Detalhe da pesquisa
1.
Characterisation of a wild-type influenza (A/H1N1) virus strain as an experimental challenge agent in humans.
Virol J
; 12: 13, 2015 Feb 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-25645025
2.
Distinct muscarinic acetylcholine receptor subtypes mediate pre- and postsynaptic effects in rat neocortex.
BMC Neurosci
; 13: 42, 2012 Apr 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-22540185
3.
Quantitative analysis reveals multiple mechanisms of allosteric modulation of the mGlu5 receptor in rat astroglia.
Mol Pharmacol
; 79(5): 874-85, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21321061
4.
Orthosteric and allosteric modes of interaction of novel selective agonists of the M1 muscarinic acetylcholine receptor.
Mol Pharmacol
; 78(1): 94-104, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20413650
5.
The discovery of a series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles as highly brain penetrant, selective muscarinic M1 agonists.
Bioorg Med Chem Lett
; 20(18): 5434-8, 2010 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20709550
6.
Effects of positive allosteric modulators on single-cell oscillatory Ca2+ signaling initiated by the type 5 metabotropic glutamate receptor.
Mol Pharmacol
; 76(6): 1302-13, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19737913
7.
8-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones: dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors--part II.
Bioorg Med Chem Lett
; 19(8): 2338-42, 2009 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19286377
8.
New quinoline NK3 receptor antagonists with CNS activity.
Bioorg Med Chem Lett
; 19(3): 837-40, 2009 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19117759
9.
In vitro and in vivo characterization of the non-peptide NK3 receptor antagonist SB-223412 (talnetant): potential therapeutic utility in the treatment of schizophrenia.
Neuropsychopharmacology
; 33(7): 1642-52, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-17728699
10.
Pharmacological assessment of m1 muscarinic acetylcholine receptor-gq/11 protein coupling in membranes prepared from postmortem human brain tissue.
J Pharmacol Exp Ther
; 325(3): 869-74, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18322150
11.
Discovery of potent, orally bioavailable, selective 5-HT1A/B/D receptor antagonists.
J Med Chem
; 51(10): 2887-90, 2008 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-18433113
12.
Novel 5-HT(1A/1B/1D) receptors antagonists with potent 5-HT reuptake inhibitory activity.
Bioorg Med Chem Lett
; 18(20): 5581-5, 2008 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18829312
13.
6-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones: dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors.
Bioorg Med Chem Lett
; 18(20): 5653-6, 2008 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18799312
14.
SB-649915-B, a novel 5-HT1A/B autoreceptor antagonist and serotonin reuptake inhibitor, is anxiolytic and displays fast onset activity in the rat high light social interaction test.
Neuropsychopharmacology
; 32(10): 2163-72, 2007 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17356576
15.
Simultaneous blockade of 5-HT1A/B receptors and 5-HT transporters results in acute increases in extracellular 5-HT in both rats and guinea pigs: in vivo characterization of the novel 5-HT1A/B receptor antagonist/5-HT transport inhibitor SB-649915-B.
Psychopharmacology (Berl)
; 192(1): 121-33, 2007 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-17265079
16.
Discovery of the first potent, selective 5-hydroxytryptamine1D receptor antagonist.
J Med Chem
; 48(10): 3478-80, 2005 May 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-15887956
17.
Serotonergic targets in depression.
Curr Opin Pharmacol
; 2(1): 18-22, 2002 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-11786304
18.
A novel peptide-based pan-influenza A vaccine: a double blind, randomised clinical trial of immunogenicity and safety.
Vaccine
; 33(2): 396-402, 2015 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-24928790
19.
Design and synthesis of trans-3-(2-(4-((3-(3-(5-methyl-1,2,4-oxadiazolyl))- phenyl)carboxamido)cyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine (SB-414796): a potent and selective dopamine D3 receptor antagonist.
J Med Chem
; 46(23): 4952-64, 2003 11 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-14584946
20.
Therapeutic potential of serotonin antagonists in depressive disorders.
Expert Opin Investig Drugs
; 11(4): 457-67, 2002 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-11922855