Detalhe da pesquisa
1.
Novel compounds that synergize with aminoglycoside G418 or eRF3 degraders for translational readthrough of nonsense mutant TP53 and PTEN.
RNA Biol
; 20(1): 368-383, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37339263
2.
Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53.
Genes Dev
; 28(1): 58-70, 2014 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24395247
3.
Correction: WRAP53 Is Essential for Cajal Body Formation and for Targeting the Survival of Motor Neuron Complex to Cajal Bodies.
PLoS Biol
; 16(9): e3000030, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30252836
4.
Genetic landscape of hepatitis B virus-associated diffuse large B-cell lymphoma.
Blood
; 131(24): 2670-2681, 2018 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29545328
5.
Functional characterization of novel germline TP53 variants in Swedish families.
Clin Genet
; 96(3): 216-225, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31081129
6.
Wrap53, a Natural p53 Antisense Transcript Required for p53 Induction upon DNA Damage.
Mol Cell
; 64(5): 1009, 2016 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27912092
7.
Wrap53, a natural p53 antisense transcript required for p53 induction upon DNA damage.
Mol Cell
; 33(4): 462-71, 2009 Feb 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-19250907
8.
Impaired epithelial differentiation of induced pluripotent stem cells from ectodermal dysplasia-related patients is rescued by the small compound APR-246/PRIMA-1MET.
Proc Natl Acad Sci U S A
; 110(6): 2152-6, 2013 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-23355677
9.
APR-246/PRIMA-1(MET) rescues epidermal differentiation in skin keratinocytes derived from EEC syndrome patients with p63 mutations.
Proc Natl Acad Sci U S A
; 110(6): 2157-62, 2013 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-23355676
10.
APR-246 potently inhibits tumour growth and overcomes chemoresistance in preclinical models of oesophageal adenocarcinoma.
Gut
; 64(10): 1506-16, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26187504
11.
Shaping genetic alterations in human cancer: the p53 mutation paradigm.
Cancer Cell
; 12(4): 303-12, 2007 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17936556
12.
Therapeutic targeting of TP53 nonsense mutations in cancer.
Ups J Med Sci
; 1292024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38863730
13.
Pharmacological reactivation of p53 in the era of precision anticancer medicine.
Nat Rev Clin Oncol
; 21(2): 106-120, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38102383
14.
Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs.
J Biol Chem
; 292(48): 19607, 2017 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29196570
15.
WRAP53 is essential for Cajal body formation and for targeting the survival of motor neuron complex to Cajal bodies.
PLoS Biol
; 8(11): e1000521, 2010 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-21072240
16.
Pharmacological induction of translational readthrough of nonsense mutations in the retinoblastoma (RB1) gene.
PLoS One
; 18(11): e0292468, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37917619
17.
The p53 target Wig-1 regulates p53 mRNA stability through an AU-rich element.
Proc Natl Acad Sci U S A
; 106(37): 15756-61, 2009 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19805223
18.
Evolutionary history of the p53 family DNA-binding domain: insights from an Alvinella pompejana homolog.
Cell Death Dis
; 13(3): 214, 2022 03 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35256607
19.
Translational readthrough of nonsense mutant TP53 by mRNA incorporation of 5-Fluorouridine.
Cell Death Dis
; 13(11): 997, 2022 11 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-36433934
20.
Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.
Nat Med
; 8(3): 282-8, 2002 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-11875500