Detalhe da pesquisa
1.
Evaluation of a Janus kinase 1 inhibitor, PF-04965842, in healthy subjects: A phase 1, randomized, placebo-controlled, dose-escalation study.
Br J Clin Pharmacol
; 84(8): 1776-1788, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29672897
2.
Renal effects induced by prolonged mPGES1 inhibition.
Am J Physiol Renal Physiol
; 306(1): F68-74, 2014 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24197070
3.
Novel benzoxazole inhibitors of mPGES-1.
Bioorg Med Chem Lett
; 23(3): 907-11, 2013 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23266122
4.
Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation.
Bioorg Med Chem Lett
; 23(4): 1114-9, 2013 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23260349
5.
Synthesis and biological evaluation of substituted benzoxazoles as inhibitors of mPGES-1: use of a conformation-based hypothesis to facilitate compound design.
Bioorg Med Chem Lett
; 23(4): 1120-6, 2013 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23298810
6.
Macrocyclic Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonists.
ACS Med Chem Lett
; 14(2): 191-198, 2023 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36793423
7.
Homo-timeric structural model of human microsomal prostaglandin E synthase-1 and characterization of its substrate/inhibitor binding interactions.
J Comput Aided Mol Des
; 23(1): 13-24, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18777160
8.
Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases.
J Med Chem
; 61(3): 1130-1152, 2018 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29298069
9.
Synthesis, crystal structure, and activity of pyrazole-based inhibitors of p38 kinase.
J Med Chem
; 50(23): 5712-9, 2007 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17948975
10.
Development of a high-throughput crystal structure-determination platform for JAK1 using a novel metal-chelator soaking system.
Acta Crystallogr F Struct Biol Commun
; 72(Pt 11): 840-845, 2016 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27827355
11.
Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor.
Biochem Pharmacol
; 79(10): 1445-54, 2010 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20067770
12.
Benzodipyrazoles: a new class of potent CDK2 inhibitors.
Bioorg Med Chem Lett
; 15(5): 1315-9, 2005 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15713378