Detalhe da pesquisa
1.
Population pharmacokinetics and humanized dosage regimens matching the peak, area, trough, and range of amikacin plasma concentrations in immune-competent murine bloodstream and lung infection models.
Antimicrob Agents Chemother
; 68(3): e0139423, 2024 Mar 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38289076
2.
Individual Components of Polymyxin B Modeled via Population Pharmacokinetics to Design Humanized Dosage Regimens for a Bloodstream and Lung Infection Model in Immune-Competent Mice.
Antimicrob Agents Chemother
; 67(5): e0019723, 2023 05 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37022153
3.
Polymyxin B Pharmacodynamics in the Hollow-Fiber Infection Model: What You See May Not Be What You Get.
Antimicrob Agents Chemother
; 65(8): e0185320, 2021 07 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34097487
4.
Emergence of Resistance to Ceftazidime-Avibactam in a Pseudomonas aeruginosa Isolate Producing Derepressed blaPDC in a Hollow-Fiber Infection Model.
Antimicrob Agents Chemother
; 65(6)2021 05 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33782013
5.
Developing New Drugs for Mycobacterium tuberculosis Therapy: What Information Do We Get from Preclinical Animal Models?
Antimicrob Agents Chemother
; 64(12)2020 11 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32958720
6.
Determination of the Dynamically Linked Indices of Fosfomycin for Pseudomonas aeruginosa in the Hollow Fiber Infection Model.
Antimicrob Agents Chemother
; 62(6)2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29581114
7.
Clinical Regimens of Favipiravir Inhibit Zika Virus Replication in the Hollow-Fiber Infection Model.
Antimicrob Agents Chemother
; 62(9)2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29967017
8.
The Combination of Fosfomycin plus Meropenem Is Synergistic for Pseudomonas aeruginosa PAO1 in a Hollow-Fiber Infection Model.
Antimicrob Agents Chemother
; 62(12)2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30249700
9.
Dilution Factor of Quantitative Bacterial Cultures Obtained by Bronchoalveolar Lavage in Patients with Ventilator-Associated Bacterial Pneumonia.
Antimicrob Agents Chemother
; 62(1)2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29038277
10.
Imidazole-derived agonists for the neurotensin 1 receptor.
Bioorg Med Chem Lett
; 24(1): 262-7, 2014 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24332089
11.
Erratum for Drusano et al., "Dilution Factor of Quantitative Bacterial Cultures Obtained by Bronchoalveolar Lavage in Patients with Ventilator-Associated Bacterial Pneumonia".
Antimicrob Agents Chemother
; 62(4)2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29588353
12.
Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor.
Bioorg Med Chem Lett
; 22(21): 6656-60, 2012 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23010269
13.
Utility of a Novel Three-Dimensional and Dynamic (3DD) Cell Culture System for PK/PD Studies: Evaluation of a Triple Combination Therapy at Overcoming Anti-HER2 Treatment Resistance in Breast Cancer.
Front Pharmacol
; 9: 403, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29765318
14.
Discovery of ML314, a Brain Penetrant Non-Peptidic ß-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor.
ACS Med Chem Lett
; 4(9): 846-851, 2013 Jul 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-24611085
15.
In Vivo Rapid Assessment of Compound Exposure (RACE) for Profiling the Pharmacokinetics of Novel Chemical Probes.
Curr Protoc Chem Biol
; 4(4): 299-309, 2012 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23788556
16.
Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy.
ACS Chem Neurosci
; 3(3): 221-236, 2012 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22737280
17.
Discovery of a Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase inhibitor (R,Z)-N-((1-ethylpyrrolidin-2-yl)methyl)-2-(2-fluorobenzylidene)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide (ML276) that reduces parasite growth in vitro.
J Med Chem
; 55(16): 7262-72, 2012 Aug 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-22813531
18.
Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation.
ACS Med Chem Lett
; 2(10): 780-785, 2011 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-22003428
19.
Potent, selective, and orally available benzoisothiazolone phosphomannose isomerase inhibitors as probes for congenital disorder of glycosylation Ia.
J Med Chem
; 54(10): 3661-8, 2011 May 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-21539312
20.
Inhibition of protein kinase C-driven nuclear factor-kappaB activation: synthesis, structure-activity relationship, and pharmacological profiling of pathway specific benzimidazole probe molecules.
J Med Chem
; 53(12): 4793-7, 2010 Jun 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-20481485