Social Media Use and Happiness in Adults with Autism Spectrum Disorder.

Social media (SM) use by adults with autism spectrum disorder (ASD) is not well understood. Co-occurring mental health concerns, such as depression, are common for adults with ASD. The current investigation explored the relationship between SM use and happiness in a population of adults with self-disclosed ASD. Of the 84 percent of the sample who used SM, those who used Facebook, the most popular site, were happier than those who did not. The same relationship did not exist for the second most popular site, Twitter. Happiness and SM use showed a quadratic relationship: Happiness and SM use increased together until they reached a point where happiness fell off. SM use by adults with ASD, specifically Facebook use in moderation, may enhance well-being and may be a protective factor against secondary mental health concerns common in this population.

The effect of dosing interval on the efficacy of misoprostol in the prevention of aspirin-induced gastric injury.

The effect of twice-daily administration of misoprostol on aspirin-induced gastric injury was evaluated. Twenty-four random-source dogs were divided into groups that received aspirin and misoprostol as follows: group I, aspirin 25 mg/kg PO q8h and placebo PO q8h; group II, aspirin 25 mg/kg PO q8h and misoprostol 3 microg/kg PO q8h; group III, aspirin 25 mg/kg PO q8h, misoprostol 3 microg/kg PO q12h, and placebo PO q24h; and group IV, aspirin 25 mg/kg PO q8h, misoprostol 3 microg/kg PO q24h, and placebo PO q12h for 28 days. Gastroscopy was performed on days -9, 5, 14, and 28. Visible lesions were scored on a scale of 1 (mucosal hemorrhage) to 11 (perforating ulcer). No difference in total score was identified between groups I and IV on any day. Median total scores for groups II and III were significantly (P < or = .05) lower compared to groups I and IV on day 5. Group III had a significantly lower score (P < or = .05) than groups I, II, and IV on day 28. This study suggests that misoprostol 3 microg/kg PO q12h is as effective as misoprostol 3 microg/kg PO q8h in preventing aspirin-induced gastric injury in this model. However, misoprostol 3 microg/ kg PO q8h was less effective in preventing aspirin-induced gastric injury on days 14 and 28 than in previous studies. No difference among numbers of dog-days of vomiting, diarrhea, or anorexia was detected among groups.