1.
Nat Cell Biol
; 9(12): 1337-8; author reply 1339, 2007 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18059353
Assuntos
Encéfalo/fisiologia , alfa Carioferinas/metabolismo , Animais , Encéfalo/crescimento & desenvolvimento , Diferenciação Celular , Feminino , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Knockout , Isoformas de Proteínas/genética , Isoformas de Proteínas/metabolismo , Células de Purkinje/citologia , Células de Purkinje/metabolismo , Células Piramidais/citologia , Células Piramidais/metabolismo , Medula Espinal/crescimento & desenvolvimento , Medula Espinal/fisiologia , alfa Carioferinas/genética
2.
PLoS One
; 6(3): e18310, 2011 Mar 29.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21479251
RESUMO
Importin α is involved in the nuclear import of proteins. It also contributes to spindle assembly and nuclear membrane formation, however, the underlying mechanisms are poorly understood. Here, we studied the function of importin α7 by gene targeting in mice and show that it is essential for early embryonic development. Embryos lacking importin α7 display a reduced ability for the first cleavage and arrest completely at the two-cell stage. We show that the zygotic genome activation is severely disturbed in these embryos. Our findings indicate that importin α7 is a new member of the small group of maternal effect genes.