Detalhe da pesquisa
1.
A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk.
Cell
; 133(7): 1149-61, 2008 Jun 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-18585350
2.
New piperazine multi-effect drugs prevent neurofibrillary degeneration and amyloid deposition, and preserve memory in animal models of Alzheimer's disease.
Neurobiol Dis
; 129: 217-233, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30928644
3.
The neuroprotective activity of heat-treated human platelet lysate biomaterials manufactured from outdated pathogen-reduced (amotosalen/UVA) platelet concentrates.
J Biomed Sci
; 26(1): 89, 2019 Oct 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-31666073
4.
CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes.
Nature
; 495(7440): 223-6, 2013 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-23467090
5.
AMP-activated Protein Kinase Controls Immediate Early Genes Expression Following Synaptic Activation Through the PKA/CREB Pathway.
Int J Mol Sci
; 19(12)2018 Nov 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-30467274
6.
A modification-specific peptide-based immunization approach using CRM197 carrier protein: Development of a selective vaccine against pyroglutamate Aß peptides.
Mol Med
; 22: 841-849, 2017 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-27900387
7.
CALHM1 ion channel elicits amyloid-ß clearance by insulin-degrading enzyme in cell lines and in vivo in the mouse brain.
J Cell Sci
; 128(13): 2330-8, 2015 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25999473
8.
Inhibition of AMP-activated protein kinase signaling alleviates impairments in hippocampal synaptic plasticity induced by amyloid ß.
J Neurosci
; 34(36): 12230-8, 2014 Sep 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-25186765
9.
CALHM1 controls the Ca²âº-dependent MEK, ERK, RSK and MSK signaling cascade in neurons.
J Cell Sci
; 126(Pt 5): 1199-206, 2013 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23345406
10.
Calcium homeostasis modulator 1 (CALHM1) is the pore-forming subunit of an ion channel that mediates extracellular Ca2+ regulation of neuronal excitability.
Proc Natl Acad Sci U S A
; 109(28): E1963-71, 2012 Jul 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-22711817
11.
CB2 receptor deficiency increases amyloid pathology and alters tau processing in a transgenic mouse model of Alzheimer's disease.
Mol Med
; 20: 29-36, 2014 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24722782
12.
Recovery of brain biomarkers following peroxisome proliferator-activated receptor agonist neuroprotective treatment before ischemic stroke.
Proteome Sci
; 12: 24, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24944524
13.
Growth arrest-specific 1 binds to and controls the maturation and processing of the amyloid-beta precursor protein.
Hum Mol Genet
; 20(10): 2026-36, 2011 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21357679
14.
CB2 receptor deficiency increases amyloid pathology and alters tau processing in a transgenic mouse model of Alzheimer's disease.
Mol Med
; 19: 357-64, 2013 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24408112
15.
Identification and biology of α-secretase.
J Neurochem
; 120 Suppl 1: 34-45, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22121879
16.
Resveratrol mitigates lipopolysaccharide- and Aß-mediated microglial inflammation by inhibiting the TLR4/NF-κB/STAT signaling cascade.
J Neurochem
; 120(3): 461-72, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22118570
17.
Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-ß peptide degradation.
FASEB J
; 25(1): 219-31, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-20852062
18.
AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism.
J Biol Chem
; 285(12): 9100-13, 2010 Mar 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-20080969
19.
Small-molecule activators of AMP-activated protein kinase (AMPK), RSVA314 and RSVA405, inhibit adipogenesis.
Mol Med
; 17(9-10): 1022-30, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21647536
20.
CALHM1 P86L polymorphism modulates CSF Aß levels in cognitively healthy individuals at risk for Alzheimer's disease.
Mol Med
; 17(9-10): 974-9, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21629967