Detalhe da pesquisa
1.
Wild-type GBA1 increases the α-synuclein tetramer-monomer ratio, reduces lipid-rich aggregates, and attenuates motor and cognitive deficits in mice.
Proc Natl Acad Sci U S A
; 118(31)2021 08 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34326260
2.
The Parkinson's disease-associated gene ITPKB protects against α-synuclein aggregation by regulating ER-to-mitochondria calcium release.
Proc Natl Acad Sci U S A
; 118(1)2021 01 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33443159
3.
Neurodegeneration and neuroinflammation are linked, but independent of alpha-synuclein inclusions, in a seeding/spreading mouse model of Parkinson's disease.
Glia
; 70(5): 935-960, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35092321
4.
A Stearoyl-Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α-Synuclein Mice.
Ann Neurol
; 89(1): 74-90, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32996158
5.
Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models.
Neurobiol Dis
; 124: 276-288, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30381260
6.
Randomized phase I clinical trial of anti-α-synuclein antibody BIIB054.
Mov Disord
; 34(8): 1154-1163, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31211448
7.
Dose-dependent reduction of somatic expansions but not Htt aggregates by di-valent siRNA-mediated silencing of MSH3 in HdhQ111 mice.
Sci Rep
; 14(1): 2061, 2024 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-38267530
8.
Dopamine covalently modifies and functionally inactivates parkin.
Nat Med
; 11(11): 1214-21, 2005 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-16227987
9.
Lysophosphatidylcholine acyltransferase 1 promotes pathology and toxicity in two distinct cell-based alpha-synuclein models.
Neurosci Lett
; 772: 136491, 2022 02 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-35108590
10.
Discovery of small-molecule positive allosteric modulators of Parkin E3 ligase.
iScience
; 25(1): 103650, 2022 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35024585
11.
The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking.
J Neurochem
; 117(5): 856-67, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21426348
12.
Parkin selectively alters the intrinsic threshold for mitochondrial cytochrome c release.
Hum Mol Genet
; 18(22): 4317-28, 2009 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19679562
13.
Erratum: LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson's Disease Mouse Model.
Mol Ther Nucleic Acids
; 25: 152-154, 2021 Sep 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34458000
14.
Erratum: LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson's Disease Mouse Model.
Mol Ther Nucleic Acids
; 24: 1051-1053, 2021 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34141459
15.
SCD Inhibition Protects from α-Synuclein-Induced Neurotoxicity But Is Toxic to Early Neuron Cultures.
eNeuro
; 8(4)2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34301719
16.
α-Synuclein antisense oligonucleotides as a disease-modifying therapy for Parkinson's disease.
JCI Insight
; 6(5)2021 03 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33682798
17.
Pink1 Parkinson mutations, the Cdc37/Hsp90 chaperones and Parkin all influence the maturation or subcellular distribution of Pink1.
Hum Mol Genet
; 17(4): 602-16, 2008 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18003639
18.
Mitochondrial Dysfunction in Astrocytes: A Role in Parkinson's Disease?
Front Cell Dev Biol
; 8: 608026, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33537300
19.
Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking.
Biochemistry
; 48(9): 2045-52, 2009 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-19152501
20.
Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides.
Trends Cell Biol
; 13(2): 71-8, 2003 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-12559757