Detalhe da pesquisa
1.
Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening.
J Am Chem Soc
; 141(22): 8951-8968, 2019 06 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31060360
2.
Design, Synthesis and Characterization of Covalent KDM5 Inhibitors.
Angew Chem Int Ed Engl
; 58(2): 515-519, 2019 01 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30431220
3.
Structural analysis of human KDM5B guides histone demethylase inhibitor development.
Nat Chem Biol
; 12(7): 539-45, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27214403
4.
Phosphorylation of synaptic vesicle protein 2A at Thr84 by casein kinase 1 family kinases controls the specific retrieval of synaptotagmin-1.
J Neurosci
; 35(6): 2492-507, 2015 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25673844
5.
Deliberately Losing Control of C-H Activation Processes in the Design of Small-Molecule-Fragment Arrays Targeting Peroxisomal Metabolism.
ChemMedChem
; 15(24): 2513-2520, 2020 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32812371
6.
A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function.
J Med Chem
; 62(20): 9008-9025, 2019 10 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31550156
7.
C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays.
Eur J Med Chem
; 177: 316-337, 2019 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31158747
8.
Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells.
Cell Chem Biol
; 24(3): 371-380, 2017 Mar 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-28262558
9.
Docking and Linking of Fragments To Discover Jumonji Histone Demethylase Inhibitors.
J Med Chem
; 59(4): 1580-98, 2016 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-26699912
10.
8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors.
J Med Chem
; 59(4): 1388-409, 2016 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-26741168