Shoeprint retrieval: Core point alignment for pattern comparison.

PURPOSE: Shoeprint recognition has been widely used as forensic evidence in criminal cases. The purpose of this study is to propose a shoeprint retrieval method based on core point alignment for pattern analysis. METHOD: The proposed method firstly detects contour points in a black-and-white shoeprint image. These reliable contour points are selected to simulate the left and right sidelines of the shoeprint by a curve fitting method. Subsequently, the most concave points along the left and right sidelines can determine the core point of the shoeprint, thereby partitioning the shoeprint into circular regions. Next, the Zernike moments of the circular regions are calculated for pattern descriptions of each region. Finally, the Euclidean distance is measured to match the shoeprints with the same pattern. RESULT: The highest APR=0.726 is obtained from the first four Zernike moments with a radius of 90pixels and three baselines. The experimental results also show that the Zernike method in any order always outperforms the compared moment invariant and GLCM method. The experimental results also indicate that the core point is more stable than the gravity center in the both sets, because the standard deviation values of the core point are less than that of the gravity center. CONCLUSIONS: This study has verified that the proposed method can effectively align shoeprints for pattern comparison.

Patterned graphene oxide via one-step thermal annealing for controlling collective cell migration.

Graphene oxide (GO) is a two-dimensional metastable nanomaterial. Interestingly, GO formed oxygen clusterings in addition to oxidized and graphitic phases during the low-temperature thermal annealing process, which could be further used for biomolecule bonding. By harnessing this property of GO, we created a bio-interface with patterned structures with a common laboratory hot plate that could tune cellular behavior by physical contact. Due to the regional distribution of oxygen clustering at the interface, we refer to it as patterned annealed graphene oxide (paGO). In addition, since the paGO was a heterogeneous interface and bonded biomolecules to varying degrees, arginine-glycine-aspartic acid (RGD) was modified on it and successfully regulated cellular-directed growth and migration. Finally, we investigated the FRET phenomenon of this heterogeneous interface and found that it has potential as a biosensor. The paGO interface has the advantages of easy regulation and fabrication, and the one-step thermal reduction method is suitable for biological applications. We believe that this low-temperature thermal annealing method would make GO interfaces more accessible, especially for the development of nano-interfacial modifications for biological applications, revealing its potential for biomedical applications.

Mammogram retrieval through machine learning within BI-RADS standards.

A content-based mammogram retrieval system can support usual comparisons made on images by physicians, answering similarity queries over images stored in the database. The importance of searching for similar mammograms lies in the fact that physicians usually try to recall similar cases by seeking images that are pathologically similar to a given image. This paper presents a content-based mammogram retrieval system, which employs a query example to search for similar mammograms in the database. In this system the mammographic lesions are interpreted based on their medical characteristics specified in the Breast Imaging Reporting and Data System (BI-RADS) standards. A hierarchical similarity measurement scheme based on a distance weighting function is proposed to model user's perception and maximizes the effectiveness of each feature in a mammographic descriptor. A machine learning approach based on support vector machines and user's relevance feedback is also proposed to analyze the user's information need in order to retrieve target images more accurately. Experimental results demonstrate that the proposed machine learning approach with Radial Basis Function (RBF) kernel function achieves the best performance among all tested ones. Furthermore, the results also show that the proposed learning approach can improve retrieval performance when applied to retrieve mammograms with similar mass and calcification lesions, respectively.

Identifying prognostic factors for drug rash with eosinophilia and systemic symptoms (DRESS).

Drug rash with eosinophilia and systemic symptoms (DRESS) is a severe cutaneous drug reaction. Although the severity-of-illness score (SCORTEN) has been proposed for toxic epidermal necrolysis (TEN) for 10 years, a prognostic score for DRESS is still lacking. To identify prognostic factors of DRESS patients during hospitalization in one medical health system in Taiwan. We retrospectively reviewed all patients with DRESS diagnosed by dermatologists in Chang Gung Memorial Hospital (CMGH) Health System from 2001 to 2010. To study prognostic factors, we collected data at early disease and maximal disease stages. 91 individuals, including 13 dead patients, were evaluated. Five independent prognostic factors of death were found: heart rate > 90/min, white blood cells >12,000/mm(3) and respiratory rate >20/min (at early disease stage), coagulopathy and gastrointestinal bleeding (at maximal disease stage). In addition, systemic inflammatory response syndrome (SIRS) occurred at a much higher percentage among non-survivors throughout hospitalization. We found tachycardia, leukocytosis, tachypnea, coagulopathy, gastrointestinal bleeding and SIRS were associated with a poor outcome in DRESS patients. DRESS patients with persistent SIRS during hospitalization were also associated with a higher mortality risk. Early recognition and prompt intervention in these factors may improve outcome.

Sarcoidosis with cutaneous granulomatous vasculitis.

Ulceration of non-caseating granulomas is a rare cutaneous presentation of sarcoidosis. Granulomatous vasculitis is classically associated with Wegener's granulomatosis, lymphomatoid granulomatosis or Churg-Strauss syndrome. It is also commonly noted in pulmonary sarcoidosis, but has seldom been reported in cutaneous sarcoidosis, particularly the ulcerative variant. We present a rare case of sarcoidosis with multiple purpuric leg ulcers showing a granulomatous vasculitis histologically.

Identification and segmentation of obscure pectoral muscle in mediolateral oblique mammograms.

OBJECTIVE: X-ray mammography is a widely used and reliable method for detecting pre-symptomatic breast cancer. One of the difficulties in automatically computerized mammogram analysis is the presence of pectoral muscles in mediolateral oblique mammograms because the pectoral muscle does not belong to the scope of the breast. The objective of this study is to identify the boundary of obscure pectoral muscle in mediolateral oblique mammograms. METHODS: Two tentative boundary curves are individually created to be the potential boundaries. To find the first tentative boundary, this study finds local extrema, prunes weak extrema and then determines an appropriate threshold for identifying the brighter tissue, whose edge is considered the first tentative boundary. The second tentative boundary is found by partitioning the breast into several regions, where each local threshold is tuned based on the local intensity. Subsequently, both of these tentative boundaries are used as the reference to create a refined boundary by Hough transform. Then, the refined boundary is partitioned into quadrilateral regions, in which the edge of this boundary is detected. Finally, these reliable edge points are collected to generate the genuine boundary by curve fitting. RESULTS: The proposed method achieves the least mean square error 4.88 ± 2.47 (mean ± standard deviation) and the least misclassification error rate (MER) with 0.00466 ± 0.00191 in terms of MER. CONCLUSION: The experimental results indicate that this method performs best and stably in boundary identification of the pectoral muscle. ADVANCES IN KNOWLEDGE: The proposed method can identify the boundary from obscure pectoral muscle, which has not been solved by the previous studies.

Reconstruction of Banknote Fragments Based on Keypoint Matching Method.

Banknotes may be shredded by a scrap machine, ripped up by hand, or damaged in accidents. This study proposes an image registration method for reconstruction of multiple sheets of banknotes. The proposed method first constructs different scale spaces to identify keypoints in the underlying banknote fragments. Next, the features of those keypoints are extracted to represent their local patterns around keypoints. Then, similarity is computed to find the keypoint pairs between the fragment and the reference banknote. The banknote fragments can determine the coordinate and amend the orientation. Finally, an assembly strategy is proposed to piece multiple sheets of banknote fragments together. Experimental results show that the proposed method causes, on average, a deviation of 0.12457 ± 0.12810° for each fragment while the SIFT method deviates 1.16893 ± 2.35254° on average. The proposed method not only reconstructs the banknotes but also decreases the computing cost. Furthermore, the proposed method can estimate relatively precisely the orientation of the banknote fragments to assemble.

Identification of breast contour for nipple segmentation in breast magnetic resonance images.

PURPOSE: The purpose of this study is to develop a method to simulate the breast contour and segment the nipple in breast magnetic resonance images. METHODS: This study first identifies the chest wall and removes the chest part from the breast MR images. Subsequently, the cleavage and its motion artifacts are removed, distinguishing the separate breasts, where the edge points are sampled for curve fitting. Next, a region growing method is applied to find the potential nipple region. Finally, the potential nipple region above the simulated curve can be removed in order to retain the original smooth contour. RESULTS: The simulation methods can achieve the least root mean square error (RMSE) for certain cases. The proposed YBnd and (Dmin+Dmax)/2 methods are significant due toP = 0.000. The breast contour curve detected by the two proposed methods is closer than that determined by the edge detection method. The (Dmin+Dmax)/2 method can achieve the lowest RMSE of 1.1029 on average, while the edge detection method results in the highest RMSE of 6.5655. This is only slighter better than the comparison methods, which implies that the performance of these methods depends upon the conditions of the cases themselves. Under this method, the maximal Dice coefficient is 0.881, and the centroid difference is 0.36 pixels. CONCLUSIONS: The contributions of this study are twofold. First, a method was proposed to identify and segment the nipple in breast MR images. Second, a curve-fitting method was used to simulate the breast contour, allowing the breast to retain its original smooth shape.

Plant identification through images: Using feature extraction of key points on leaf contours(1.).

PREMISE OF THE STUDY: Because plant identification demands extensive knowledge and complex terminologies, even professional botanists require significant time in the field for mastery of the subject. As plant leaves are normally regarded as possessing useful characteristics for species identification, leaf recognition through images can be considered an important research issue for plant recognition. • METHODS: This study proposes a feature extraction method for leaf contours, which describes the lines between the centroid and each contour point on an image. A length histogram is created to represent the distribution of distances in the leaf contour. Thereafter, a classifier is applied from a statistical model to calculate the matching score of the template and query leaf. • RESULTS: The experimental results show that the top value achieves 92.7% and the first two values can achieve 97.3%. In the scale invariance test, those 45 correlation coefficients fall between the minimal value of 0.98611 and the maximal value of 0.99992. Like the scale invariance test, the rotation invariance test performed 45 comparison sets. The correlation coefficients range between 0.98071 and 0.99988. • DISCUSSION: This study shows that the extracted features from leaf images are invariant to scale and rotation because those features are close to positive correlation in terms of coefficient correlation. Moreover, the experimental results indicated that the proposed method outperforms two other methods, Zernike moments and curvature scale space.

The use of scale-invariance feature transform approach to recognize and retrieve incomplete shoeprints.

Shoeprints left at the crime scene provide valuable information in criminal investigation due to the distinctive patterns in the sole. Those shoeprints are often incomplete and noisy. In this study, scale-invariance feature transform is proposed and evaluated for recognition and retrieval of partial and noisy shoeprint images. The proposed method first constructs different scale spaces to detect local extrema in the underlying shoeprint images. Those local extrema are considered as useful key points in the image. Next, the features of those key points are extracted to represent their local patterns around key points. Then, the system computes the cross-correlation between the query image and each shoeprint image in the database. Experimental results show that full-size prints and prints from the toe area perform best among all shoeprints. Furthermore, this system also demonstrates its robustness against noise because there is a very slight difference in comparison between original shoeprints and noisy shoeprints.

Detection and construction of chest wall on breast magnetic resonance images.

PURPOSE: The purpose of this study is to propose a method for detection and construction of chest wall for breast magnetic resonance images. METHODS: A volume of breast MR slices are firstly acquired and utilized to detect initial points of chest wall. To calibrate the chest wall curve, the points along the curve is set with reference to its neighboring points. Through the calibration method, a curve of chest wall can be detected from a volume of breast magnetic resonance (MR) slices. Such a curve can be applied for segmentation of breast region in a volume of MR images. RESULTS: The experimental results reveal that the minimal RMSE was measured from the setting two polynomial functions and the points from the vertical position ≤320. If all edge points are used to simulate the curve, two circle functions can reach the minimal RMSE. CONCLUSION: The experimental results verify that chest wall for breast density estimation can be better simulated by two circle functions, which simulate right and left chest walls respectively. Furthermore, such a simulation curve is suggested to utilize partial edge points under the given vertical position.

Mammogram retrieval on similar mass lesions.

Enormous numbers of digital mammograms have been produced in hospitals and breast screening centers. To exploit those valuable resources in aiding diagnoses and research, content-based mammogram retrieval systems are required to effectively access the mammogram databases. This paper presents a content-based mammogram retrieval system, which allows medical professionals to seek mass lesions that are pathologically similar to a given example. In this retrieval system, shape and margin features of mass lesions are extracted to represent the characteristics of mammographic lesions. To compare the similarity between the query example and any lesion within the databases, this study proposes a similarity measure scheme which involves the hierarchical arrangement of mammographic features and a weighting distance measure. This makes similarity measure of the retrieval system consistent with the way radiologists observe mass lesions. This study used the DDSM dataset to evaluate the effectiveness of the extracted shape feature and margin feature, respectively. Experimental results demonstrate that, when Zernike moments are used, round-shape masses are the most discriminative among four types of shape; the circumscribed-margin masses can be effectively discriminated among the four types of margins. Moreover, the result also shows that, when retrieving round-shape and circumscribed margin masses, this retrieval system can achieve the highest precision among all mass lesion types.

Estimation of breast density: an adaptive moment preserving method for segmentation of fibroglandular tissue in breast magnetic resonance images.

PURPOSE: Breast density has been found to be a potential indicator for breast cancer risk. The estimation of breast density can be seen as a segmentation problem on fibroglandular tissues from a breast magnetic resonance image. The classic moment preserving is a thresholding method, which can be applied to determine an appropriate threshold value for fibroglandular tissue segmentation. METHODS: This study proposed an adaptive moment preserving method, which combines the classic moment preserving and a thresholding adjustment method. The breast MR images are firstly performed to extract the fibroglandular tissue from the breast tissue. The next step is to obtain the areas of the fibroglandular tissue and the whole breast tissue. Finally, breast density can be estimated for the given breast. RESULTS: The Friedman test shows that the qualities of segmentation are insignificant with p<0.000 and Friedman chi-squared=1116.12. The Friedman test shows that there would be significant differences in the sum of the ranks of at least one segmentation method. Average ranks indicate that the performance of the four methods is ranked as adaptive moment preserving, fuzzy c-means, moment preserving, and Kapur's method in order. Among the four methods, adaptive moment preserving also achieves the minimum values of MAE and RMSE with 9.2 and 12. CONCLUSION: This study has verified that the proposed adaptive moment preserving can identify and segment the fibroglandular tissues from the 2D breast MR images and estimate the degrees of breast density.