Detalhe da pesquisa
1.
Palmitate-mediated induction of neuropeptide Y expression occurs through intracellular metabolites and not direct exposure to proinflammatory cytokines.
J Neurochem
; 159(3): 574-589, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34482548
2.
ORKAMBI-Mediated Rescue of Mucociliary Clearance in Cystic Fibrosis Primary Respiratory Cultures Is Enhanced by Arginine Uptake, Arginase Inhibition, and Promotion of Nitric Oxide Signaling to the Cystic Fibrosis Transmembrane Conductance Regulator Channel.
Mol Pharmacol
; 96(4): 515-525, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31427400
3.
Delineating the regulation of energy homeostasis using hypothalamic cell models.
Front Neuroendocrinol
; 36: 130-49, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25223866
4.
Activation of the omega-3 fatty acid receptor GPR120 mediates anti-inflammatory actions in immortalized hypothalamic neurons.
J Neuroinflammation
; 11: 60, 2014 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24674717
5.
Conformational defects underlie proteasomal degradation of Dent's disease-causing mutants of ClC-5.
Biochem J
; 452(3): 391-400, 2013 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23566014
6.
ATP induces conformational changes in the carboxyl-terminal region of ClC-5.
J Biol Chem
; 286(8): 6733-41, 2011 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-21173145
7.
Hypothalamic miR-1983 Targets Insulin Receptor ß and the Insulin-mediated miR-1983 Increase Is Blocked by Metformin.
Endocrinology
; 163(1)2022 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34919671
8.
A new platform for high-throughput therapy testing on iPSC-derived lung progenitor cells from cystic fibrosis patients.
Stem Cell Reports
; 16(11): 2825-2837, 2021 11 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34678210
9.
A chemical corrector modifies the channel function of F508del-CFTR.
Mol Pharmacol
; 78(3): 411-8, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20501743
10.
ClC transporters: discoveries and challenges in defining the mechanisms underlying function and regulation of ClC-5.
Pflugers Arch
; 460(2): 543-57, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20049483
11.
A small-molecule modulator interacts directly with deltaPhe508-CFTR to modify its ATPase activity and conformational stability.
Mol Pharmacol
; 75(6): 1430-8, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19339490
12.
Tumour necrosis factor α induces neuroinflammation and insulin resistance in immortalised hypothalamic neurones through independent pathways.
J Neuroendocrinol
; 31(1): e12678, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30582235
13.
The CF Canada-Sick Kids Program in individual CF therapy: A resource for the advancement of personalized medicine in CF.
J Cyst Fibros
; 18(1): 35-43, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29685812
14.
Nucleotides bind to the C-terminus of ClC-5.
Biochem J
; 398(2): 289-94, 2006 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16686597
15.
Phenotypic profiling of CFTR modulators in patient-derived respiratory epithelia.
NPJ Genom Med
; 2: 12, 2017 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-28649446
16.
Orkambi® and amplifier co-therapy improves function from a rare CFTR mutation in gene-edited cells and patient tissue.
EMBO Mol Med
; 9(9): 1224-1243, 2017 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28667089
17.
Nitric Oxide Exerts Basal and Insulin-Dependent Anorexigenic Actions in POMC Hypothalamic Neurons.
Mol Endocrinol
; 30(4): 402-16, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26930171
18.
An essential role for ClC-4 in transferrin receptor function revealed in studies of fibroblasts derived from Clcn4-null mice.
J Cell Sci
; 122(Pt 8): 1229-37, 2009 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19339555