusión: Expediente incompleto. El plan de análisis estadístico incluyó: promedios, intervalos de confianza para promedios, porcentajes e intervalo de confianza para porcentajes. RESULTADOS: Se revisaron 823 expedientes con reporte de citología con cambios en el epitelio atribuibles a la infección por VPH. La edad promedio de las mujeres fue de 23.28 años (IC95%: 23.24-23.52), la edad media al inicio de la vida sexual fue de 16.01 años (IC95%: 15.92-16.10). El 7.0% (IC95%: 5.3-8.7) tuvieron lesiones intraepiteliales de alto grado en la citología y en la colposcopia. CONCLUSIÓN: La prevalencia de lesiones intraepiteliales de alto grado en mujeres de 15 a 25 años con reporte de cambios en el epitelio atribuibles a la infección por el VPH es del 7.0% tanto para la citología como para la colposcopia.

Abstract OBJECTIVE: To know the prevalence of high-grade intraepithelial lesions in women aged 15 to 25 years, with a cytology report of changes in the epithelium attributable to human papillomavirus infection. MATERIALS AND METHODS: Retrospective, tranversal and descriptive study performed at the Dysplasia Clinic of the Regional General Hospital 1 of Querétaro, Mexico, from January 2015 to December 2020. Inclusion criteria: files of women aged 15 to 25 years with report of changes in the epithelium attributable to HPV infection reported on cytology. Exclusion criteria: incomplete records. The statistical analysis plan included: averages, confidence intervals for averages, percentages, and confidence interval for percentages. RESULTS: We reviewed 823 files with cytology reports of epithelial changes attributable to HPV infection. The mean age of the women was 23.28 years (95%CI: 23.24-23.52), the mean age at sexual debut was 16.01 years (95%CI: 15.92-16.10). 7.0% (95%CI: 5.3-8.7) had high-grade intraepithelial lesions on cytology and colposcopy. CONCLUSION: The prevalence of high-grade intraepithelial lesions in women aged 15-25 years with reported epithelial changes attributable to HPV infection is 7.0% for cytology and for colposcopy.