Detalhe da pesquisa
1.
Pharmacology of a Potent and Novel Inhibitor of the NOD-Like Receptor Pyrin Domain-Containing Protein 3 (NLRP3) Inflammasome that Attenuates Development of Nonalcoholic Steatohepatitis and Liver Fibrosis.
J Pharmacol Exp Ther
; 386(2): 242-258, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37308266
2.
Structure-based design and discovery of potent and selective lysine-specific demethylase 1 (LSD1) inhibitors.
Bioorg Med Chem Lett
; 29(1): 103-106, 2019 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30409536
3.
Structure-based design and discovery of potent and selective KDM5 inhibitors.
Bioorg Med Chem Lett
; 28(9): 1490-1494, 2018 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29627262
4.
Design, synthesis and biological evaluation of novel 4-phenylisoquinolinone BET bromodomain inhibitors.
Bioorg Med Chem Lett
; 28(10): 1811-1816, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29657099
5.
JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders.
Sci Rep
; 13(1): 13524, 2023 08 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37598239
6.
Discovery of novel aminoquinazolin-7-yl 6,7-dihydro-indol-4-ones as potent, selective inhibitors of heat shock protein 90.
Bioorg Med Chem Lett
; 22(7): 2550-4, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22386527
7.
Brain-permeable small-molecule inhibitors of Hsp90 prevent alpha-synuclein oligomer formation and rescue alpha-synuclein-induced toxicity.
J Pharmacol Exp Ther
; 332(3): 849-57, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19934398
8.
Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1).
J Med Chem
; 63(23): 14522-14529, 2020 12 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33034194
9.
Targeting of multiple signaling pathways by the Hsp90 inhibitor SNX-2112 in EGFR resistance models as a single agent or in combination with erlotinib.
Oncol Res
; 18(5-6): 229-42, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-20225761
10.
Discovery of benzamide tetrahydro-4H-carbazol-4-ones as novel small molecule inhibitors of Hsp90.
Bioorg Med Chem Lett
; 18(12): 3517-21, 2008 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18511277
11.
Synthesis and evaluation of pyrazolo[1,5-b]pyridazines as selective cyclin dependent kinase inhibitors.
Bioorg Med Chem Lett
; 18(21): 5758-62, 2008 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18835709
12.
Author Correction: JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders.
Sci Rep
; 13(1): 20081, 2023 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-37973811
13.
Discovery of novel benzimidazoles as potent inhibitors of TIE-2 and VEGFR-2 tyrosine kinase receptors.
J Med Chem
; 50(18): 4453-70, 2007 Sep 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-17676829
14.
Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models.
ACS Med Chem Lett
; 8(8): 869-874, 2017 Aug 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28835804
15.
Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors.
J Med Chem
; 48(5): 1610-9, 2005 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-15743202
16.
Fluorescence linked enzyme chemoproteomic strategy for discovery of a potent and selective DAPK1 and ZIPK inhibitor.
ACS Chem Biol
; 8(12): 2715-23, 2013 Dec 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-24070067
17.
Application of chemoproteomics to drug discovery: identification of a clinical candidate targeting hsp90.
Chem Biol
; 17(7): 686-94, 2010 Jul 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-20659681
18.
Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents.
J Med Chem
; 52(14): 4288-305, 2009 Jul 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-19552433
19.
Small molecule inhibitors of Hsp90 potently affect inflammatory disease pathways and exhibit activity in models of rheumatoid arthritis.
Arthritis Rheum
; 58(12): 3765-75, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19035474
20.
Discovery of 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor.
J Med Chem
; 51(15): 4632-40, 2008 Aug 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-18620382