Detalhe da pesquisa
1.
Evaluation of darunavir-derived HIV-1 protease inhibitors incorporating P2' amide-derivatives: Synthesis, biological evaluation and structural studies.
Bioorg Med Chem Lett
; 83: 129168, 2023 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36738797
2.
Discovery of a new flavin N5-adduct in a tyrosine to phenylalanine variant of d-Arginine dehydrogenase.
Arch Biochem Biophys
; 715: 109100, 2022 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34864048
3.
[Dyspepsia: a more complex approach]. / Dyspepsie: une approche plus complexe.
Rev Med Suisse
; 18(797): 1784-1787, 2022 Sep 28.
Artigo
em Francês
| MEDLINE | ID: mdl-36170129
4.
A Single-Point Mutation in d-Arginine Dehydrogenase Unlocks a Transient Conformational State Resulting in Altered Cofactor Reactivity.
Biochemistry
; 60(9): 711-724, 2021 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33630571
5.
Novel HIV PR inhibitors with C4-substituted bis-THF and bis-fluoro-benzyl target the two active site mutations of highly drug resistant mutant PRS17.
Biochem Biophys Res Commun
; 566: 30-35, 2021 08 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34111669
6.
Evolution of drug resistance in HIV protease.
BMC Bioinformatics
; 21(Suppl 18): 497, 2020 Dec 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-33375936
7.
Machine learning methods accurately predict host specificity of coronaviruses based on spike sequences alone.
Biochem Biophys Res Commun
; 533(3): 553-558, 2020 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32981683
8.
Potent antiviral HIV-1 protease inhibitor combats highly drug resistant mutant PR20.
Biochem Biophys Res Commun
; 519(1): 61-66, 2019 10 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-31474336
9.
Structural studies of antiviral inhibitor with HIV-1 protease bearing drug resistant substitutions of V32I, I47V and V82I.
Biochem Biophys Res Commun
; 514(3): 974-978, 2019 06 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-31092330
10.
Analysis of drug resistance in HIV protease.
BMC Bioinformatics
; 19(Suppl 11): 362, 2018 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-30343664
11.
Crystal structure of yeast nitronate monooxygenase from Cyberlindnera saturnus.
Proteins
; 86(5): 599-605, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29383742
12.
Design, synthesis, X-ray studies, and biological evaluation of novel macrocyclic HIV-1 protease inhibitors involving the P1'-P2' ligands.
Bioorg Med Chem Lett
; 27(21): 4925-4931, 2017 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28958624
13.
Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex.
Bioorg Med Chem
; 25(19): 5114-5127, 2017 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28434781
14.
Automated prediction of HIV drug resistance from genotype data.
BMC Bioinformatics
; 17 Suppl 8: 278, 2016 Aug 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-27586700
15.
Binding of Clinical Inhibitors to a Model Precursor of a Rationally Selected Multidrug Resistant HIV-1 Protease Is Significantly Weaker Than That to the Released Mature Enzyme.
Biochemistry
; 55(16): 2390-400, 2016 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-27039930
16.
In vitro heme biotransformation by the HupZ enzyme from Group A streptococcus.
Biometals
; 29(4): 593-609, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27154580
17.
Tackling the problem of HIV drug resistance.
Postepy Biochem
; 62(3): 273-279, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-28132481
18.
Long-Range Electrostatics-Induced Two-Proton Transfer Captured by Neutron Crystallography in an Enzyme Catalytic Site.
Angew Chem Int Ed Engl
; 55(16): 4924-7, 2016 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26958828
19.
Identifying representative drug resistant mutants of HIV.
BMC Bioinformatics
; 16 Suppl 17: S1, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26678327
20.
The combined structural and kinetic characterization of a bacterial nitronate monooxygenase from Pseudomonas aeruginosa PAO1 establishes NMO class I and II.
J Biol Chem
; 289(34): 23764-75, 2014 Aug 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-25002579