Detalhe da pesquisa
1.
Rational design, synthesis and biological evaluation of novel HIV-1 protease inhibitors containing 2-phenylacetamide derivatives as P2 ligands with potent activity against DRV-Resistant HIV-1 variants.
Bioorg Med Chem Lett
; 101: 129651, 2024 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38342391
2.
Discovery and development of benzene sulfonamide derivatives as anti-hepatic fibrosis agents.
Bioorg Med Chem Lett
; 88: 129290, 2023 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37080476
3.
Subplenones A-J: Dimeric Xanthones with Antibacterial Activity from the Endophytic Fungus Subplenodomus sp. CPCC 401465.
J Nat Prod
; 86(11): 2474-2486, 2023 11 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-37862150
4.
Design, synthesis, and anti-influenza A virus activity evaluation of novel indole containing derivatives of triazole.
Bioorg Med Chem Lett
; 64: 128681, 2022 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35304224
5.
A kind of HIV-1 protease inhibitors containing phenols with antiviral activity against DRV-resistant variants.
Bioorg Med Chem
; 64: 116760, 2022 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35483138
6.
Design and Evaluation of Novel HIV-1 Protease Inhibitors Containing Phenols or Polyphenols as P2 Ligands with High Activity against DRV-Resistant HIV-1 Variants.
Int J Mol Sci
; 23(22)2022 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36430656
7.
Design, synthesis, and antibacterial evaluation of PFK-158 derivatives as potent agents against drug-resistant bacteria.
Bioorg Med Chem Lett
; 41: 127980, 2021 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33766773
8.
Discovery of 1,8-naphthalidine derivatives as potent anti-hepatic fibrosis agents via repressing PI3K/AKT/Smad and JAK2/STAT3 pathways.
Bioorg Med Chem
; 49: 116438, 2021 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34610571
9.
Design, synthesis and anti-influenza A virus activity of novel 2,4-disubstituted quinazoline derivatives.
Bioorg Med Chem Lett
; 30(11): 127143, 2020 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32273213
10.
Design, synthesis and biological evaluation of HIV-1 protease inhibitors with morpholine derivatives as P2 ligands in combination with cyclopropyl as P1' ligand.
Bioorg Med Chem Lett
; 30(7): 127019, 2020 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32057582
11.
Design, synthesis, and biological activity evaluation of a series of pleuromutilin derivatives with novel C14 side chains.
Bioorg Med Chem Lett
; 30(7): 126969, 2020 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32014384
12.
Design and biological evaluation of novel HIV-1 protease inhibitors with isopropanol as P1' ligand to enhance binding with S1' subsite.
Bioorg Med Chem
; 28(16): 115623, 2020 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32690263
13.
A novel biphenyl compound IMB-S7 ameliorates hepatic fibrosis in BDL rats by suppressing Sp1-mediated integrin αv expression.
Acta Pharmacol Sin
; 41(5): 661-669, 2020 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-31932644
14.
Synthesis and biological evaluation of new HIV-1 protease inhibitors with purine bases as P2-ligands.
Bioorg Med Chem Lett
; 29(12): 1541-1545, 2019 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31014912
15.
Design, synthesis, and bioevaluation of a novel class of (E)-4-oxo-crotonamide derivatives as potent antituberculosis agents.
Bioorg Med Chem Lett
; 29(4): 539-543, 2019 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30630715
16.
Design, synthesis and biological evaluation of novel HIV-1 protease inhibitors with pentacyclic triterpenoids as P2-ligands.
Bioorg Med Chem Lett
; 29(3): 357-361, 2019 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30580917
17.
A novel ASBT inhibitor, IMB17-15, repressed nonalcoholic fatty liver disease development in high-fat diet-fed Syrian golden hamsters.
Acta Pharmacol Sin
; 40(7): 895-907, 2019 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-30573812
18.
Design, Synthesis, and Cytotoxic Activity of 3-Aryl-N-hydroxy-2-(sulfonamido)propanamides in HepG2, HT-1080, KB, and MCF-7 Cells.
Chem Biodivers
; 16(4): e1800646, 2019 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-30706997
19.
Synthesis and Biological Evaluation of Substituted Indole and Its Analogs as Influenza A Virus Inhibitors.
Chem Biodivers
; 16(2): e1800577, 2019 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-30536577
20.
Antibacterial Activity and Structure-Activity Relationship of a Series of Newly Synthesized Pleuromutilin Derivatives.
Chem Biodivers
; 16(2): e1800560, 2019 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-30467968