Pesquisa | BVS IEC

1.

The cost of competency?

Kao, Yun-Ruei; Will, Britta.

Cell ; 186(4): 685-687, 2023 02 16.

Artigo em Inglês | MEDLINE | ID: mdl-36803600

2.

Chaperone-mediated autophagy sustains haematopoietic stem-cell function.

Dong, Shuxian; Wang, Qian; Kao, Yun-Ruei; Diaz, Antonio; Tasset, Inmaculada; Kaushik, Susmita; Thiruthuvanathan, Victor; Zintiridou, Aliona; Nieves, Edward; Dzieciatkowska, Monika; Reisz, Julie A; Gavathiotis, Evripidis; D'Alessandro, Angelo; Will, Britta; Cuervo, Ana Maria.

Nature ; 591(7848): 117-123, 2021 03.

Artigo em Inglês | MEDLINE | ID: mdl-33442062

3.

Complete miRNA-15/16 loss in mice promotes hematopoietic progenitor expansion and a myeloid-biased hyperproliferative state.

Ng, Anita; Lovat, Francesca; Shih, Andrew J; Ma, Yuhong; Pekarsky, Yuri; DiCaro, Frank; Crichton, Lita; Sharma, Esha; Yan, Xiao Jie; Sun, Daqian; Song, Tengfei; Zou, Yong-Rui; Will, Britta; Croce, Carlo M; Chiorazzi, Nicholas.

Proc Natl Acad Sci U S A ; 120(43): e2308658120, 2023 Oct 24.

Artigo em Inglês | MEDLINE | ID: mdl-37844234

4.

Satb1 regulates the self-renewal of hematopoietic stem cells by promoting quiescence and repressing differentiation commitment.

Will, Britta; Vogler, Thomas O; Bartholdy, Boris; Garrett-Bakelman, Francine; Mayer, Jillian; Barreyro, Laura; Pandolfi, Ashley; Todorova, Tihomira I; Okoye-Okafor, Ujunwa C; Stanley, Robert F; Bhagat, Tushar D; Verma, Amit; Figueroa, Maria E; Melnick, Ari; Roth, Michael; Steidl, Ulrich.

Nat Immunol ; 14(5): 437-45, 2013 May.

Artigo em Inglês | MEDLINE | ID: mdl-23563689

5.

Correction: Proteome-wide analysis of chaperone-mediated autophagy targeting motifs.

Kirchner, Philipp; Bourdenx, Mathieu; Madrigal-Matute, Julio; Tiano, Simoni; Diaz, Antonio; Bartholdy, Boris A; Will, Britta; Cuervo, Ana Maria.

PLoS Biol ; 20(2): e3001550, 2022 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-35120120

6.

Asxl1 loss cooperates with oncogenic Nras in mice to reprogram the immune microenvironment and drive leukemic transformation.

You, Xiaona; Liu, Fabao; Binder, Moritz; Vedder, Alexis; Lasho, Terra; Wen, Zhi; Gao, Xin; Flietner, Evan; Rajagopalan, Adhithi; Zhou, Yun; Finke, Christy; Mangaonkar, Abhishek; Liao, Ruiqi; Kong, Guangyao; Ranheim, Erik A; Droin, Nathalie; Hunter, Anthony M; Nikolaev, Sergey; Balasis, Maria; Abdel-Wahab, Omar; Levine, Ross L; Will, Britta; Nadiminti, Kalyan Vara Ganesh; Yang, David; Geissler, Klaus; Solary, Eric; Xu, Wei; Padron, Eric; Patnaik, Mrinal M; Zhang, Jing.

Blood ; 139(7): 1066-1079, 2022 02 17.

Artigo em Inglês | MEDLINE | ID: mdl-34699595

7.

Proteome-wide analysis of chaperone-mediated autophagy targeting motifs.

Kirchner, Philipp; Bourdenx, Mathieu; Madrigal-Matute, Julio; Tiano, Simoni; Diaz, Antonio; Bartholdy, Boris A; Will, Britta; Cuervo, Ana Maria.

PLoS Biol ; 17(5): e3000301, 2019 05.

Artigo em Inglês | MEDLINE | ID: mdl-31150375

8.

LSD1 inhibition exerts its antileukemic effect by recommissioning PU.1- and C/EBPα-dependent enhancers in AML.

Cusan, Monica; Cai, Sheng F; Mohammad, Helai P; Krivtsov, Andrei; Chramiec, Alan; Loizou, Evangelia; Witkin, Matthew D; Smitheman, Kimberly N; Tenen, Daniel G; Ye, Min; Will, Britta; Steidl, Ulrich; Kruger, Ryan G; Levine, Ross L; Rienhoff, Hugh Y; Koche, Richard P; Armstrong, Scott A.

Blood ; 131(15): 1730-1742, 2018 04 12.

Artigo em Inglês | MEDLINE | ID: mdl-29453291

9.

Fighting AML with its own weapons.

Will, Britta.

Blood ; 139(6): 807-809, 2022 02 10.

Artigo em Inglês | MEDLINE | ID: mdl-35142855

10.

Stem and progenitor cell alterations in myelodysplastic syndromes.

Shastri, Aditi; Will, Britta; Steidl, Ulrich; Verma, Amit.

Blood ; 129(12): 1586-1594, 2017 03 23.

Artigo em Inglês | MEDLINE | ID: mdl-28159737

11.

Effects of eltrombopag on mesenchymal stem cells in immune thrombocytopenia purpura.

Will, Britta.

Br J Haematol ; 197(2): 137-138, 2022 04.

Artigo em Inglês | MEDLINE | ID: mdl-35245400

12.

No keto for AML stem cells!

Will, Britta.

Blood ; 136(11): 1219-1221, 2020 09 10.

Artigo em Inglês | MEDLINE | ID: mdl-32957117

13.

IL8-CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells.

Schinke, Carolina; Giricz, Orsolya; Li, Weijuan; Shastri, Aditi; Gordon, Shanisha; Barreyro, Laura; Barreryo, Laura; Bhagat, Tushar; Bhattacharyya, Sanchari; Ramachandra, Nandini; Bartenstein, Matthias; Pellagatti, Andrea; Boultwood, Jacqueline; Wickrema, Amittha; Yu, Yiting; Will, Britta; Wei, Sheng; Steidl, Ulrich; Verma, Amit.

Blood ; 125(20): 3144-52, 2015 May 14.

Artigo em Inglês | MEDLINE | ID: mdl-25810490

14.

New IDH1 mutant inhibitors for treatment of acute myeloid leukemia.

Okoye-Okafor, Ujunwa C; Bartholdy, Boris; Cartier, Jessy; Gao, Enoch N; Pietrak, Beth; Rendina, Alan R; Rominger, Cynthia; Quinn, Chad; Smallwood, Angela; Wiggall, Kenneth J; Reif, Alexander J; Schmidt, Stanley J; Qi, Hongwei; Zhao, Huizhen; Joberty, Gerard; Faelth-Savitski, Maria; Bantscheff, Marcus; Drewes, Gerard; Duraiswami, Chaya; Brady, Pat; Groy, Arthur; Narayanagari, Swathi-Rao; Antony-Debre, Iléana; Mitchell, Kelly; Wang, Heng Rui; Kao, Yun-Ruei; Christopeit, Maximilian; Carvajal, Luis; Barreyro, Laura; Paietta, Elisabeth; Makishima, Hideki; Will, Britta; Concha, Nestor; Adams, Nicholas D; Schwartz, Benjamin; McCabe, Michael T; Maciejewski, Jaroslav; Verma, Amit; Steidl, Ulrich.

Nat Chem Biol ; 11(11): 878-86, 2015 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-26436839

15.

Eltrombopag inhibits the proliferation of leukemia cells via reduction of intracellular iron and induction of differentiation.

Roth, Michael; Will, Britta; Simkin, Guillermo; Narayanagari, Swathi; Barreyro, Laura; Bartholdy, Boris; Tamari, Roni; Mitsiades, Constantine S; Verma, Amit; Steidl, Ulrich.

Blood ; 120(2): 386-94, 2012 Jul 12.

Artigo em Inglês | MEDLINE | ID: mdl-22627766

16.

Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS.

Barreyro, Laura; Will, Britta; Bartholdy, Boris; Zhou, Li; Todorova, Tihomira I; Stanley, Robert F; Ben-Neriah, Susana; Montagna, Cristina; Parekh, Samir; Pellagatti, Andrea; Boultwood, Jacqueline; Paietta, Elisabeth; Ketterling, Rhett P; Cripe, Larry; Fernandez, Hugo F; Greenberg, Peter L; Tallman, Martin S; Steidl, Christian; Mitsiades, Constantine S; Verma, Amit; Steidl, Ulrich.

Blood ; 120(6): 1290-8, 2012 Aug 09.

Artigo em Inglês | MEDLINE | ID: mdl-22723552

17.

Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations.

Will, Britta; Zhou, Li; Vogler, Thomas O; Ben-Neriah, Susanna; Schinke, Carolina; Tamari, Roni; Yu, Yiting; Bhagat, Tushar D; Bhattacharyya, Sanchari; Barreyro, Laura; Heuck, Christoph; Mo, Yonkai; Parekh, Samir; McMahon, Christine; Pellagatti, Andrea; Boultwood, Jacqueline; Montagna, Cristina; Silverman, Lewis; Maciejewski, Jaroslaw; Greally, John M; Ye, B Hilda; List, Alan F; Steidl, Christian; Steidl, Ulrich; Verma, Amit.

Blood ; 120(10): 2076-86, 2012 Sep 06.

Artigo em Inglês | MEDLINE | ID: mdl-22753872

18.

Germline deletion of Igh 3' regulatory region elements hs 5, 6, 7 (hs5-7) affects B cell-specific regulation, rearrangement, and insulation of the Igh locus.

Volpi, Sabrina A; Verma-Gaur, Jiyoti; Hassan, Rabih; Ju, Zhongliang; Roa, Sergio; Chatterjee, Sanjukta; Werling, Uwe; Hou, Harry; Will, Britta; Steidl, Ulrich; Scharff, Matthew; Edelman, Winfried; Feeney, Ann J; Birshtein, Barbara K.

J Immunol ; 188(6): 2556-66, 2012 Mar 15.

Artigo em Inglês | MEDLINE | ID: mdl-22345664

19.

A large gene network in immature erythroid cells is controlled by the myeloid and B cell transcriptional regulator PU.1.

Wontakal, Sandeep N; Guo, Xingyi; Will, Britta; Shi, Minyi; Raha, Debasish; Mahajan, Milind C; Weissman, Sherman; Snyder, Michael; Steidl, Ulrich; Zheng, Deyou; Skoultchi, Arthur I.

PLoS Genet ; 7(6): e1001392, 2011 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-21695229

20.

TMIGD2 is an orchestrator and therapeutic target on human acute myeloid leukemia stem cells.

Wang, Hao; Sica, R Alejandro; Kaur, Gurbakhash; Galbo, Phillip M; Jing, Zhixin; Nishimura, Christopher D; Ren, Xiaoxin; Tanwar, Ankit; Etemad-Gilbertson, Bijan; Will, Britta; Zheng, Deyou; Fooksman, David; Zang, Xingxing.

Nat Commun ; 15(1): 11, 2024 01 02.

Artigo em Inglês | MEDLINE | ID: mdl-38167704

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The cost of competency?

Chaperone-mediated autophagy sustains haematopoietic stem-cell function.

Complete miRNA-15/16 loss in mice promotes hematopoietic progenitor expansion and a myeloid-biased hyperproliferative state.

Satb1 regulates the self-renewal of hematopoietic stem cells by promoting quiescence and repressing differentiation commitment.

Correction: Proteome-wide analysis of chaperone-mediated autophagy targeting motifs.

Asxl1 loss cooperates with oncogenic Nras in mice to reprogram the immune microenvironment and drive leukemic transformation.

Proteome-wide analysis of chaperone-mediated autophagy targeting motifs.

LSD1 inhibition exerts its antileukemic effect by recommissioning PU.1- and C/EBPα-dependent enhancers in AML.

Fighting AML with its own weapons.

Stem and progenitor cell alterations in myelodysplastic syndromes.

Effects of eltrombopag on mesenchymal stem cells in immune thrombocytopenia purpura.

No keto for AML stem cells!

IL8-CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells.

New IDH1 mutant inhibitors for treatment of acute myeloid leukemia.

Eltrombopag inhibits the proliferation of leukemia cells via reduction of intracellular iron and induction of differentiation.

Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS.

Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations.

Germline deletion of Igh 3' regulatory region elements hs 5, 6, 7 (hs5-7) affects B cell-specific regulation, rearrangement, and insulation of the Igh locus.

A large gene network in immature erythroid cells is controlled by the myeloid and B cell transcriptional regulator PU.1.

TMIGD2 is an orchestrator and therapeutic target on human acute myeloid leukemia stem cells.