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1.
J Clin Periodontol ; 51(1): 97-107, 2024 01.
Artigo em Inglês | MEDLINE | ID: mdl-37850252

RESUMO

AIM: To investigate the association between periodontal diseases, airflow limitation and incident chronic obstructive pulmonary disease (COPD) in a large-scale prospective UK Biobank cohort. MATERIALS AND METHODS: Our approach comprised a cross-sectional study and a prospective cohort. Periodontal diseases were determined based on the participants' self-reported dental symptoms, including painful gums, bleeding gums and loose teeth. Logistic regression and Cox proportional hazards models were used to evaluate the association of periodontal diseases with airflow limitation and incident COPD in the cross-sectional study and the prospective cohort, respectively. RESULTS: The cross-sectional study involved 495,610 participants. Multivariable analysis found that periodontal diseases were significantly associated with airflow limitation (odds ratio = 1.036, 95% confidence interval [CI]: 1.015-1.059). The cohort study included 379,266 participants with a median follow-up period of 12.68 years. An elevated risk of incident COPD was associated with the presence of periodontal diseases (hazard ratio: 1.248, 95% CI: 1.174-1.326). The effect was consistent among subgroups, including baseline age (≤65 or >65 years), sex, smoking status and diabetes mellitus. CONCLUSIONS: Periodontal diseases are associated with airflow limitation and elevated COPD incidence. Maintaining good periodontal health in patients with chronic bronchitis and emphysema may help prevent the onset of COPD.


Assuntos
Doenças Periodontais , Doença Pulmonar Obstrutiva Crônica , Humanos , Idoso , Estudos Transversais , Estudos Prospectivos , Biobanco do Reino Unido , Estudos de Coortes , Bancos de Espécimes Biológicos , Fatores de Risco , Doença Pulmonar Obstrutiva Crônica/complicações , Doença Pulmonar Obstrutiva Crônica/epidemiologia , Doença Pulmonar Obstrutiva Crônica/diagnóstico , Doenças Periodontais/complicações , Doenças Periodontais/epidemiologia
2.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi ; 41(2): 335-341, 2024 Apr 25.
Artigo em Zh | MEDLINE | ID: mdl-38686415

RESUMO

Place cell with location tuning characteristics play an important role in brain spatial cognition and navigation, but there is relatively little research on place cell screening and its influencing factors. Taking pigeons as model animals, the screening process of pigeon place cell was given by using the spike signal in pigeon hippocampus under free activity. The effects of grid number and filter kernel size on the place field of place cells during the screening process were analyzed. The results from the real and simulation data showed that the proposed place cell screening method presented in this study could effectively screen out place cell, and the research found that the size of place field was basically inversely proportional to the number of grids divided, and was basically proportional to the size of Gaussian filter kernel in the overall trend. This result will not only help to determine the appropriate parameters in the place cell screening process, but also promote the research on the neural mechanism of spatial cognition and navigation of birds such as pigeons.


Assuntos
Columbidae , Hipocampo , Columbidae/fisiologia , Animais , Hipocampo/citologia , Hipocampo/fisiologia , Células de Lugar/fisiologia , Navegação Espacial/fisiologia , Cognição , Potenciais de Ação
3.
J Environ Manage ; 326(Pt A): 116850, 2023 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-36436437

RESUMO

The effects of coagulation on the removal efficiency of different fractions of effluent organic matter (EfOM) from wastewater treatment plants were investigated to identify changes in their structural characteristics and the influences on trihalomethane formation potential (THMFP) and haloacetic acid formation potential (HAAFP). The results indicated that coagulation performed better for the removal of hydrophobic base (HOB) and hydrophobic neutral (HON) fractions than hydrophilic (HI) and hydrophobic acid (HOA) fractions. The removal efficiency was higher under neutral than under acidic conditions for all fractions. As a result, lower levels of THMFP and HAAFP were detected at pH7. The excitation-emission matrix spectra indicated that the HI fraction contained humic acid-like substances that reacted with chlorine to form THMs. The HON fraction contained soluble microbial byproduct-like substances with a higher potential to create HAAs. The results of Fourier transform infrared (FT-IR) spectroscopy, X-ray photoelectron spectroscopy (XPS), and high-pressure size exclusion chromatography (HP-SEC) of the raw and coagulated water indicated that a higher molecular weight, α-carbon, COOH, aromatic structures, and polysaccharides were associated with a higher production of disinfection byproducts (DBP). These results elucidate the coagulation efficiencies of EfOM fractions associated with different mechanisms and facilitate the prediction of DBP formation by each fraction based on specific structural characteristics.


Assuntos
Cloro , Desinfecção , Cloreto de Alumínio , Espectroscopia de Infravermelho com Transformada de Fourier , Trialometanos
4.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi ; 40(2): 327-334, 2023 Apr 25.
Artigo em Zh | MEDLINE | ID: mdl-37139765

RESUMO

The neural stimulator is a core component of animal robots. While the control effect of animal robots is influenced by various factors, the performance of the neural stimulator plays a decisive role in regulating animal robots. In order to optimize animal robots, embedded neural stimulators had been developed using flexible printed circuit board technology. This innovation not only enabled the stimulator to generate parameter-adjustable biphasic current pulses through control signals, but also optimized its carrying mode, material, and size, overcoming the disadvantages of traditional backpack or head-inserted stimulators, which have poor concealment and are prone to infection. Static, in vitro, and in vivo performance tests of the stimulator demonstrated that it not only had precise pulse waveform output capability, but also was lightweight and small in size. It had excellent in vivo performance in both laboratory and outdoor environments. Our study has high practical significance for the application of animal robots.


Assuntos
Robótica , Animais
5.
Cell Tissue Res ; 390(1): 93-112, 2022 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-35821438

RESUMO

Glomerular mesangial cell proliferation and extracellular matrix accumulation contribute to the progression of diabetic nephropathy (DN). As a conserved stress-inducible protein, sestrin2 (Sesn2) plays critical role in the regulation of oxidative stress, inflammation, autophagy, metabolism, and endoplasmic reticulum stress. In this study, we investigated the role of Sesn2 on renal damage in diabetic kidney using transgenic mice overexpressing Sesn2 and the effect of Sesn2 on mesangial cell proliferation and extracellular matrix accumulation in diabetic conditions and the possible molecular mechanisms involved. Sesn2 overexpression improved renal function and decreased glomerular hypertrophy, albuminuria, mesangial expansion, extracellular matrix accumulation, and TGF-ß1 expression, as well as oxidative stress in diabetic mice. In vitro experiments, using human mesangial cells (HMCs), revealed that Sesn2 overexpression inhibited high glucose (HG)-induced proliferation, fibronectin and collagen IV production, and ROS generation. Meanwhile, Sesn2 overexpression restored phosphorylation levels of Lats1 and YAP and inhibited TEAD1 expression. Inhibition of Lats1 accelerated HG-induced proliferation and expression of fibronectin and collagen IV. Verteporfin, an inhibitor of YAP, suppressed HG-induced proliferation and expression of fibronectin and collagen IV. However, Sesn2 overexpression reversed Lats1 deficiency-induced Lats1 and YAP phosphorylation, nuclear expression levels of YAP and TEAD1, and proliferation and fibronectin and collagen IV expressions in HMCs exposed to HG. In addition, antioxidant NAC or tempol treatment promoted phosphorylation of Lats1 and YAP and inhibited TEAD1 expression, proliferation, and fibronectin and collagen IV accumulation in HG-treated HMCs. Taken together, Sesn2 overexpression inhibited mesangial cell proliferation and fibrosis via regulating Hippo pathway in diabetic nephropathy. Induction of Sesn2 may be a potential therapeutic target in diabetic nephropathy.


Assuntos
Diabetes Mellitus Experimental , Nefropatias Diabéticas , Animais , Antioxidantes/farmacologia , Colágeno Tipo IV/metabolismo , Diabetes Mellitus Experimental/complicações , Diabetes Mellitus Experimental/metabolismo , Nefropatias Diabéticas/metabolismo , Matriz Extracelular/metabolismo , Fibronectinas/metabolismo , Glucose/metabolismo , Via de Sinalização Hippo , Humanos , Rim/metabolismo , Camundongos , Proteínas Nucleares , Proteínas Serina-Treonina Quinases , Espécies Reativas de Oxigênio/metabolismo , Sestrinas , Fator de Crescimento Transformador beta1/metabolismo , Verteporfina/metabolismo , Verteporfina/farmacologia , Verteporfina/uso terapêutico
6.
J Sci Food Agric ; 102(15): 7221-7230, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-35730767

RESUMO

BACKGROUND: The soy isoflavone microbial metabolites dihydrodaidzein (DHD), dihydrogenistein (DHG), equol and 5-hydroxy-equol are generally more biologically active than their precursors daidzein and genistein. Bacteria responsible for isoflavone metabolism have been isolated and identified. Fermented soymilk is a potential functional food; however, there are few lactic acid bacteria capable of metabolizing soy isoflavones. RESULTS: A newly isolated Gram-positive facultative anaerobic bacterium, which was named Lactobacillus acidipiscis HAU-FR7, was isolated from the traditional Chinese fermented soy product 'stinky tofu'. Bacterium strain HAU-FR7 can grow under aerobic conditions and can also convert most of the daidzin and genistin in soymilk into DHD and DHG, respectively. The concentrations of DHD and DHG produced were 183 and 134 µmol L-1 , respectively, after fermentation for 24 h. Strain HAU-FR7 does not produce the biogenic amines cadaverine, putrescine, histamine or tyramine, and an antibiotic susceptibility test showed that HAU-FR7 is sensitive to nine of the ten tested antibiotics, except for vancomycin. Moreover, the 1,1-diphenyl-2- picrylhydrazyl free radical scavenging capacity of soymilk fermented with HAU-FR7 was significantly higher than that of unfermented soymilk. CONCLUSION: A facultative anaerobic lactic acid bacterium, designated Lactobacillus acidipiscis HAU-FR7, is capable of reducing the soy isoflavone glucosides daidzin and genistin in soymilk to DHD and DHG efficiently, even in the presence of atmospheric oxygen. The biotransformation activity of HAU-FR7 grown in soymilk is higher than that in de Man-Rogosa-Sharpe liquid culture medium. © 2022 Society of Chemical Industry.


Assuntos
Isoflavonas , Alimentos de Soja , Leite de Soja , Humanos , Fermentação , Glucosídeos/metabolismo , Composição de Bases , Filogenia , RNA Ribossômico 16S , Análise de Sequência de DNA , Leite de Soja/metabolismo , Isoflavonas/metabolismo , Bactérias/metabolismo , China
7.
J Cell Mol Med ; 25(24): 11278-11289, 2021 12.
Artigo em Inglês | MEDLINE | ID: mdl-34786818

RESUMO

Oxidative stress (OS)-induced mitochondrial damage and the subsequent osteoblast dysfunction contributes to the initiation and progression of osteoporosis. Notoginsenoside R1 (NGR1), isolated from Panax notoginseng, has potent antioxidant effects and has been widely used in traditional Chinese medicine. This study aimed to investigate the protective property and mechanism of NGR1 on oxidative-damaged osteoblast. Osteoblastic MC3T3-E1 cells were pretreated with NGR1 24 h before hydrogen peroxide administration simulating OS attack. Cell viability, apoptosis rate, osteogenic activity and markers of mitochondrial function were examined. The role of C-Jun N-terminal kinase (JNK) signalling pathway on oxidative injured osteoblast and mitochondrial function was also detected. Our data indicate that NGR1 (25 µM) could reduce apoptosis as well as restore osteoblast viability and osteogenic differentiation. NGR1 also reduced OS-induced mitochondrial ROS and restored mitochondrial membrane potential, adenosine triphosphate production and mitochondrial DNA copy number. NGR1 could block JNK pathway and antagonize the destructive effects of OS. JNK inhibitor (SP600125) mimicked the protective effects of NGR1while JNK agonist (Anisomycin) abolished it. These data indicated that NGR1 could significantly attenuate OS-induced mitochondrial damage and restore osteogenic differentiation of osteoblast via suppressing JNK signalling pathway activation, thus becoming a promising agent in treating osteoporosis.


Assuntos
Ginsenosídeos/farmacologia , Sistema de Sinalização das MAP Quinases/efeitos dos fármacos , Osteoblastos/efeitos dos fármacos , Osteoblastos/metabolismo , Estresse Oxidativo/efeitos dos fármacos , Trifosfato de Adenosina/metabolismo , Animais , Apoptose/efeitos dos fármacos , Biomarcadores , Linhagem Celular , Sobrevivência Celular/efeitos dos fármacos , Camundongos , Mitocôndrias/efeitos dos fármacos , Mitocôndrias/metabolismo , Superóxidos/metabolismo
8.
J Integr Neurosci ; 20(4): 945-954, 2021 Dec 30.
Artigo em Inglês | MEDLINE | ID: mdl-34997717

RESUMO

Previous work demonstrates that nidopallium caudolaterale, which is considered to be an analog of the mammalian prefrontal cortex, participates in goal-directed navigation in pigeons. However, its role remains unclear. To clarify its role, two goal-directed navigation tasks in plus-maze were designed, in which the goal location of one is random, and the other is fixed, i.e., the random-goal task and the fixed-goal task. The animals were trained to run from the starting location to the goal location in accordance with the cue in the plus-maze. The goal location is variable for the random-goal task but unchanged for the fixed-goal task. The results have demonstrated that the time point of nidopallium caudolaterale neuron response is consistent with decision-making. During the decision-making, the firing rates significantly increased in two tasks, which can also decode the direction of upcoming movement in the random-goal task. However, the location of decision-making is different between the tasks mentioned above. The decision-making window is at the intersection in the random-goal task, which is a departure in the fixed-goal task. In addition, these results also provide evidence that the neural activities obtained from the nidopallium caudolaterale may contain the decision-making information during goal-directed navigation. These results suggest that the avian nidopallium caudolaterale and the mammalian prefrontal cortex may play a similar role in goal-directed spatial decision-making. Additionally, these also may provide some support to understand the neural mechanism of decision-making for different species.


Assuntos
Comportamento Animal/fisiologia , Tomada de Decisões/fisiologia , Córtex Pré-Frontal/fisiologia , Navegação Espacial/fisiologia , Animais , Columbidae , Eletrocorticografia , Objetivos
9.
Genomics ; 112(6): 3846-3855, 2020 11.
Artigo em Inglês | MEDLINE | ID: mdl-32619572

RESUMO

Insects employ a sensitive chemosensory system to accurately recognize external odorants, which help them to make a behavioral response quickly. Semiothisa cinerearia has caused serious damages to Sophora japonica L. in recent years, and there is still a lack of effective strategy to control the pest. Although the two type-II sex pheromones of S. cinerearia, 6Z,9Z-cis-3,4-epoxy-17:H and 3Z,6Z,9Z-17:H, have been identified for 30 years, the molecular mechanisms underlying the chemosensation of the two sex pheromones are still unknown. Here, we found that there are differences in the types of antennae sensilla between sexes, and revealed 146 putative chemosensory genes in the antennal transcriptome. Among these genes, 11 and 40 of them displayed male-biased and female-biased expression, respectively. Our findings greatly improve the chemosensory gene resources for S. cinerearia and provide a foundation for functional studies of these sex-biased genes on the chemosensation of sex pheromones and on other sex-related behaviors.


Assuntos
Mariposas/genética , Receptores Odorantes/genética , Atrativos Sexuais/fisiologia , Animais , Feminino , Perfilação da Expressão Gênica , Masculino , Mariposas/fisiologia , Filogenia , Transcriptoma
10.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi ; 37(2): 317-323, 2020 Apr 25.
Artigo em Zh | MEDLINE | ID: mdl-32329285

RESUMO

As an interface between external electronic devices and internal neural nuclei, microelectrodes play an important role in many fields, such as animal robots, deep brain stimulation and neural prostheses. Aiming at the problem of high price and complicated fabrication process of microelectrode, a microelectrode twisting machine based on open source electronic prototyping platform (Arduino) and three-dimensional printing technology was proposed, and its microelectrode fabrication performance and neural stimulation performance were verified. The results show that during the fabrication of microelectrodes, the number of positive twisting turns of the electrode wire should generally be set to about 1.8 times of its length, and the number of reverse twisting rings is independent of the length, generally about 5. Moreover, compared with the traditional instrument, the device is not only inexpensive and simple to manufacture, but also has good expandability. It has a positive significance for both the personalization and popularization of microelectrode fabrication and the reduction of experimental cost.


Assuntos
Desenho de Equipamento , Microeletrodos , Impressão Tridimensional
11.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi ; 35(5): 786-793, 2018 10 25.
Artigo em Zh | MEDLINE | ID: mdl-30370720

RESUMO

Both spike and local field potential (LFP) signals are two of the most important candidate signals for neural decoding. At present there are numerous studies on their decoding performance in mammals, but the decoding performance in birds is still not clear. We analyzed the decoding performance of both signals recorded from nidopallium caudolaterale area in six pigeons during the goal-directed decision-making task using the decoding algorithm combining leave-one-out and k-nearest neighbor (LOO- kNN). And the influence of the parameters, include the number of channels, the position and size of decoding window, and the nearest neighbor k value, on the decoding performance was also studied. The results in this study have shown that the two signals can effectively decode the movement intention of pigeons during the this task, but in contrast, the decoding performance of LFP signal is higher than that of spike signal and it is less affected by the number of channels. The best decoding window is in the second half of the goal-directed decision-making process, and the optimal decoding window size of LFP signal (0.3 s) is shorter than that of spike signal (1 s). For the LOO- kNN algorithm, the accuracy is inversely proportional to the k value. The smaller the k value is, the larger the accuracy of decoding is. The results in this study will help to parse the neural information processing mechanism of brain and also have reference value for brain-computer interface.

12.
Sensors (Basel) ; 16(5)2016 05 13.
Artigo em Inglês | MEDLINE | ID: mdl-27187404

RESUMO

A new way of measuring planar position for micrometric and sub-micrometric applications is presented with a mono sensing electrode and hybrid-frequency excitation. The sensing theory and operation principle are described and summarized, and a printed circuit board (PCB) sensor prototype is built and tested. It is shown by the experimental results that a very simple structure and geometric relationship are achieved. Meanwhile, displacement sensitivity on an order of 1.50 mV per micron and measurement repeatability better than 0.002 mm are easily fulfilled for a square zone of 256 mm², making it a valuable alternative measurement device candidate for flexible and low-cost planar position detection.

13.
Diabetes Metab Syndr Obes ; 17: 75-92, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38196512

RESUMO

Background: Diabetic kidney disease (DKD) is characterized by renal fibrosis, and the pathogenesis of renal fibrosis is still not definitely confirmed. MiR-204-5p plays an important role in the regulation of fibrosis, autophagy and oxidative stress. In this study, we aimed to investigate the role of miR-204-5p on renal damage in diabetic kidneys and the underlying mechanisms involved. Methods: In vivo, AAV-Ksp-miR-204-5p mimics were injected into mice via tail vein. In vitro, high glucose-induced HK-2 cells were treated with miR-204-5p inhibitor, miR-204-5p mimics, ATG5 siRNA, tertiary butyl hydroquinone (TBHQ), ML385, or 3-Methyladenine (3-MA). FISH and qRT-PCR were used to detect miR-204-5p expression. The expressions of protein and mRNA were detected by Western blotting, immunofluorescence, immunohistochemistry and qRT-PCR. The concentration of fibronectin in HK-2 cells culture medium was detected by ELISA. Results: The expression of miR-204-5p in diabetic kidneys was significantly inhibited than that in control group. Delivering miR-204-5p mimics increased miR-204-5p expression, improved renal function, inhibited renal fibrosis and oxidative stress, and restored autophagy in db/db mice. In vitro, the expression of miR-204-5p was inhibited by HG treatment in HK-2 cells. MiR-204-5p mimics effectively increased miR-204-5p expression and reduced fibronectin and collagen I expression, restored autophagy dysfunction, and increased Nrf2 expression, whereas these alterations were abrogated by Nrf2 inhibitor ML385, autophagy inhibitor 3-methyladenine (3-MA, 5 mM) treatment or ATG5 siRNA transfection in HG-induced HK-2 cells. In addition, miR-204-5p inhibitor significantly inhibited miR-204-5p expression and aggravated HG-induced fibronectin and collagen I expression, autophagy dysfunction, and decreased Nrf2 expression, while these alterations were abolished by Nrf2 activator TBHQ. Furthermore, the binding of miR-204-5p with Keap1 was confirmed by luciferase reporter assay and miR-204-5p negatively regulated Keap1 expression, resulting in the activation of Nrf2 pathway. Conclusion: MicroRNA-204-5p protects against the progression of diabetic renal fibrosis by restoring autophagy via regulating Keap1/Nrf2 pathway.

14.
Cell Death Discov ; 10(1): 314, 2024 Jul 07.
Artigo em Inglês | MEDLINE | ID: mdl-38972937

RESUMO

Kidney fibrosis is considered to be the ultimate aggregation pathway of chronic kidney disease (CKD), but its underlying mechanism remains elusive. Protein kinase C-delta (PKC-δ) plays critical roles in the control of growth, differentiation, and apoptosis. In this study, we found that PKC-δ was highly upregulated in human biopsy samples and mouse kidneys with fibrosis. Rottlerin, a PKC-δ inhibitor, alleviated unilateral ureteral ligation (UUO)-induced kidney fibrosis, inflammation, VDAC1 expression, and cGAS-STING signaling pathway activation. Adeno-associated virus 9 (AAV9)-mediated VDAC1 silencing or VBIT-12, a VDAC1 inhibitor, attenuated renal injury, inflammation, and activation of cGAS-STING signaling pathway in UUO mouse model. Genetic and pharmacologic inhibition of STING relieved renal fibrosis and inflammation in UUO mice. In vitro, hypoxia resulted in PKC-δ phosphorylation, VDAC1 oligomerization, and activation of cGAS-STING signaling pathway in HK-2 cells. Inhibition of PKC-δ, VDAC1 or STING alleviated hypoxia-induced fibrotic and inflammatory responses in HK-2 cells, respectively. Mechanistically, PKC-δ activation induced mitochondrial membrane VDAC1 oligomerization via direct binding VDAC1, followed by the mitochondrial DNA (mtDNA) release into the cytoplasm, and subsequent activated cGAS-STING signaling pathway, which contributed to the inflammation leading to fibrosis. In conclusion, this study has indicated for the first time that PKC-δ is an important regulator in kidney fibrosis by promoting cGAS-STING signaling pathway which mediated by VDAC1. PKC-δ may be useful for treating renal fibrosis and subsequent CKD.

15.
Clin Oral Investig ; 17(6): 1601-9, 2013 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-23064974

RESUMO

OBJECTIVES: The aim of this study was to evaluate the accuracy of measuring bone thickness surrounding dental implants and the reliability of assessing existence and completion of osseous integration of augmentation material using a cone beam computed tomography (CBCT) system. MATERIALS AND METHODS: In jaws of foxhounds, artificial defects were regenerated by guided bone regeneration and then dental implants were placed. After putting down the dogs, the jaws were separated from the bodies and exposed in a CBCT system. The bone thickness was measured on both buccal and oral sides of the implants at different levels. Every examiner evaluated existence and integration of bone augmentation materials (BAM) and the completeness of marginal implant covering. The same measurements and evaluations were performed at digital images of the corresponding histological sections. RESULTS: The mean and the standard deviation of the differences between radiological and histological measurements of peri-implant bone thickness were -0.22 mm and 0.77 mm, respectively. Sensitivity and specificity were 0.77 and 0.60 for existence of BAM, 0.59 and 0.74 for completed integration, and 0.39 and 0.71 for full covering of the implant surface. CONCLUSIONS: The present study indicates that the PaX Duo3D(®) CBCT system allows measurements of peri-implant bone thickness at an accuracy of half a millimeter, and--within limits--assessing the existence and integration of BAM. It is not possible to evaluate whether the implant is covered completely by hard tissue. CLINICAL RELEVANCE: Peri-implant bone thickness is a key factor for obtaining initial implant stability. The accuracy of its measurement has clinical impact. Radiological assessment of existence and integration of BAM would be of great benefit to the evaluation of augmentation procedures.


Assuntos
Perda do Osso Alveolar/cirurgia , Processo Alveolar/diagnóstico por imagem , Aumento do Rebordo Alveolar/métodos , Tomografia Computadorizada de Feixe Cônico/estatística & dados numéricos , Implantes Dentários , Perda do Osso Alveolar/diagnóstico por imagem , Processo Alveolar/patologia , Animais , Autoenxertos/transplante , Densidade Óssea/fisiologia , Substitutos Ósseos/uso terapêutico , Transplante Ósseo/métodos , Colágeno , Tomografia Computadorizada de Feixe Cônico/métodos , Implantação Dentária Endóssea/métodos , Cães , Regeneração Tecidual Guiada Periodontal/métodos , Processamento de Imagem Assistida por Computador/métodos , Processamento de Imagem Assistida por Computador/estatística & dados numéricos , Imageamento Tridimensional/métodos , Imageamento Tridimensional/estatística & dados numéricos , Membranas Artificiais , Osseointegração/fisiologia , Polietilenoglicóis , Distribuição Aleatória , Reprodutibilidade dos Testes , Sensibilidade e Especificidade
16.
ScientificWorldJournal ; 2013: 831564, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-23818832

RESUMO

Optimal control using particle swarm optimization (PSO) is put forward in a parallel hybrid hydraulic excavator (PHHE). A power-train mathematical model of PHHE is illustrated along with the analysis of components' parameters. Then, the optimal control problem is addressed, and PSO algorithm is introduced to deal with this nonlinear optimal problem which contains lots of inequality/equality constraints. Then, the comparisons between the optimal control and rule-based one are made, and the results show that hybrids with the optimal control would increase fuel economy. Although PSO algorithm is off-line optimization, still it would bring performance benchmark for PHHE and also help have a deep insight into hybrid excavators.


Assuntos
Algoritmos , Indústria da Construção/instrumentação , Retroalimentação , Modelos Teóricos , Veículos Automotores , Simulação por Computador , Desenho de Equipamento , Análise de Falha de Equipamento
17.
Tissue Eng Part B Rev ; 29(1): 62-77, 2023 02.
Artigo em Inglês | MEDLINE | ID: mdl-35994388

RESUMO

Temporomandibular joint osteoarthritis (TMJOA) is a gradual degenerative jaw joint condition. Until recent years, TMJOA is still relatively unrecognized and ineffective to be treated. Appropriate animal models with reliable detection methods can help researchers understand the pathophysiology of TMJOA and find therapeutic options. In this study, we summarized common animal models of TMJOA created by chemical, surgical, mechanical, and genetical approaches. The relevant pathological symptoms and induction mechanisms were outlined. In addition, different pathological indicators, furthermore, emerging therapeutic regimens, such as intra-articular drug delivery and tissue engineering-based approaches to treat TMJOA based on these animal models, were summarized and updated. Understanding the physiology and pathogenesis of the TMJOA, together using various ways to diagnose the TMJOA, were elaborated, including imaging techniques, molecular techniques for detecting inflammatory cytokines, histochemical staining, and histomorphometry measures. A more reliable diagnosis will enable the development of new prevention and more effective treatment strategies and thereby improve the quality of life of TMJOA patients. Impact statement Temporomandibular joint osteoarthritis (TMJOA) affects 8 to 16 percent of the population worldwide. However, TMJOA is still relatively unrecognized and ineffective to be treated in the clinic. Appropriate animal models with reliable diagnostic methods can help researchers understand the pathophysiology of TMJOA and find therapeutic options. We herein summarized common animal models of TMJOA and various ways to diagnose the TMJOA. More importantly, emerging therapeutic regimens to treat TMJOA based on these animal models were summarized. With the aid of strategies listed, more effective treatment strategies will be developed and thereby improve the life quality of TMJOA patients.


Assuntos
Osteoartrite , Transtornos da Articulação Temporomandibular , Animais , Transtornos da Articulação Temporomandibular/diagnóstico , Transtornos da Articulação Temporomandibular/terapia , Qualidade de Vida , Osteoartrite/diagnóstico , Osteoartrite/terapia , Articulação Temporomandibular/patologia , Modelos Animais
18.
R Soc Open Sci ; 10(3): 221116, 2023 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-36866076

RESUMO

An electrical stimulator transmitting information into selected neural circuits is a promising approach for neural prostheses or animal robots. However, traditional stimulators are based on rigid printed circuit board (PCB) technology; technological limitations hindered the development of stimulators, especially for experiments involving free-moving subjects. Here we described a small (1.6 × 1.8 × 1.6 cm), lightweight (4 g, including a 100 mA h lithium battery) and multi-channel (eight unipolar or four bipolar biphasic channels) cubic wireless electrical stimulator exploiting flexible PCB technology. In comparison with the traditional stimulator, an appliance of both flexible PCB and cube structure makes it smaller and lighter, and enhances its stability. Stimulation sequences can be constructed with 100 selectable current levels, 40 selectable frequency levels and 20 selectable pulse-width-ratio levels. Moreover, the distance of wireless communication can reach approximately 150 m. Both in vitro and in vivo results have demonstrated functionality of the stimulator. The feasibility of remote pigeon's navigation using the proposed stimulator was successfully verified.

19.
Chem Sci ; 14(29): 7956-7965, 2023 Jul 26.
Artigo em Inglês | MEDLINE | ID: mdl-37502332

RESUMO

Composite polymer electrolytes (CPEs) with high ionic conductivity and favorable electrolyte/electrode interfacial compatibility are promising alternatives to liquid electrolytes. However, severe parasitic reactions in the Li/electrolyte interface and the air-unstable inorganic fillers have hindered their industrial applications. Herein, surface-edge opposite charged Laponite (LAP) multilayer particles with high air stability were grafted with imidazole ionic liquid (IL-TFSI) to enhance the thermal, mechanical, and electrochemical performances of polyethylene oxide (PEO)-based CPEs. The electrostatic repulsion between multilayers of LAP-IL-TFSI enables them to be easily penetrated by PEO segments, resulting in a pronounced amorphous region in the PEO matrix. Therefore, the CPE-0.2LAP-IL-TFSI exhibits a high ionic conductivity of 1.5 × 10-3 S cm-1 and a high lithium-ion transference number of 0.53. Moreover, LAP-IL-TFSI ameliorates the chemistry of the solid electrolyte interphase, significantly suppressing the growth of lithium dendrites and extending the cycling life of symmetric Li cells to over 1000 h. As a result, the LiFePO4||CPE-0.2LAP-IL-TFSI||Li cell delivers an outstanding capacity retention of 80% after 500 cycles at 2C at 60 °C. CPE-LAP-IL-TFSI also shows good compatibility with high-voltage LiNi0.8Co0.1Mn0.1O2 cathodes.

20.
ACS Appl Mater Interfaces ; 15(27): 32385-32394, 2023 Jul 12.
Artigo em Inglês | MEDLINE | ID: mdl-37365916

RESUMO

Lithium metal batteries have emerged as a promising candidate for next-generation power systems. However, the high reactivity of lithium metal with liquid electrolytes has resulted in decreased battery safety and stability, which poses a significant challenge. Herein, we present a modified laponite-supported gel polymer electrolyte (LAP@PDOL GPE) that was fabricated using in situ polymerization initiated by a redox-initiating system at ambient temperature. The LAP@PDOL GPE effectively facilitates the dissociation of lithium salts via electrostatic interaction and simultaneously constructs multiple lithium-ion transport channels within the gel polymer network. This hierarchical GPE demonstrates a remarkable ionic conductivity of 5.16 × 10-4 S cm-1 at 30 °C. Furthermore, the robust laponite component of the LAP@PDOL GPE forms a barrier against Li dendrite growth while also participating in the establishment of a stable electrode/electrolyte interface with Si-rich components. The in situ polymerization process further improves the interfacial contact, enabling the LiFePO4/LAP@PDOL GPE/Li cell to exhibit an impressive capacity of 137 mAh g-1 at 1C, with a capacity retention of 98.5% even after 400 cycles. In summary, the developed LAP@PDOL GPE shows great potential in addressing the critical issues of safety and stability associated with lithium metal batteries while also delivering improved electrochemical performance.

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