Detalhe da pesquisa
1.
Unraveling the antitrypanosomal mechanism of benznidazole and related 2-nitroimidazoles: From prodrug activation to DNA damage.
Mol Microbiol
; 116(2): 674-689, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34061384
2.
Challenges in Chagas Disease Drug Development.
Molecules
; 25(12)2020 Jun 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32560454
3.
Distinct activation mechanisms trigger the trypanocidal activity of DNA damaging prodrugs.
Mol Microbiol
; 106(2): 207-222, 2017 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-28792090
4.
TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei.
Nucleic Acids Res
; 43(Database issue): D637-44, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25300491
5.
Unravelling the role of SNM1 in the DNA repair system of Trypanosoma brucei.
Mol Microbiol
; 96(4): 827-38, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25689597
6.
Evaluating 5-Nitrothiazoles as Trypanocidal Agents.
Antimicrob Agents Chemother
; 60(2): 1137-40, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26596950
7.
Discovery of potent nitrotriazole-based antitrypanosomal agents: In vitro and in vivo evaluation.
Bioorg Med Chem
; 23(19): 6467-76, 2015 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26344593
8.
An essential type I nitroreductase from Leishmania major can be used to activate leishmanicidal prodrugs.
J Biol Chem
; 288(40): 28466-76, 2013 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-23946481
9.
Evaluating aziridinyl nitrobenzamide compounds as leishmanicidal prodrugs.
Antimicrob Agents Chemother
; 58(1): 370-7, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24165190
10.
Evaluating 5-nitrofurans as trypanocidal agents.
Antimicrob Agents Chemother
; 57(4): 1638-47, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23335745
11.
Benznidazole-resistance in Trypanosoma cruzi is a readily acquired trait that can arise independently in a single population.
J Infect Dis
; 206(2): 220-8, 2012 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22551809
12.
Dissecting the interstrand crosslink DNA repair system of Trypanosoma cruzi.
DNA Repair (Amst)
; 125: 103485, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36989950
13.
Nifurtimox activation by trypanosomal type I nitroreductases generates cytotoxic nitrile metabolites.
J Biol Chem
; 286(15): 13088-95, 2011 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21345801
14.
Targeting the substrate preference of a type I nitroreductase to develop antitrypanosomal quinone-based prodrugs.
Antimicrob Agents Chemother
; 56(11): 5821-30, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22948871
15.
Activation of benznidazole by trypanosomal type I nitroreductases results in glyoxal formation.
Antimicrob Agents Chemother
; 56(1): 115-23, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22037852
16.
Design, synthesis, and evaluation of potential prodrugs of DFMO for reductive activation.
Bioorg Med Chem Lett
; 22(21): 6583-6, 2012 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23031595
17.
Synthesis and antikinetoplastid activity of a series of N,N'-substituted diamines.
Bioorg Med Chem Lett
; 22(4): 1712-5, 2012 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22248858
18.
Substoichiometric levels of Cu2+ ions accelerate the kinetics of fiber formation and promote cell toxicity of amyloid-{beta} from Alzheimer disease.
J Biol Chem
; 285(53): 41533-40, 2010 Dec 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-20974842
19.
Synthesis and structure-activity relationships of nitrobenzyl phosphoramide mustards as nitroreductase-activated prodrugs.
Bioorg Med Chem Lett
; 21(13): 3986-91, 2011 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21620697
20.
Structural insights into the catalytic mechanism of Trypanosoma cruzi GPXI (glutathione peroxidase-like enzyme I).
Biochem J
; 425(3): 513-22, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19886864